Frank Detorri heeft maar een hobby: eten. Alles wat eetbaar is en vooral snacks kan hij niet weerstaan. Frank is lui en heeft een hekel aan beweging. Als hij op zijn werk als verzorger in de dierentuin een hardgekookt ei op de grond laat vallen, bedenkt hij zich geen moment. Hij pakt het op, opent zijn mond en eet het vieze ei op. Vanaf dat moment is er paniek in het ongezonde lichaam van Frank. Osmosis Joses, een jonge witte bloedcel en politieagent, probeert de orde te handhaven in Frank City. Samen met de pijnstiller Drix gaat Osmosis de strijd aanbinden tegen het virus Thrax om Frank en de inwoners van Frank City te behoeden voor een fatale afloop.
Nee, helaas is Osmosis Jones nog niet beschikbaar op Netflix in Nederland.
| Editing | Lois Freeman-Fox | Editor |
| Editing | Sam Seig | Editor |
| Production | Bradley Thomas | Producer |
| Directing | Peter Farrelly | Director |
| Writing | Marc Hyman | Screenplay |
| Production | Peter Farrelly | Producer |
| Sound | Randy Edelman | Original Music Composer |
| Production | Bobby Farrelly | Producer |
| Production | Zak Penn | Producer |
| Directing | Bobby Farrelly | Director |
| Camera | Mark Irwin | Director of Photography |
| Editing | Stephen Schaffer | Editor |
| Visual Effects | Steven Burch | Special Effects Supervisor |
| Visual Effects | Adam Beck | Animation |
| Visual Effects | Paul Dutton | Animation |
| Directing | Audrey Stedman | Layout |
| Directing | Karen Hamrock | Layout |
| Writing | Bob Camp | Storyboard |
| Directing | Jennifer Yuan | Layout |
| Writing | Mark Andrews | Storyboard |
| Visual Effects | Ricardo F. Delgado | Visual Development |
| Writing | Steve Fonti | Storyboard |
| Writing | Daan Jippes | Storyboard |
| Visual Effects | Kevin Johnson | Visual Development |
| Crew | John Harajovic | Special Effects |
| Production | Aaron Parry | Associate Producer |
| Visual Effects | Ruben Chavez | Visual Development |
| Production | John Walker | Associate Producer |
| Visual Effects | Hani D. El-Masri | Visual Development |
| Art | Arlan Jay Vetter | Art Direction |
| Art | Katherine C. Concepcion | Art Department Manager |
| Crew | Leon Delaney | Stunt Coordinator |
| Art | Carol Koch | Sculptor |
| Visual Effects | Darek Gogol | Visual Development |
| Crew | John Bermudes | Special Effects |
| Crew | William 'Billy Jack' Jakielaszek | Special Effects Coordinator |
| Production | Marc S. Fischer | Co-Producer |
| Visual Effects | Chris Aguirre | Visual Development |
| Writing | Barry Caldwell | Storyboard |
| Visual Effects | Jeff Etter | Visual Development |
| Visual Effects | Craig R. Maras | Animation |
| Crew | Jeannine Berger | Post Production Supervisor |
| Visual Effects | Eddie Rosas | Animation |
| Directing | Bill Perkins | Layout |
| Visual Effects | Earl A. Hibbert | Visual Effects |
| Visual Effects | Randy Sanchez | Animation |
| Directing | James P. Alles | Layout |
| Visual Effects | John Williamson | Animation |
| Visual Effects | Joe Giampapa | Animation |
| Visual Effects | Sam Chou | Animation |
| Visual Effects | Shane Prigmore | Animation |
| Visual Effects | Fred Cline | Visual Development |
| Crew | Darlie Brewster | Supervising Animator |
| Costume & Make-Up | Pamela Withers | Costume Design |
| Art | Scott Jacobson | Set Decoration |
| Art | Sydney J. Bartholomew Jr. | Production Design |
| Production | Rick Montgomery | Casting |
| Visual Effects | Ian Mah | Visual Effects Supervisor |
| Costume & Make-Up | Brenda McNally | Hair Department Head |
| Costume & Make-Up | Joe Rossi | Makeup Department Head |
| Sound | Ken Ross | Music Supervisor |
| Visual Effects | Stephan Franck | Lead Animator |
| Directing | Hal Olofsson | First Assistant Director |
| Sound | Randy Thom | Sound Designer |
| Production | Dennis Edwards | Producer |
| Directing | Louis Gonzales | Layout |
| Art | Moroni Taylor | Storyboard Artist |
| Crew | Alan J. Hagge | Systems Administrators & Support |
