Na het accepteren van een uitnodiging van een mysterieuze trainer, ontmoeten Ash, Misty en Brock MEWTWO, een kunstmatig gecreëerde Pokémon die wil vechten.
Ja! de film Pokémon: Mewtwo slaat terug evolutie is nu beschikbaar om te kijken op Netflix in Nederland.
| Sound | 宮崎慎二 | Original Music Composer |
| Production | Hidenaga Katakami | Executive Producer |
| Sound | 三間雅文 | Sound Director |
| Production | 岡本順哉 | Executive Producer |
| Directing | Motonori Sakakibara | Director |
| Writing | 田尻智 | Original Concept |
| Writing | 首藤剛志 | Original Story |
| Directing | 湯山邦彦 | Director |
| Writing | 首藤剛志 | Writer |
| Writing | Kunihiko Yuyama | Writer |
| Visual Effects | Pralhad Shivane | Animation |
| Visual Effects | Lee En-ryu | Animation |
| Visual Effects | Amit Raut | Animation |
| Visual Effects | Kuhan Kumar | Animation |
| Visual Effects | Christophe Sayaveth | Animation |
| Visual Effects | Christopher Lazzarotto | Animation |
| Visual Effects | Sameer Hirlekar | Animation |
| Visual Effects | Sivakumar Krishnamoorthy | Animation |
| Visual Effects | Chutinart Warunyuwong | Animation |
| Visual Effects | Rashid Akhtar | Animation |
| Visual Effects | Jeffry Syahputra | Animation |
