In Venice Beach komt naïeveling JB samen met KG en ze vormen de rockband Tenacious D. Omdat ze de beste rockband aller tijden willen worden en dat niet zo gemakkelijk gaat, stelen ze wat ze denken dat hen kan helpen in hun tocht naar het sterrendom: een magisch plectrum van een rock-and-roll museum 300 mijlen verder.
Nee, helaas is Tenacious D in The Pick of Destiny nog niet beschikbaar op Netflix in Nederland.
| Production | Kyle Gass | Producer |
| Production | Stuart Cornfeld | Producer |
| Production | Jack Black | Producer |
| Editing | David Rennie | Editor |
| Writing | Jack Black | Writer |
| Camera | Robert Brinkmann | Director of Photography |
| Art | Maria Baker | Art Direction |
| Writing | Kyle Gass | Writer |
| Writing | Liam Lynch | Writer |
| Art | Martin Whist | Production Design |
| Costume & Make-Up | Dayna Pink | Costume Designer |
| Production | Georgia Kacandes | Executive Producer |
| Crew | Brian Avery | Stunt Coordinator |
| Sound | John King | Original Music Composer |
| Crew | Rick Avery | Stunt Coordinator |
| Production | Jeanne McCarthy | Casting |
| Production | Richard Brener | Executive Producer |
| Production | Cale Boyter | Executive Producer |
| Production | Ben Stiller | Executive Producer |
| Crew | Tad Griffith | Stunt Double |
| Production | Juel Bestrop | Casting |
| Crew | John Ashker | Stunt Double |
| Production | Toby Emmerich | Executive Producer |
| Sound | Andrew Gross | Original Music Composer |
| Directing | Liam Lynch | Director |
| Crew | Cole S. McKay | Stunt Double |
| Crew | Joni Avery | Stunts |
| Crew | Eliza Coleman | Stunts |
| Crew | Doug Coleman | Stunts |
| Crew | Jack Gill | Stunts |
| Directing | Rick Avery | Second Unit Director |
| Crew | Mic Rodgers | Stunts |
| Crew | Tim Trella | Stunts |
| Crew | Larry Rippenkroeger | Stunts |
| Crew | Danny Wynands | Stunts |
| Crew | Roger Richman | Stunts |
| Crew | Frank Torres | Stunts |
| Crew | Scotty Richards | Stunt Coordinator |
| Crew | Buck McDancer | Stunts |
| Crew | Ed McDermott II | Stunt Driver |
| Crew | Angelique Midthunder | Stunt Driver |
| Crew | Ian Quinn | Stunts |
| Crew | Rick Miller | Stunt Double |
| Crew | Terry Jackson | Stunts |
| Crew | Brian Machleit | Stunts |
| Crew | Steve Hart | Stunts |
| Crew | Michael Hugghins | Stunts |
| Crew | Jody Hart | Stunt Driver |
| Crew | Tom Elliott | Stunts |
| Crew | Sean Graham | Stunts |
| Crew | Robert Chapin | Stunts |
| Crew | Mike Avery | Stunts |
| Crew | Kevin Abercrombie | Stunts |
| Crew | Jeff Brockton | Stunts |
| Crew | Dean Bailey | Stunts |
| Visual Effects | David D. Johnson | Visual Effects Supervisor |
| Crew | Lisa Avery | Stunts |
| Visual Effects | Bill Church | Visual Effects |
| Visual Effects | John Coats | Visual Effects |
| Visual Effects | Brent M. Bowen | Visual Effects |
| Sound | David Bach | Supervising Sound Editor |
| Sound | Marc Glassman | Sound Effects Editor |
| Sound | Orada Jusatayanond | Sound Effects Editor |
| Sound | Clayton Weber | Sound Effects Editor |
| Sound | Derek Vanderhorst | Sound Effects Editor |
| Sound | Elmo Weber | Supervising Sound Editor |
| Crew | Andy Weder | Special Effects Coordinator |
| Art | Mike Piccirillo | Art Department Coordinator |
| Directing | Heather Grierson | Second Assistant Director |
| Directing | Milos Milicevic | First Assistant Director |
| Directing | Velvet Andrews-Smith | Second Second Assistant Director |
| Directing | Ivan Kraljević | Second Second Assistant Director |
| Production | Ralph Bertelle | Production Supervisor |
| Production | Erik Holmberg | Executive In Charge Of Production |
| Costume & Make-Up | Kate Shorter | Makeup Department Head |
| Costume & Make-Up | Barney Burman | Makeup Designer |
| Costume & Make-Up | Linda D. Flowers | Hair Department Head |
| Costume & Make-Up | Merribelle Anderson | Key Hair Stylist |
| Costume & Make-Up | Ralis Kahn | Makeup Artist |
| Costume & Make-Up | Toni G | Special Effects Makeup Artist |
| Costume & Make-Up | Michael Marino | Special Effects Makeup Artist |
| Costume & Make-Up | Scott Stoddard | Special Effects Makeup Artist |
| Costume & Make-Up | Justin Stafford | Special Effects Makeup Artist |
| Costume & Make-Up | Mike Smithson | Special Effects Makeup Artist |
| Costume & Make-Up | Yeşim "Shimmy" Osman | Hairstylist |
| Art | Don Diers | Set Decoration |
| Sound | Jack Black | Songs |
| Sound | Kyle Gass | Songs |
| Directing | Pamela Alch | Script Supervisor |
| Costume & Make-Up | Hope Slepak | Costume Supervisor |
| Camera | Jon Myers | Steadicam Operator |
| Camera | Zade Rosenthal | Still Photographer |
| Camera | David B. Nowell | Aerial Director of Photography |
| Camera | Paul Hughen | Second Unit Director of Photography |
| Camera | Michael FitzMaurice | Camera Operator |
| Camera | Thomas Vandermillen | First Assistant Camera |
| Art | David Hartman | Production Illustrator |
