Nu George zoveel tijd doorbrengt met zijn nieuwe vriend Will, voelt Stuart zich eenzaam. Wanneer hij in zijn rode sportautootje naar huis rijdt, wordt hij opgeschrikt door een uit de lucht vallende vogel. Haar naam is Margalo, ze is gewond aan haar vleugel en ze wordt achtervolgd door een grote valk. Stuart neemt haar mee naar huis. Wanneer Margalo spoorloos verdwijnt, ontdekt Stuart dat ze door de Valk wordt bedreigd en dat hij haar gemene dingen laat doen. Met de hulp van de kat Snowbell, probeert hij Margalo te redden.
Nee, helaas is Stuart Little 2 nog niet beschikbaar op Netflix in Nederland.
| Sound | Alan Silvestri | Original Music Composer |
| Editing | Priscilla Nedd-Friendly | Editor |
| Directing | Rob Minkoff | Director |
| Camera | Steven Poster | Director of Photography |
| Production | Douglas Wick | Producer |
| Visual Effects | Craig R. Maras | Animation |
| Visual Effects | Angie Jones | Animation |
| Art | Thor Freudenthal | Conceptual Design |
| Production | Rob Minkoff | Executive Producer |
| Crew | Tony R. Medina | Propmaker |
| Writing | E.B. White | Characters |
| Writing | Douglas Wick | Story |
| Writing | Bruce Joel Rubin | Story |
| Writing | Bruce Joel Rubin | Screenplay |
| Visual Effects | Jerome Chen | Visual Effects Supervisor |
| Production | Lucy Fisher | Producer |
| Production | Steve Waterman | Executive Producer |
| Production | Jeff Franklin | Executive Producer |
| Production | Jason Clark | Executive Producer |
| Art | Bill Brzeski | Production Design |
| Production | Gail Lyon | Executive Producer |
| Costume & Make-Up | Mona May | Costume Design |
| Production | Francine Maisler | Casting |
| Sound | Bonnie Greenberg | Music Supervisor |
| Crew | Danny Aiello III | Stunt Coordinator |
| Crew | Boone Narr | Stunt Coordinator |
| Production | Michelle Murdocca | Associate Producer |
| Visual Effects | Michelle Murdocca | Visual Effects Producer |
| Visual Effects | Tony Bancroft | Animation Supervisor |
| Visual Effects | Eric Armstrong | Animation Supervisor |
| Art | Shepherd Frankel | Art Direction |
| Production | Rachel Shane | Associate Producer |
| Art | Lisa K. Sessions | Set Decoration |
| Costume & Make-Up | Bonita DeHaven | Makeup Supervisor |
| Costume & Make-Up | Tammy Ashmore | Makeup Artist |
| Costume & Make-Up | Robert Hallowell II | Hair Supervisor |
| Costume & Make-Up | Mary Guerrero | Hairstylist |
| Directing | Mark Vargo | Second Unit Director |
| Crew | Mark Herman | Visual Effects Editor |
| Sound | David A. Whittaker | Supervising Sound Editor |
| Sound | Donald Flick | Sound Designer |
| Sound | Kenneth Karman | Music Editor |
| Crew | Jay Redd | Digital Effects Supervisor |
| Crew | George Denes Suhayda | Visual Effects Art Director |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Visual Effects | Dan Foster | Visual Effects Producer |
| Crew | Christopher Sjoholm | Digital Effects Supervisor |
| Crew | John Cenatiempo | Stunts |
