Amy, Dominique, Max and Janet zijn zeer jonge maar vooral zeer sexy D.E.B.S oftewel 'special agents', die 'undercover' werken voor de regering. Regelmatig wordt een beroep gedaan op de meiden om de wereld te verlossen van menige snoodaard. In schooluniformen, trekt het dappere viertal ten strijde. Tijdens één van hun missies gaat het echter mis; Amy wordt gegijzeld door juwelendief Lucy Diamond. Terwijl de andere D.E.B.S. denken dat Amy in gevaar is en zich op een reddingsplan beramen, wordt Amy volslagen verliefd op haar voormalige vijand Lucy. Zal Amy de D.E.B.S vaarwel zeggen om met Lucy de horizon tegemoet te gaan? Of zal ze de liefde van haar leven aan zich voor bij laten gaan vanwege haar roeping om de wereld van slechteriken te ontdoen?
Nee, helaas is D.E.B.S. nog niet beschikbaar op Netflix in Nederland.
| Editing | Angela Robinson | Editor |
| Camera | M. David Mullen | Director of Photography |
| Production | Jasmine Kosovic | Producer |
| Directing | Angela Robinson | Director |
| Writing | Angela Robinson | Screenplay |
| Production | Andrea Sperling | Producer |
| Production | Rick Montgomery | Casting |
| Sound | Messy | Original Music Composer |
| Art | Chris Anthony Miller | Production Design |
| Crew | Tom Waite | Stunts |
| Sound | Steven M. Stern | Original Music Composer |
| Directing | Hillary Schwartz | Second Assistant Director |
| Crew | Terri Cadiente | Stunts |
| Crew | Toby Holguin | Stunts |
| Costume & Make-Up | Marc Boyle | Key Hair Stylist |
| Costume & Make-Up | Angie Wells | Makeup Artist |
| Directing | Sholto J. Roeg | First Assistant Director |
| Crew | Dale Gibson | Stunts |
| Production | Stacy Codikow | Co-Producer |
| Production | Douglas Salkin | Associate Producer |
| Costume & Make-Up | Rosemary Lawrence | Key Makeup Artist |
| Crew | Brad Orrison | Stunts |
| Crew | Jill Stokesberry | Stunts |
| Crew | Joel Munoz | Stunts |
| Crew | Boni Yanagisawa | Stunts |
| Production | Pat Scanlon | Co-Producer |
| Crew | Mike Smith | Fight Choreographer |
| Crew | Daniel Arrias | Stunts |
| Lighting | Skip McCraw | Gaffer |
| Crew | Dartenea Bryant | Stunts |
| Crew | Tom Harper | Stunts |
| Production | Larry Kennar | Executive Producer |
| Art | Laura Evans | Set Decoration |
| Crew | Cliff McLaughlin | Stunts |
| Crew | Monica Staggs | Stunts |
| Crew | Nicole Basanda | Stunts |
| Crew | Will Leong | Stunts |
| Crew | Alex Madison | Stunts |
| Crew | Mark Vanselow | Stunts |
| Crew | Ritchie Copenhaver | Stunts |
| Production | Alexandra Kondracke | Associate Producer |
| Directing | Diana Valentine | Script Supervisor |
| Costume & Make-Up | Frank Helmer | Costume Design |
| Crew | Lynn Salvatori | Stunt Coordinator |
| Sound | Howard Paar | Music Supervisor |
| Sound | Wayne Scott Joness | Music Editor |
| Camera | Bruce Birmelin | Still Photographer |
| Sound | Doug Andham | Sound Effects Editor |
| Sound | Jesse Pomeroy | Supervising Sound Editor |
| Sound | Adam Stiles | Sound Effects Editor |
| Sound | Sergio Reyes | Sound Re-Recording Mixer |
| Crew | Torrence Hall | Special Effects |
| Sound | Steve Tushar | Sound Designer |
| Crew | Mike Tristano | Special Effects |
| Camera | Michael Gfelner | Camera Operator |
| Crew | Mike Tristano | Armorer |
| Visual Effects | David Tecson | Visual Effects Supervisor |
| Visual Effects | Mark Thompson | Visual Effects Supervisor |
| Production | Mike Crawford | Line Producer |
| Production | Mike Crawford | Unit Production Manager |
| Camera | Theo Pingarelli | First Assistant Camera |
| Camera | Steve Whitcomb | Second Assistant Camera |
| Art | Greg Runnels | Set Dresser |
| Art | Mark Runnels | Set Dresser |
| Art | Morgan Blackledge | Set Dresser |
