De film vertelt het verhaal van Blossom, Bubbles en Buttercup, drie jonge meiden die speciale krachten krijgen, superhelden worden en samenwerken om de slechtaardige gemuteerde aap Mojo te stoppen in zijn plan om de wereld te veroveren. Gebaseerd op de populaire gelijknamige televisie-serie.
Nee, helaas is The Powerpuff Girls Movie nog niet beschikbaar op Netflix in Nederland.
| Directing | Craig McCracken | Director |
| Directing | Dave Kupczyk | Layout |
| Production | Collette Sunderman | Casting |
| Production | Donna Castricone | Producer |
| Editing | Rob Desales | Editor |
| Production | Brian A. Miller | Executive Producer |
| Sound | James L. Venable | Original Music Composer |
| Production | Nikki Vanzo | Executive In Charge Of Production |
| Writing | Charlie Bean | Writer |
| Camera | Genndy Tartakovsky | Director of Photography |
| Production | Craig McCracken | Executive Producer |
| Writing | Lauren Faust | Writer |
| Writing | Craig McCracken | Writer |
| Writing | Paul Rudish | Writer |
| Writing | Don Shank | Writer |
| Writing | Charlie Bean | Storyboard |
| Writing | Lauren Faust | Storyboard |
| Writing | Craig McCracken | Storyboard |
| Writing | Paul Rudish | Storyboard |
| Writing | Don Shank | Storyboard |
| Art | Mike Moon | Art Direction |
| Visual Effects | Genndy Tartakovsky | Animation Director |
| Production | Jennifer Pelphrey | Supervising Producer |
| Production | Mike Lazzo | Co-Executive Producer |
| Production | Linda Simensky | Co-Executive Producer |
| Production | Mark Norman | Co-Executive Producer |
| Sound | Joel Valentine | Sound Designer |
| Crew | Craig McCracken | Creator |
| Production | Melissa Lugar | Production Manager |
| Writing | Charlie Bean | Story |
| Writing | Lauren Faust | Story |
| Writing | Craig McCracken | Story |
| Writing | Amy Keating Rogers | Story |
| Writing | Paul Rudish | Story |
| Writing | Don Shank | Story |
| Art | Carey Yost | Storyboard Assistant |
| Art | Dexter Smith | Storyboard Assistant |
| Visual Effects | Carey Yost | Lead Character Designer |
| Visual Effects | Chris Battle | Character Designer |
| Visual Effects | Andy Bialk | Character Designer |
| Visual Effects | Lauren Faust | Character Designer |
| Visual Effects | Shakeh Hagnazarian | Character Designer |
| Visual Effects | Bob Logan | Character Designer |
| Visual Effects | Craig McCracken | Character Designer |
| Visual Effects | Dexter Smith | Character Designer |
| Art | Bruce Berkey | Background Designer |
| Art | Frederick J. Gardner III | Background Designer |
| Art | Paul Stec | Background Designer |
| Art | Justin K. Thompson | Background Designer |
| Art | Keith Weesner | Background Designer |
| Art | Jim Worthy | Background Designer |
| Production | Nancy Gorée | Production Coordinator |
| Production | Kathy Moore | Production Coordinator |
| Crew | Antonio Gonella | Technical Advisor |
| Sound | Jim Hearn | Dialogue Editor |
| Production | Alicia Parkinson | Post Production Coordinator |
| Sound | Eric Freeman | Sound Editor |
| Sound | Tom Syslo | Sound Editor |
| Sound | Daisuke Sawa | Sound Editor |
| Sound | Roy Braverman | Sound Editor |
| Sound | Timothy J. Borquez | Sound Re-Recording Mixer |
| Sound | Eric Freeman | Sound Re-Recording Mixer |
| Sound | Debra Mason | Foley Artist |
| Sound | Jonathan McPherson | Foley Artist |
| Sound | Steve Worley | Foley Recordist |
| Sound | Joe Privitelli | Music Editor |
| Editing | William DeBoer, Jr. | Negative Cutter |
| Editing | Ed Weyer | Color Timer |
| Editing | Ron Sanders | Color Timer |
| Production | Tammy List | Production Coordinator |
