Roberta, de jonge gefrustreerde echtgenote van een verkoper van badkuipen, is helemaal gefascineerd door een oproepje in de krant. 'Wanhopig gezocht: Susan' luidt de tekst, en de afzender is een zekere Jim die een afspraak wil maken in het New Yorkse Battery Park. Roberta besluit naar de afgesproken plek te gaan en daar wordt ze prompt met Susan verwisseld. Zo ontmoet ze Dez, de vriend van Jim, die zeer van haar gecharmeerd is. Maar hij is niet de enige die achter haar aanzit. Er is namelijk ook nog een moordenaar die jacht maakt op een paar oorringen die in het bezit zijn van Susan...
Nee, helaas is Desperately Seeking Susan nog niet beschikbaar op Netflix in Nederland.
| Directing | Susan Seidelman | Director |
| Writing | Leora Barish | Writer |
| Art | Santo Loquasto | Production Design |
| Costume & Make-Up | Werner Sherer | Hairstylist |
| Sound | Danny Goldberg | Music Supervisor |
| Production | Billy Hopkins | Casting |
| Camera | Edward Lachman | Director of Photography |
| Production | Risa Bramon Garcia | Casting |
| Sound | Thomas Newman | Original Music Composer |
| Sound | Maurice Schell | Supervising Sound Editor |
| Camera | Andrew D. Schwartz | Still Photographer |
| Camera | Mitch Dubin | First Assistant Camera |
| Art | George DeTitta Jr. | Set Decoration |
| Costume & Make-Up | Richard Dean | Makeup Artist |
| Production | Michael Peyser | Executive Producer |
| Editing | Andrew Mondshein | Editor |
| Directing | Ira Hurvitz | Script Supervisor |
| Production | Michael Peyser | Unit Production Manager |
| Production | Midge Sanford | Producer |
| Sound | Timothy R. Sexton | Music Supervisor |
| Production | Sarah Pillsbury | Producer |
| Sound | Les Lazarowitz | Sound Mixer |
| Directing | Joel Tuber | First Assistant Director |
| Directing | David Dreyfuss | Second Assistant Director |
| Production | Shelley Houis | Production Office Coordinator |
| Production | Todd M. Thaler | Additional Casting |
| Camera | Francis Kenny | Camera Operator |
| Camera | Debbie Sarjeant | Second Assistant Camera |
| Art | Speed Hopkins | Art Direction |
| Art | Glenn Lloyd | Art Department Coordinator |
| Lighting | Ray Quinlan | Gaffer |
| Lighting | James Fitzpatrick | Gaffer |
| Camera | Tom Prate | Key Grip |
| Art | Leslie Bloom | Property Master |
| Sound | Linda Murphy | Boom Operator |
| Costume & Make-Up | William A. Campbell | Wardrobe Supervisor |
| Costume & Make-Up | Melissa Stanton | Wardrobe Supervisor |
| Sound | Peter Odabashian | Sound Editor |
| Sound | Mark Rathaus | Sound Editor |
| Sound | Lou Graf | Sound Editor |
| Sound | Louis Cerborino | Music Editor |
| Sound | Jay Dranch | ADR Editor |
| Sound | Bruce Kitzmeyer | Foley Editor |
| Sound | Randall Coleman | Assistant Sound Editor |
| Sound | Kenton Jakub | Assistant Sound Editor |
| Sound | Stuart Stanley | Assistant Sound Editor |
| Sound | Brunilda Torres | Assistant Sound Editor |
| Production | Julie Lamm | Post Production Accountant |
| Crew | Rocco Derasmo | Transportation Captain |
