Tijdens de Middeleeuwen zijn de Lycans de slaven van de aristocratische vampieren. Lucian (Michael Sheen), één van de Lycans, zet de weerwolven op om te strijden tegen Viktor (Bill Nighy), de koning der vampieren. In zijn strijd voor hun vrijheid wordt Lucian vergezeld door zijn geheime geliefde Sonja (Rhona Mitra). Haar aanwezigheid zorgt voor de nodige veranderingen in de plannen van Lucian.
Ja! de film Underworld: Rise of the Lycans is nu beschikbaar om te kijken op Netflix in Nederland.
| Art | Brendan Heffernan | Art Direction |
| Writing | Danny McBride | Screenplay |
| Production | Gary Lucchesi | Producer |
| Costume & Make-Up | Connie Grayson Criswell | Hairstylist |
| Writing | Danny McBride | Characters |
| Production | Len Wiseman | Producer |
| Art | Dan Hennah | Production Design |
| Crew | Jeff Flitton | Makeup Effects |
| Camera | Ross Emery | Director of Photography |
| Writing | Len Wiseman | Characters |
| Costume & Make-Up | Jane Holland | Costume Design |
| Lighting | Sean O'Neill | Gaffer |
| Production | Beth DePatie | Executive Producer |
| Costume & Make-Up | Sian Evans | Costume Supervisor |
| Art | Gary Mackay | Art Direction |
| Lighting | Jamie Couper | Lighting Technician |
| Writing | Kevin Grevioux | Characters |
| Directing | Patrick Tatopoulos | Director |
| Lighting | John Enright | Best Boy Electric |
| Production | Liz Mullane | Casting |
| Crew | Sean Button | Stunts |
| Crew | Hauk Olafsson | Special Effects |
| Visual Effects | Christopher Warren | VFX Director of Photography |
| Visual Effects | Patrick Tatopoulos | Creature Design |
| Sound | Paul Haslinger | Original Music Composer |
| Crew | Tim Rigby | Stunts |
| Writing | Robert Orr | Story |
| Crew | Dwayne Wiley | Stunts |
| Crew | Allan Smith | Stunts |
| Crew | James Waterhouse-Brown | Stunts |
| Crew | Glen Levy | Stunts |
| Crew | Allan Poppleton | Fight Choreographer |
| Directing | Kimble Rendall | Second Unit Director |
| Crew | Thomas Kiwi | Stunts |
| Costume & Make-Up | Deb Watson | Makeup Supervisor |
| Directing | Nick McKinnon | Second Assistant Director |
| Directing | Paul Grinder | First Assistant Director |
| Crew | Mana Hira Davis | Stunts |
| Crew | Shane Rangi | Stunts |
| Production | Kevin Grevioux | Co-Producer |
| Production | Richard S. Wright | Producer |
| Production | Tom Rosenberg | Producer |
| Writing | Dirk Blackman | Screenplay |
| Production | David Kern | Co-Producer |
| Writing | Howard McCain | Screenplay |
| Production | Eric Reid | Executive Producer |
| Production | Skip Williamson | Executive Producer |
| Production | James McQuaide | Executive Producer |
| Production | Henry Winterstern | Executive Producer |
| Editing | Eric Potter | Editor |
| Writing | Len Wiseman | Story |
| Editing | Peter Amundson | Editor |
| Writing | Danny McBride | Story |
| Crew | Dayna Grant | Stunt Double |
| Crew | Dayna Grant | Stunts |
| Crew | Kee Kee Buckley | Thanks |
| Camera | Evan Pardington | Grip |
| Crew | Stuart Thorp | Stunts |
| Visual Effects | Vincent Cirelli | Visual Effects Supervisor |
