De 22-jarige drugsdealer Chris (Emile Hirsch) schakelt huurmoordenaar Joe Cooper (Ma hew McConaughey) in om zijn moeder uit de weg te ruimen. Met de uitkering van haar levensverzekering kan Chris zijn schulden afbetalen. De slechtgemanierde huurmoordenaar wil de klus wel klaren, op voorwaarde dat Chris' zusje Dottie (Juno Temple) als seksueel onderpand dient totdat hij betaald krijgt. Met tegenzin besluit Chris zijn schuld boven het welzijn van zijn zus te stellen en stemt in met het aanbod. Maar wat als hij het geld nooit bij elkaar krijgt
Nee, helaas is Killer Joe nog niet beschikbaar op Netflix in Nederland.
| Writing | Tracy Letts | Screenplay |
| Directing | William Friedkin | Director |
| Production | Denise Chamian | Casting |
| Production | Scott Einbinder | Producer |
| Production | Nicolas Chartier | Producer |
| Costume & Make-Up | Peggy A. Schnitzer | Costume Design |
| Sound | Tyler Bates | Music |
| Camera | Caleb Deschanel | Director of Photography |
| Production | Christopher Woodrow | Executive Producer |
| Production | Ryan Westheimer | Line Producer |
| Production | Laurence Freed | Co-Executive Producer |
| Art | Franco-Giacomo Carbone | Production Design |
| Editing | Darrin Navarro | Editor |
| Production | Zev Foreman | Executive Producer |
| Production | Patrick Newall | Unit Production Manager |
| Production | Molly Conners | Executive Producer |
| Art | Alice Baker | Set Decoration |
| Production | Jenn Lee | Production Supervisor |
| Production | Jamin O'Brien | Co-Executive Producer |
| Production | Eli Selden | Associate Producer |
| Production | Patrick Newall | Co-Producer |
| Sound | Steve Boeddeker | Sound Designer |
| Production | Giancarlo J. Sini | Production Manager |
| Crew | Chuck Picerni Jr. | Stunt Coordinator |
| Directing | George Bott | Second Assistant Director |
| Costume & Make-Up | Marcos Gonzales | Key Hair Stylist |
| Costume & Make-Up | Allison Bauserman | Set Costumer |
| Directing | Michael Salven | First Assistant Director |
| Costume & Make-Up | Krystal Kershaw | Makeup Department Head |
| Directing | Chuck Picerni Jr. | Second Unit Director |
| Costume & Make-Up | Kent Richard | Assistant Hairstylist |
| Costume & Make-Up | Donna Spahn | Assistant Hairstylist |
| Costume & Make-Up | Adrienne Lynn | Assistant Makeup Artist |
| Production | Vicki Cherkas | Executive Producer |
| Crew | O.J. Knighten | Animal Wrangler |
| Crew | Danny Epper | Stunts |
