De film vertelt het verhaal van Blossom, Bubbles en Buttercup, drie jonge meiden die speciale krachten krijgen, superhelden worden en samenwerken om de slechtaardige gemuteerde aap Mojo te stoppen in zijn plan om de wereld te veroveren. Gebaseerd op de populaire gelijknamige televisie-serie.
Nee, helaas is The Powerpuff Girls Movie nog niet beschikbaar op Netflix in Nederland.
| Directing | Craig McCracken | Director |
| Directing | Dave Kupczyk | Layout |
| Sound | James L. Venable | Original Music Composer |
| Editing | Rob Desales | Editor |
| Production | Brian A. Miller | Executive Producer |
| Production | Collette Sunderman | Casting |
| Production | Donna Castricone | Producer |
| Production | Nikki Vanzo | Executive In Charge Of Production |
| Art | Mike Moon | Art Direction |
| Writing | Lauren Faust | Storyboard |
| Writing | Craig McCracken | Storyboard |
| Writing | Lauren Faust | Writer |
| Writing | Craig McCracken | Writer |
| Writing | Charlie Bean | Story |
| Writing | Paul Rudish | Writer |
| Writing | Charlie Bean | Storyboard |
| Writing | Don Shank | Writer |
| Visual Effects | Carey Yost | Lead Character Designer |
| Art | Frederick J. Gardner III | Background Designer |
| Production | Mark Norman | Co-Executive Producer |
| Production | Kathy Moore | Production Coordinator |
| Sound | Eric Freeman | Sound Editor |
| Crew | Antonio Gonella | Technical Advisor |
| Sound | Joel Valentine | Sound Designer |
| Production | Mike Lazzo | Co-Executive Producer |
| Art | Carey Yost | Storyboard Assistant |
| Visual Effects | Chris Battle | Character Designer |
| Visual Effects | Dexter Smith | Character Designer |
| Sound | Steve Worley | Foley Recordist |
| Production | Linda Simensky | Co-Executive Producer |
| Art | Dexter Smith | Storyboard Assistant |
| Art | Justin K. Thompson | Background Designer |
| Production | Alicia Parkinson | Post Production Coordinator |
| Sound | Timothy J. Borquez | Sound Re-Recording Mixer |
| Editing | Ed Weyer | Color Timer |
| Writing | Paul Rudish | Storyboard |
| Writing | Don Shank | Storyboard |
| Visual Effects | Genndy Tartakovsky | Animation Director |
| Production | Melissa Lugar | Production Manager |
| Writing | Lauren Faust | Story |
| Writing | Don Shank | Story |
| Visual Effects | Shakeh Hagnazarian | Character Designer |
| Sound | Eric Freeman | Sound Re-Recording Mixer |
| Editing | William DeBoer, Jr. | Negative Cutter |
| Visual Effects | Andy Bialk | Character Designer |
| Crew | Craig McCracken | Creator |
| Visual Effects | Lauren Faust | Character Designer |
| Sound | Daisuke Sawa | Sound Editor |
| Writing | Craig McCracken | Story |
| Art | Keith Weesner | Background Designer |
| Production | Nancy Gorée | Production Coordinator |
| Writing | Paul Rudish | Story |
| Visual Effects | Craig McCracken | Character Designer |
| Art | Paul Stec | Background Designer |
| Sound | Jim Hearn | Dialogue Editor |
| Writing | Amy Keating Rogers | Story |
| Art | Jim Worthy | Background Designer |
| Sound | Jonathan McPherson | Foley Artist |
| Production | Jennifer Pelphrey | Supervising Producer |
| Sound | Debra Mason | Foley Artist |
| Editing | Ron Sanders | Color Timer |
| Visual Effects | Bob Logan | Character Designer |
| Art | Bruce Berkey | Background Designer |
| Sound | Tom Syslo | Sound Editor |
| Sound | Roy Braverman | Sound Editor |
| Sound | Joe Privitelli | Music Editor |
| Production | Tammy List | Production Coordinator |
| Writing | Charlie Bean | Writer |
| Production | Craig McCracken | Executive Producer |
| Camera | Genndy Tartakovsky | Director of Photography |
