De centrale figuur in deze hallucinante film is Fred Madison, een saxofonist wiens huwelijk met Renee Madison bol staat van onuitgesproken spanningen. Die lopen nog hoger op wanneer ze anonieme videocassettes op hun stoep vinden, iets of iemand begluurt het huis en de bewoners.
Nee, helaas is Lost Highway nog niet beschikbaar op Netflix in Nederland.
| Sound | John Ross | Sound Re-Recording Mixer |
| Sound | Ossama Khuluki | Foley |
| Sound | Ellen Heuer | Foley |
| Lighting | Michael LaViolette | Gaffer |
| Sound | Kevin Kubota | Boom Operator |
| Sound | Frank Gaeta | Sound Re-Recording Mixer |
| Camera | Philip Sloan | Grip |
| Camera | Tim Collins | Grip |
| Production | Cynthia Wise | Production Accountant |
| Sound | Marc Vanocur | Music Editor |
| Sound | Catherine Harper | Foley |
| Art | Patricia Norris | Production Design |
| Sound | Benjamin L. Cook | Sound Effects Editor |
| Crew | Philip Bartko | Special Effects |
| Camera | Paul Wilkowsky | Grip |
| Sound | Susumu Tokunow | Sound mixer |
| Sound | Dean Hovey | Sound Effects Editor |
| Crew | Cassandra King | Post Production Assistant |
| Production | Ed Morris | Executive Consultant |
| Crew | Desmond Cannon | Post Production Supervisor |
| Sound | Cormac Funge | Sound Effects Editor |
| Crew | Michael Wilmot | Special Effects |
| Directing | Cori Glazer | Script Supervisor |
| Production | Elaine J. Huzzar | Casting |
| Editing | Mary Sweeney | Editor |
| Camera | Todd Griffith | Grip |
| Sound | David Lynch | Sound Designer |
| Production | Tom Sternberg | Producer |
| Production | Mary Sweeney | Producer |
| Costume & Make-Up | Debbie Zoller | Makeup Artist |
| Lighting | John Willis III | Best Boy Electric |
| Sound | Derek Marcil | Sound Re-Recording Mixer |
| Sound | Derek Marcil | ADR & Dubbing |
| Crew | David A. Poole | Special Effects |
| Production | Johanna Ray | Casting |
| Directing | David Lynch | Director |
| Camera | Suzanne Tenner | Still Photographer |
| Crew | Bart Barber | Special Effects |
| Production | Julie Duvic | Location Manager |
| Sound | Elmo Weber | Sound Effects Editor |
| Sound | Jiří Zobač | Sound Engineer |
| Camera | Peter Deming | Director of Photography |
| Production | Karen R. Sachs | Production Manager |
| Sound | Javier Bennassar | Sound Effects Editor |
| Production | Deepak Nayar | Unit Production Manager |
| Camera | Paul Hughen | Camera Operator |
| Sound | Bill Brown | Sound Effects Editor |
| Production | Sabrina S. Sutherland | Production Supervisor |
| Art | Leslie Morales | Set Decoration |
| Camera | William Roy Eckert | Grip |
| Sound | David Melhase | Sound Effects Editor |
| Sound | Christopher Moriana | Foley |
| Art | Greg Polutonovich | Sculptor |
| Crew | Bruce Paul Barbour | Stunts |
| Production | Deepak Nayar | Producer |
| Sound | Frank Gaeta | Supervising Sound Editor |
| Sound | David Lynch | Sound Re-Recording Mixer |
| Sound | Frederick Howard | Sound Effects Editor |
| Sound | Mary Erstad | Foley |
| Writing | Barry Gifford | Writer |
| Writing | David Lynch | Writer |
| Crew | Chris Howell | Stunt Coordinator |
| Art | Eric DaRe | Property Buyer |
| Crew | Gene Hartline | Stunts |
| Crew | Joey Box | Stunts |
| Crew | Cole S. McKay | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Sound | Angelo Badalamenti | Original Music Composer |
| Sound | David Grant | Dialogue Editor |
| Sound | Susan Shin | Dialogue Editor |
| Sound | Louis Creveling | Dialogue Editor |
| Art | Craig Sherman Hall | Property Master |
| Camera | Scott Andrew Ressler | First Assistant Camera |
| Sound | David Mann | Foley Editor |
| Sound | Laura Laird | Foley Editor |
| Sound | Marilyn Graf | Foley Editor |
| Sound | Paul Longstaffe | Dialogue Editor |
| Sound | Thomas Jones | Supervising Dialogue Editor |
| Sound | Joshua E. Schneider | Foley Editor |
| Sound | Lucy Sustar | Foley Editor |
| Crew | Robert Jauregui | Stunts |
| Crew | Eliza Coleman | Stunts |
| Editing | Hilary Schroeder | Assistant Editor |
| Crew | Gilbert B. Combs | Stunts |
| Directing | Scott Cameron | First Assistant Director |
| Costume & Make-Up | Patricia Miller | Hairstylist |
| Costume & Make-Up | Hayley Cecile | Assistant Makeup Artist |
| Costume & Make-Up | Michael Burnett | Special Effects Makeup Artist |
| Directing | Adam Rosen | Second Second Assistant Director |
| Directing | Simone Farber | Second Assistant Director |
| Costume & Make-Up | Marisa Aboitiz | Set Costumer |
| Costume & Make-Up | Patricia Norris | Costume Design |
| Art | Russell J. Smith | Art Direction |
| Crew | Rick Seaman | Stunts |
