Alex Cross, politie-inspecteur en doctor in de psychologie te Washington, verneemt dat zijn nichtje, die rechten studeert in Noord-Carolina, is verdwenen en waarschijnlijk werd ontvoerd. Hij haast zich naar Durham om er aan de zoekacties deel te nemen. Ver buiten zijn gezagsgebied en tot grote wrevel van de plaatselijke speurders, begint hij zijn eigen onderzoek. Dankzij zijn buitengewoon deductievermogen ontdekt hij dat er eigenlijk acht meisjes verdwenen zijn, en dat een van hen net vermoord werd teruggevonden.
| Directing | Gary Fleder | Director |
| Writing | David Klass | Screenplay |
| Production | David Brown | Producer |
| Sound | Mark Isham | Original Music Composer |
| Camera | Aaron Schneider | Director of Photography |
| Writing | James Patterson | Novel |
| Production | Joe Wizan | Producer |
| Production | C.O. Erickson | Executive Producer |
| Editing | Harvey Rosenstock | Editor |
| Editing | William Steinkamp | Editor |
| Production | Deborah Aquila | Casting |
| Production | Jane Shannon-Smith | Casting |
| Art | Nelson Coates | Production Design |
| Art | Joseph Hodges | Art Direction |
| Art | Linda Lee Sutton | Set Decoration |
| Costume & Make-Up | Abigail Murray | Costume Design |
| Costume & Make-Up | Jeffrey Hamilton | Makeup Artist |
| Costume & Make-Up | Michael Hancock | Makeup Artist |
| Costume & Make-Up | Ben Nye Jr. | Makeup Artist |
| Costume & Make-Up | Leonard MacDonald | Special Effects Makeup Artist |
| Sound | Zack Davis | ADR Editor |
| Sound | Kerry Dean Williams | Dialogue Editor |
| Sound | Nicholas R. Allen | Boom Operator |
| Sound | Michael J. Benavente | Sound Editor |
| Sound | Jeff Clark | Sound Editor |
| Sound | David B. Cohn | Sound Editor |
| Sound | Scott Curtis | Foley Editor |
| Sound | Ken Dufva | Foley Artist |
| Sound | John Dunn | Sound Editor |
| Sound | Tammy Fearing | Foley Editor |
| Sound | David Lee Fein | Foley Artist |
| Sound | Darrell Hanzalik | ADR Editor |
| Sound | Robin Harlan | Foley Artist |
| Sound | Spike Allison Hooper | Assistant Sound Editor |
| Sound | Susan Kurtz | Sound Effects Editor |
| Sound | Sarah Monat | Foley Artist |
| Editing | Phil Hetos | Color Timer |
| Editing | Theresa Repola Mohammed | Negative Cutter |
| Directing | Trey Batchelor | Second Assistant Director |
| Crew | Jophery C. Brown | Stunt Double |
| Crew | Jennifer Watson-Johnston | Stunts |
| Directing | Chuck Picerni Jr. | Second Unit Director |
| Crew | Jimmy N. Roberts | Stunts |
| Crew | Erik Rondell | Stunts |
| Crew | Sandy Berumen | Stunt Double |
| Crew | Norman Howell | Stunts |
| Crew | Rick Avery | Stunts |
| Crew | Tony Donno | Stunts |
| Crew | Tabby Hanson | Stunts |
| Crew | Cliff McLaughlin | Stunts |
| Camera | Rick Bota | Second Unit Director of Photography |
| Crew | Gina Aponte | Stand In |
| Directing | Michael Zimbrich | First Assistant Director |
| Crew | Chuck Picerni Jr. | Stunt Coordinator |
| Directing | Rick Bota | Second Unit Director |
| Lighting | Dwight Campbell | Chief Lighting Technician |
| Sound | Peter Afterman | Music Supervisor |
| Production | C.O. Erickson | Unit Production Manager |
| Production | Steve Wizan | Co-Producer |
| Editing | Armen Minasian | Additional Editor |
| Directing | Elizabeth Ludwick-Bax | Script Supervisor |
| Camera | David Boyd | Camera Operator |
| Camera | Terry Pfrang | First Assistant Camera |
| Camera | Harry Zimmerman | Second Assistant Camera |
| Camera | Bill Brummond | Steadicam Operator |
| Sound | Lee Orloff | Sound Mixer |
| Art | Barry Franenberg | Property Master |
| Production | Cindy Hochman | Production Coordinator |
| Camera | Kevin Wadowski | First Company Grip |
| Costume & Make-Up | Deena Adair | Hairstylist |
| Costume & Make-Up | Frances Mathias | Hair Supervisor |
| Directing | Nancy Blewer | Second Second Assistant Director |
