Jack Morrison is een ambitieuze brandweerman die van groentje uitgroeit tot doorgewinterde professional. Zijn gevaarlijke en veeleisende baan vergt veel energie en gaat vaak ten koste van zijn vrouw en kinderen. Steun vindt hij bij zijn mentor en commandant Mike Kennedy en bij zijn tweede familie 'De Broeders van de Brandweerkazerne'. Maar als Jack tijdens een zware klus wordt ingesloten door een vlammenzee, wordt hem duidelijk waar het in het leven echt om draait; familie, waardigheid en moed. Terwijl zijn collega's van Ladder 49 alles doen om hem te redden, hangt Jacks leven aan een zijden draadje.
Nee, helaas is Ladder 49 nog niet beschikbaar op Netflix in Nederland.
| Sound | William Ross | Original Music Composer |
| Editing | M. Scott Smith | Editor |
| Production | Marty P. Ewing | Executive Producer |
| Camera | James L. Carter | Director of Photography |
| Directing | Jay Russell | Director |
| Editing | Bud S. Smith | Editor |
| Production | Casey Silver | Producer |
| Production | Armyan Bernstein | Executive Producer |
| Writing | Lewis Colick | Screenplay |
| Production | Chris Salvaterra | Co-Producer |
| Production | Leigh Simons | Line Producer |
| Production | Anson Downes | Associate Producer |
| Production | Manny Chavez | Associate Producer |
| Production | Nancy Foy | Casting |
| Production | Linda Favila | Associate Producer |
| Costume & Make-Up | Renee Ehrlich Kalfus | Costume Design |
| Art | Jane Burka | Art Department Coordinator |
| Art | Mike Raybould | Greensman |
| Camera | Ronald Hersey | Helicopter Camera |
| Art | Tiffany Zappulla | Set Decoration Buyer |
| Editing | Jeff Smithwick | Color Timer |
| Lighting | Newton TerMeer | Gaffer |
| Sound | John Bissell | Music Supervisor |
| Costume & Make-Up | Matt Danon | Key Hair Stylist |
| Crew | David 'Goldy' Goldsmith | Video Assist Operator |
| Lighting | Jay Kemp | Rigging Gaffer |
| Production | Melissa Stanley Cohen | Production Coordinator |
| Art | Caprice Ericson | Location Scout |
| Camera | Vidal Cohen | Grip |
| Crew | Philippe Gallichet | Chef |
| Crew | Michael Luckeroth | Transportation Coordinator |
| Lighting | Chris Henry | Electrician |
| Lighting | Austin Cross | Lighting Technician |
| Production | Kim Everett | Casting Associate |
| Production | Charles Thomas Baxter | Location Manager |
| Production | Nancy Rae Stone | Executive In Charge Of Production |
| Sound | Bunny Andrews | Music Editor |
| Sound | Armin Steiner | Scoring Mixer |
| Sound | Kelly Cabral | Supervising Sound Editor |
| Art | Peter Oktavec | Painter |
| Costume & Make-Up | Lisa Dietrich | Set Costumer |
| Crew | Douglas A. Walk | Transportation Co-Captain |
| Production | Amy Herman | Unit Production Manager |
| Sound | Rickley W. Dumm | Sound Effects Editor |
| Camera | Andy Colvin | Camera Operator |
| Production | Michele Giordano | Production Supervisor |
| Sound | Aynee Osborn | First Assistant Sound Editor |
| Costume & Make-Up | Erik Boring | Set Dressing Artist |
| Crew | Bryan Badman | Carpenter |
| Crew | John A. Amicarella | Post Production Supervisor |
| Crew | Miguel Sánchez | Security |
| Crew | Gerald Titus | Transportation Captain |
| Production | Don Miller | Production Accountant |
| Sound | Thomas O'Neil Younkman | Sound Designer |
| Art | Tony Burrough | Production Design |
| Sound | Paul Timothy Carden | Sound Editor |
| Art | Kevin Constant | Art Direction |
| Art | Ted Lubonovich II | Construction Foreman |
| Costume & Make-Up | Sherri Bramlett | Hairstylist |
| Crew | Larry Fioritto | Special Effects Coordinator |
| Crew | G. A. Aguilar | Stunt Coordinator |
| Sound | Bruce Babcock | Orchestrator |
| Sound | Kirk Francis | Sound Mixer |
| Art | Hugo Santiago | Assistant Art Director |
| Art | Paul D. Kelly | Set Designer |
| Costume & Make-Up | Catharine Fletcher Incaprera | Costume Supervisor |
| Art | Maggie Martin | Set Decoration |
| Crew | Peter Evangelatos | Craft Service |
| Crew | Jessica Needleman | Post Production Assistant |
| Crew | Peter Damien | Propmaker |
| Crew | Peter J. Silbermann | Unit Publicist |
| Costume & Make-Up | David Atherton | Makeup Artist |
| Crew | Scott E. Corly | Driver |
| Crew | Don Austin | Stand In |
| Crew | Roy Farfel | Stunts |
| Art | Gregory Bolton | Art Direction |
| Camera | Ron Phillips | Still Photographer |
| Crew | Gary Duncan | Picture Car Coordinator |
| Crew | Miller Drake | Visual Effects Editor |
| Directing | Deirdre Horgan | Script Supervisor |
| Sound | William L. Kaplan | Boom Operator |
| Visual Effects | Patrick Phillips | Visual Effects |
| Visual Effects | Peter Donen | Visual Effects Supervisor |
| Visual Effects | Collin Fowler | Visual Effects Coordinator |
| Visual Effects | Chris Flynn | Digital Compositors |
| Visual Effects | Darin McCormick-Millett | Visual Effects Producer |
| Sound | Lauren Stephens | Supervising Sound Editor |
| Directing | Vincent Lascoumes | First Assistant Director |
| Art | Arthur Shippee | Property Master |
| Directing | M. James Arnett | Second Unit Director |
| Sound | Bill Meadows | Sound Recordist |
| Sound | Elizabeth Kenton | Dialogue Editor |
| Production | Barbara Harris | ADR Voice Casting |
| Camera | John Hamilton | Camera Loader |
| Costume & Make-Up | Terri Trupp | Assistant Makeup Artist |
| Costume & Make-Up | Mara Majorowicz | Key Costumer |
| Camera | Alan Gitlin | Digital Imaging Technician |
| Production | Jessica Needleman | Location Assistant |
| Production | Taffy Schweickhardt | Payroll Accountant |
| Production | Judith Babcock | Post Production Coordinator |
| Production | Whitney Green | Production Executive |
| Crew | Ric San Nicholas | Pyrotechnician |
| Directing | Julian Brain | Second Second Assistant Director |
| Costume & Make-Up | Gail A. Fitzgibbons | Wardrobe Supervisor |
| Art | Joseph Musso | Storyboard Artist |
| Crew | Bob Colletti | Stunt Double |
| Camera | Jonas Lagunoff | Best Boy Grip |
| Sound | Natalie Baartz | Music Coordinator |
| Production | Gail Rose | First Assistant Accountant |
| Costume & Make-Up | Deb Dalton | Costumer |
| Production | Beth Dubber | Travel Coordinator |
| Editing | David Bernstein | Colorist |
| Crew | Mark Yant | Technical Advisor |
| Production | Sandra Buttimer | Assistant Location Manager |
| Production | Anthea Strangis | Second Assistant Accountant |
| Art | Eric Ladd | Title Designer |
| Costume & Make-Up | Stephanie Karangelen | Costume Coordinator |
| Directing | Christophe Le Chanu | Second Assistant Director |
| Camera | Ed Nessen | Additional Second Assistant Camera |
| Lighting | Gary Kangrga | Key Rigging Grip |
| Camera | Alisa M. Colley | Second Assistant Camera |
| Production | Cassandra Quigel | Casting Assistant |
| Editing | Jason Bretz | Assistant Editor |
| Editing | Mary Beth Smith | Negative Cutter |
| Production | Nikki Taylor Roberts | Art Department Production Assistant |
| Production | Laura Connors | Assistant Accountant |
| Production | Matthew Barrabee | Production Assistant |
| Sound | Gary Coppola | Foley Mixer |
| Sound | Peter Thomas | Location Sound Mixer |
| Crew | Robert L. Girard | Special Effects Technician |
| Directing | Eric Richard Lasko | Additional Second Assistant Director |
| Sound | Doc Kane | ADR Mixer |
| Production | Jennifer Madeloff | Assistant Production Coordinator |
| Sound | Edward M. Steidele | Foley Artist |
| Production | Rob Mitchell | Controller |
| Sound | William Ross | Conductor |
| Art | Michael Davis | Construction Coordinator |
| Crew | John Cenatiempo | Stunts |
| Crew | Jill Brown | Stunts |
| Crew | Peter Epstein | Stunts |
