In dit vervolg creëert de boze tovenaar Gargamel een paar ondeugende Smurf-achtige wezens, waarmee hij de magische krachten van de Smurfen hoopt te kunnen benutten. Maar als hij er achter komt dat alleen een echte Smurf hem kan geven wat hij wil en alleen een geheime spreuk die Smurfin weet de wezens kan veranderen in echte smurfen, kidnapt Gargamel Smurfin.
| Production | Randi Wells | Casting |
| Crew | G.A. Aguilar | Stunt Coordinator |
| Editing | Jered Zalman | Assistant Editor |
| Sound | Becky G | Songs |
| Sound | Austin Mahone | Songs |
| Directing | Sean Dwyer | First Assistant Director |
| Visual Effects | Michael Parks | Animation |
| Visual Effects | Juan Miguel Vadell | Animation |
| Crew | Wayne Jaworskyj | Compositors |
| Crew | Jacob Jared Jones | Compositors |
| Crew | Jessica Wolff | Compositors |
| Visual Effects | Dixie Pizani | Animation |
| Crew | David Settlow | Visual Effects Design Consultant |
| Visual Effects | Aaron Williams | VFX Artist |
| Crew | Elizabeth McClurg | Compositors |
| Crew | Joo-Hwan Park | Compositors |
| Visual Effects | Matt Salkin | Visual Effects Coordinator |
| Writing | J. David Stem | Screenplay |
| Directing | Sinan Saber | Third Assistant Director |
| Writing | Peyo | Comic Book |
| Sound | Heitor Pereira | Original Music Composer |
| Costume & Make-Up | Todd Tucker | Makeup Department Head |
| Writing | David N. Weiss | Screenplay |
| Writing | Jay Scherick | Screenplay |
| Writing | David Ronn | Screenplay |
| Writing | Karey Kirkpatrick | Screenplay |
| Writing | J. David Stem | Story |
| Writing | David N. Weiss | Story |
| Writing | Jay Scherick | Story |
| Writing | David Ronn | Story |
| Writing | Peyo | Characters |
| Production | Benita Allen | Co-Producer |
| Production | Raphaël Benoliel | Co-Producer |
| Production | Hendrik Coysman | Co-Producer |
| Production | Véronique Culliford | Co-Producer |
| Production | Ben Haber | Executive Producer |
| Production | Jordan Kerner | Producer |
| Production | Paul Neesan | Executive Producer |
| Production | Maricel Pagulayan | Associate Producer |
| Production | Sabrina Plisco | Associate Producer |
| Production | Ezra Swerdlow | Executive Producer |
| Camera | Phil Meheux | Director of Photography |
| Editing | Sabrina Plisco | Editor |
| Production | Andrea Kenyon | Casting |
| Production | Juliette Ménager | Casting |
| Production | David Rubin | Casting |
| Art | Bill Boes | Production Design |
| Art | David Gaucher | Art Direction |
| Art | Vincent Gingras-Liberali | Art Direction |
| Art | Emma Pucci | Art Direction |
| Art | Michele Laliberte | Supervising Art Director |
| Art | Frédérique Bolté | Set Decoration |
| Art | Pascale Deschênes | Set Decoration |
| Art | Marie-Soleil Dénommé | Set Decoration |
| Costume & Make-Up | Geoffroy Gosselin | On Set Dresser |
| Art | David Laramy | Set Decoration |
| Art | Benoît Tetelin | Set Decoration |
| Costume & Make-Up | Véronique Marchessault | Costume Design |
| Costume & Make-Up | Rita Ryack | Costume Design |
| Production | Paul Boutin | Unit Manager |
| Production | Daniel Carbo | Production Manager |
| Crew | David E. Hall | Post Production Supervisor |
| Production | Nancy Honeycutt | Production Supervisor |
| Production | Michael Killoren | Production Manager |
| Production | Lea Lambert | Production Manager |
| Production | Matthieu Rubin | Unit Production Manager |
| Directing | G.A. Aguilar | Second Unit Director |
| Directing | Benita Allen | First Assistant Director |
| Directing | Anaïs Barrat | Crowd Assistant Director |
| Directing | Felix Baudouin | Second Assistant Director |
| Directing | Carole Schmidlin Blanchard | Crowd Assistant Director |
| Directing | Silver Butler | Second Second Assistant Director |
| Directing | Ariane Côté-Chénier | Additional Third Assistant Director |
| Directing | Dominic Gaglione D'Amico | Third Assistant Director |
| Directing | Antoine Desanti | Assistant Director |
| Directing | Martin Doepner | Additional Third Assistant Director |
| Directing | Yannick Fauchier | Second Assistant Director |
| Directing | Gabrielle Hanne | Second Assistant Director |
| Directing | Sarah Heitz de Chabaneix | Additional Third Assistant Director |
| Directing | Yann Le Boucher | Third Assistant Director |
| Directing | Maxence Paris | Crowd Assistant Director |
| Directing | Serena Yang | Second Unit Director |
| Directing | Raja Gosnell | Director |
| Crew | Alain Moussi | Stunts |
| Crew | Theo Bialek | Digital Effects Supervisor |
