Een buitenaardse symbiote van een andere wereld geeft Peter Parker, alias Spider-Man, nieuwe krachten en een zwart pak die hij goed kan gebruiken om enkele nieuwe vijanden mee te bestrijden. Peters leven lijkt geweldig te zijn met zijn nieuwe pak, totdat hij en zijn geliefden merken dat er iets niet klopt in zijn gedrag...
| Production | Francine Maisler | Casting |
| Art | Leslie A. Pope | Set Decoration |
| Production | Laura Ziskin | Producer |
| Art | Neil Spisak | Production Design |
| Production | Grant Curtis | Producer |
| Editing | Bob Murawski | Editor |
| Costume & Make-Up | James Acheson | Costume Design |
| Production | Stan Lee | Executive Producer |
| Writing | Alvin Sargent | Screenplay |
| Camera | Bill Pope | Director of Photography |
| Directing | Sam Raimi | Director |
| Production | Kevin Feige | Executive Producer |
| Production | Avi Arad | Producer |
| Art | J. Michael Riva | Production Design |
| Costume & Make-Up | Katina Le Kerr | Costume Design |
| Production | Joseph M. Caracciolo Jr. | Executive Producer |
| Sound | Christopher Young | Original Music Composer |
| Production | Kathy Driscoll-Mohler | Casting |
| Crew | Earl A. Hibbert | Visual Effects Editor |
| Art | Aric Cheng | Set Designer |
| Production | Neal Naito | Casting Assistant |
| Production | Jeffrey Gafner | Casting Associate |
| Production | Lavelle Brown | Casting Assistant |
| Production | Will F. Moore | Casting Assistant |
| Writing | Ivan Raimi | Screenplay |
| Art | David F. Klassen | Art Direction |
| Art | Theodore Sharps | Set Designer |
| Art | Jeff Markwith | Set Designer |
| Art | Kevin Cross | Set Designer |
| Production | Richard Baratta | Production Manager |
| Art | Andrea Dopaso | Set Designer |
| Art | Ellen Gessert | Location Scout |
| Production | Denis L. Stewart | Unit Production Manager |
| Production | Merry Alderman | Casting Assistant |
| Production | Katie Taylor | Casting Assistant |
| Art | Noelle King | Set Designer |
| Art | Barbara Mesney | Set Designer |
| Art | Patte Strong-Lord | Set Designer |
| Production | Andrew Saxe | Location Manager |
| Production | Greg Outcalt | Production Coordinator |
| Art | Dawn Swiderski | Art Direction |
| Art | Suzan Wexler | Art Direction |
| Art | Heebok Lee | Title Designer |
| Writing | Sam Raimi | Screenplay |
| Production | David J. Grant | Production Supervisor |
| Production | John DeSimone | Production Coordinator |
| Production | Noelle Green | Production Coordinator |
| Production | V.W. Scheich | Production Coordinator |
| Art | Christopher Burian-Mohr | Art Direction |
| Art | Brett Phillips | Set Designer |
| Production | John Fedynich | Location Manager |
| Directing | Trudy Ramirez | Script Supervisor |
| Camera | Merrick Morton | Still Photographer |
| Camera | Merie Weismiller Wallace | Still Photographer |
| Art | Rick Newsome | Storyboard Designer |
| Writing | Steve Ditko | Comic Book |
| Writing | Stan Lee | Comic Book |
| Crew | Brad Martin | Stunts |
| Crew | Brad Martin | Stunt Double |
| Crew | Alexis Teague | Stunt Double |
| Crew | Natascha Hopkins | Stunts |
| Crew | Jimena Ferrante | Stunt Double |
| Crew | Samantha MacIvor | Stunts |
| Crew | Alison Hyatt Simpson | Stunt Double |
| Crew | Chrissy Weathersby Ball | Stunts |
| Crew | Alexis Teague | Stunts |
| Crew | Shawnna Thibodeau | Stunts |
| Crew | Kimberly Shannon Murphy | Stunts |
| Crew | Aaron Vexler | Stunts |
| Crew | Hank Amos | Stunts |
| Visual Effects | Scott Stokdyk | Visual Effects |
| Visual Effects | Peter Nofz | Visual Effects |
| Visual Effects | Spencer Cook | Visual Effects |
| Visual Effects | John Frazier | Visual Effects |
| Sound | Richard C. Franklin | Sound Effects Editor |
| Sound | Chris M. Jacobson | Sound Effects Editor |
| Sound | Paul N.J. Ottosson | Sound Effects Editor |
| Sound | Daniel Pagan | Sound Effects Editor |
| Sound | Jussi Tegelman | Sound Effects Editor |
| Sound | Greg ten Bosch | Sound Effects Editor |
| Sound | Bernard Weiser | Sound Effects Editor |
| Visual Effects | PeiPei Alena Yuan | Visual Effects Supervisor |
| Visual Effects | Sheena Duggal | Visual Effects Supervisor |
| Visual Effects | Ian Hunter | Visual Effects |
| Visual Effects | Josh R. Jaggars | Visual Effects Producer |
| Costume & Make-Up | Vivian Baker | Makeup & Hair |
| Costume & Make-Up | Tina Earnshaw | Makeup & Hair |
| Costume & Make-Up | Craig Lindberg | Makeup & Hair |
| Costume & Make-Up | Jay Wejebe | Makeup & Hair |
| Production | Patrick Tendai Pfupajena | Additional Production Assistant |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Karin Silvestri | Stunt Double |
| Crew | Caroline Vexler | Stunt Double |
| Sound | Daniel Wehr | Orchestrator |
| Crew | Lance Gilbert | Stunts |
| Crew | Dan Bradley | Stunt Coordinator |
| Directing | Dan Bradley | Second Unit Director |
| Crew | Marguerite Pomerhn Derricks | Choreographer |
| Crew | Paul E. Short | Stunts |
| Writing | Sam Raimi | Screenstory |
| Writing | Ivan Raimi | Screenstory |
| Crew | Darrin Prescott | Stunts |
| Crew | Tim Rigby | Stunts |
| Camera | Daniel Moder | Camera Operator |
| Art | David Swayze | Art Direction |
