De criminele organisatie THRUSH heeft de H975-bom gestolen en eist $ 350.000.000, binnen 72 uur te betalen door haar voormalige tegenstander: Napoleon Solo. De gebeurtenis dwingt het agentschap U.N.C.L.E. (United Network Command for Law and Enforcement) om de twee agenten van Sectie II, Solo en Illya Kuryakin, die beiden 15 jaar eerder de gelederen verlieten en die sindsdien zijn teruggekeerd naar het burgerleven, opnieuw te activeren: Kuryakin als modeontwerper, Solo als onafhankelijke zakenman...
Nee, helaas is The Return of the Man from U.N.C.L.E.: The Fifteen Years Later Affair nog niet beschikbaar op Netflix in Nederland.
| Writing | Sam Rolfe | Writer |
| Writing | Michael Sloan | Writer |
| Sound | Gerald Fried | Original Music Composer |
| Camera | Fred J. Koenekamp | Director of Photography |
| Art | Herman F. Zimmerman | Art Direction |
| Directing | Ray Austin | Director |
| Editing | George Jay Nicholson | Editor |
| Production | Nigel Watts | Producer |
| Production | Michael Sloan | Executive Producer |
| Production | Susan Arnold | Casting |
| Production | Robin S. Clark | Production Manager |
| Directing | Craig Huston | First Assistant Director |
| Directing | Richard H. Prince | Second Assistant Director |
| Sound | William Randall Jr. | Production Sound Mixer |
| Camera | Edward Morey III | Camera Operator |
| Directing | Lester Hoyle | Script Supervisor |
| Costume & Make-Up | Robert B. Harris | Wardrobe Supervisor |
| Costume & Make-Up | Barbara Seibert Bolticoff | Costume Design |
| Costume & Make-Up | Mike Moschella | Makeup Artist |
| Art | Charles Pierce | Set Decoration |
| Art | Matt Springman | Property Master |
| Crew | Cliff Wenger | Special Effects |
| Editing | Mark Stevens | Assistant Editor |
| Directing | Gary Jensen | Second Unit Director |
| Production | Karlene Gallegly | Location Manager |
| Production | Faye Oshima Belyeu | Production Coordinator |
| Crew | Rick Mercier | Transportation Coordinator |
| Sound | Dale Johnson | Sound Editor |
| Sound | James D. Young | Music Editor |
| Sound | Jim Cook | Sound Re-Recording Mixer |
| Production | Terry Morse Jr. | Production Executive |