De centrale figuur in deze hallucinante film is Fred Madison, een saxofonist wiens huwelijk met Renee Madison bol staat van onuitgesproken spanningen. Die lopen nog hoger op wanneer ze anonieme videocassettes op hun stoep vinden, iets of iemand begluurt het huis en de bewoners.
Nee, helaas is Lost Highway nog niet beschikbaar op Netflix in Nederland.
| Sound | David Melhase | Sound Effects Editor |
| Crew | Bart Barber | Special Effects |
| Directing | Cori Glazer | Script Supervisor |
| Costume & Make-Up | Debbie Zoller | Makeup Artist |
| Camera | Paul Hughen | Camera Operator |
| Sound | Susumu Tokunow | Sound mixer |
| Sound | John Ross | Sound Re-Recording Mixer |
| Sound | David Lynch | Sound Re-Recording Mixer |
| Sound | Derek Marcil | ADR & Dubbing |
| Crew | Cassandra King | Post Production Assistant |
| Lighting | John Willis III | Best Boy Electric |
| Sound | Frederick Howard | Sound Effects Editor |
| Sound | Ossama Khuluki | Foley |
| Crew | David A. Poole | Special Effects |
| Sound | Jiří Zobač | Sound Engineer |
| Editing | Mary Sweeney | Editor |
| Crew | Bruce Paul Barbour | Stunts |
| Production | Karen R. Sachs | Production Manager |
| Art | Patricia Norris | Production Design |
| Camera | Peter Deming | Director of Photography |
| Crew | Philip Bartko | Special Effects |
| Sound | Kevin Kubota | Boom Operator |
| Sound | Ellen Heuer | Foley |
| Production | Deepak Nayar | Unit Production Manager |
| Lighting | Michael LaViolette | Gaffer |
| Production | Cynthia Wise | Production Accountant |
| Production | Johanna Ray | Casting |
| Sound | Mary Erstad | Foley |
| Art | Leslie Morales | Set Decoration |
| Production | Julie Duvic | Location Manager |
| Art | Greg Polutonovich | Sculptor |
| Directing | David Lynch | Director |
| Production | Sabrina S. Sutherland | Production Supervisor |
| Sound | Frank Gaeta | Supervising Sound Editor |
| Sound | Catherine Harper | Foley |
| Production | Ed Morris | Executive Consultant |
| Camera | Paul Wilkowsky | Grip |
| Crew | Desmond Cannon | Post Production Supervisor |
| Sound | Derek Marcil | Sound Re-Recording Mixer |
| Sound | Benjamin L. Cook | Sound Effects Editor |
| Crew | Michael Wilmot | Special Effects |
| Production | Tom Sternberg | Producer |
| Sound | Bill Brown | Sound Effects Editor |
| Sound | Javier Bennassar | Sound Effects Editor |
| Sound | Christopher Moriana | Foley |
| Camera | Tim Collins | Grip |
| Sound | Marc Vanocur | Music Editor |
| Production | Deepak Nayar | Producer |
| Camera | Philip Sloan | Grip |
| Camera | Todd Griffith | Grip |
| Sound | Cormac Funge | Sound Effects Editor |
| Sound | David Lynch | Sound Designer |
| Sound | Elmo Weber | Sound Effects Editor |
| Production | Elaine J. Huzzar | Casting |
| Production | Mary Sweeney | Producer |
| Camera | Suzanne Tenner | Still Photographer |
| Camera | William Roy Eckert | Grip |
| Sound | Frank Gaeta | Sound Re-Recording Mixer |
| Sound | Dean Hovey | Sound Effects Editor |
| Writing | Barry Gifford | Writer |
| Writing | David Lynch | Writer |
| Sound | Marilyn Graf | Foley Editor |
| Sound | Lucy Sustar | Foley Editor |
| Sound | Paul Longstaffe | Dialogue Editor |
| Sound | Susan Shin | Dialogue Editor |
| Sound | Angelo Badalamenti | Original Music Composer |
| Sound | David Mann | Foley Editor |
| Sound | Laura Laird | Foley Editor |
| Sound | Joshua E. Schneider | Foley Editor |
| Art | Craig Sherman Hall | Property Master |
| Sound | Thomas Jones | Supervising Dialogue Editor |
| Camera | Scott Andrew Ressler | First Assistant Camera |
| Sound | Louis Creveling | Dialogue Editor |
| Sound | David Grant | Dialogue Editor |
| Crew | Robert Jauregui | Stunts |
| Editing | Hilary Schroeder | Assistant Editor |
| Crew | Rick Seaman | Stunts |
| Art | Eric DaRe | Property Buyer |
| Crew | Cole S. McKay | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Crew | Eliza Coleman | Stunts |
| Crew | Gilbert B. Combs | Stunts |
| Directing | Scott Cameron | First Assistant Director |
| Directing | Simone Farber | Second Assistant Director |
| Directing | Adam Rosen | Second Second Assistant Director |
| Costume & Make-Up | Patricia Miller | Hairstylist |
| Costume & Make-Up | Michael Burnett | Special Effects Makeup Artist |
| Costume & Make-Up | Hayley Cecile | Assistant Makeup Artist |
| Art | Russell J. Smith | Art Direction |
| Costume & Make-Up | Patricia Norris | Costume Design |
| Costume & Make-Up | Marisa Aboitiz | Set Costumer |
| Crew | Chris Howell | Stunt Coordinator |
| Crew | Gene Hartline | Stunts |
| Crew | Joey Box | Stunts |
