De berekenende en afstandelijke seriemoordenaar Henry Lee Lucas deelt een appartement met de wat simpele Otis. Wanneer Otis' jongere zus Becky komt logeren, lijkt zij tot Henry's gevoelige kant door te dringen. Maar Otis en Henry gaan ondertussen samen ook steeds vaker op pad, en dat blijft niet zonder gevolgen.
Nee, helaas is Henry: Portrait of a Serial Killer nog niet beschikbaar op Netflix in Nederland.
| Directing | John McNaughton | Director |
| Writing | Richard Fire | Screenplay |
| Writing | John McNaughton | Screenplay |
| Production | Steven A. Jones | Producer |
| Production | John McNaughton | Producer |
| Camera | Charlie Lieberman | Director of Photography |
| Editing | Elena Maganini | Editor |
| Production | Lisa Dedmond | Producer |
| Art | Rick Paul | Art Direction |
| Costume & Make-Up | Patricia Hart | Costume Design |
| Sound | Cory Coken | Sound Editor |
| Production | Malik B. Ali | Executive Producer |
| Production | Waleed B. Ali | Executive Producer |
| Production | Jeffery Lyle Segal | Casting |
| Crew | Michael J. Alonzi | Makeup Effects |
| Costume & Make-Up | Chuck Gatz | Hairstylist |
| Crew | Herb Nordheimer | Makeup Effects |
| Costume & Make-Up | Berndt Rantscheff | Makeup Artist |
| Costume & Make-Up | Jeffery Lyle Segal | Special Effects Makeup Artist |
| Crew | Scott Whitehead | Makeup Effects |
| Production | Lisa Dedmond | Production Manager |
| Crew | Steven A. Jones | Post Production Supervisor |
| Directing | Andrew Bradburn | Second Assistant Director |
| Directing | Paul Chen | First Assistant Director |
| Art | Frank Coronado | Storyboard Artist |
| Art | Rick Paul | Property Master |
| Art | Rick Paul | Set Dresser |
| Sound | Dan Haberkorn | Sound Effects |
| Sound | Jim Moore | Sound Re-Recording Assistant |
| Sound | Steve Wilburn | Sound Re-Recording Assistant |
| Sound | Thomas T. Yore | Sound Recordist |
| Crew | Paul M. Lane | Stunts |
| Camera | Dave Buckley | Grip |
| Camera | Brian Graham | Grip |
| Camera | David Mahlman | Assistant Camera |
| Camera | Paul Petraitis | Still Photographer |
| Camera | Berndt Rantscheff | Still Photographer |
| Camera | Bradley Sellers | Assistant Camera |
| Sound | Steven A. Jones | Music Director |
| Directing | Melanie Hecht | Script Supervisor |
| Art | Steven A. Jones | Title Designer |
| Art | David Le Boy | Title Designer |
| Production | Bradley Magon | Production Assistant |
| Sound | Robert McNaughton | Original Music Composer |
| Sound | Ken Hale | Original Music Composer |
| Sound | Steven A. Jones | Original Music Composer |
