Terwijl ze op een vlucht naar huis zijn vanuit Colombia, wordt het vliegtuig waarin Dr. Carrie Ross en haar dochter zich bevinden, aangevallen door kogelmieren wier steek de meest pijnlijke en dodelijkste ter wereld is. Dr. Ross, een entomoloog, bundelt zijn krachten met luchtmaarschalk Ethan Hart en probeert wanhopig de vlucht van een ramp te redden. Uiteindelijk brengt hun strijd hen dichter bij elkaar en biedt het koppel hoop voor de toekomst.
Nee, helaas is Destination: Infestation nog niet beschikbaar op Netflix in Nederland.
| Production | Kirk Shaw | Producer |
| Art | Joel Fisher | Set Decoration |
| Editing | Joel Snowden | Editor |
| Art | Hitoshi Okamoto | Production Design |
| Camera | Michael Balfry | Director of Photography |
| Writing | Mary Weinstein | Writer |
| Directing | George Mendeluk | Director |
| Camera | Richard Schmon | First Assistant "A" Camera |
| Camera | Ivan Maldonado | "A" Camera Operator |
| Camera | Richard McSeeney | Second Assistant "A" Camera |
| Camera | Kyle Brown | First Assistant "B" Camera |
| Camera | Katie Yu | Still Photographer |
| Camera | Jill MacLauchlan | "B" Camera Operator |
| Art | Tashanna Ducharme | Assistant Art Director |
| Sound | Mark Noda | Sound Mixer |
| Art | Gabriel Spear | Assistant Set Decoration |
| Camera | Ray Wong | Digital Imaging Technician |
| Sound | Simon Bright | Boom Operator |
| Camera | David Walker | Key Grip |
| Costume & Make-Up | Shanna Mair | Assistant Costume Designer |
| Lighting | Jim Swanson | Gaffer |
| Production | Karen Zajac | Location Manager |
| Camera | Tony Derkatsch | Best Boy Grip |
| Camera | Jules Quesnel | Dolly Grip |
| Camera | Sean Jobin | Grip |
| Costume & Make-Up | Elliott Cufaro | On Set Dresser |
| Lighting | Geoff Dane | Best Boy Electric |
| Camera | Angela Liebenberg | Grip |
| Costume & Make-Up | Michael Richen | Dresser |
| Crew | Greg Hartley | Generator Operator |
| Art | Erin Evans | Set Supervisor |
| Costume & Make-Up | Lindsay Borowko | Truck Costumer |
| Production | Scott Outwaite | Location Production Assistant |
| Production | Jamie Tait | Assistant Production Coordinator |
| Crew | Doran Chandler | Legal Services |
| Production | Leah Tanafranca | Payroll Accountant |
| Production | Ken Meisenbacher | Assistant Location Manager |
| Costume & Make-Up | Megan Davies | Assistant Makeup Artist |
| Production | Kasandra Greene | Production Coordinator |
| Costume & Make-Up | Monica Huppert | Key Makeup Artist |
| Production | Sarah Rogers | Unit Manager |
| Directing | Alex Burnett | Third Assistant Director |
| Crew | Tara Fuhre | Craft Service |
| Crew | Randy Caine | Transportation Coordinator |
| Crew | Alvin Ram | Cast Driver |
| Crew | Lilly Workentin | Assistant Chef |
| Production | Edward Rea | Casting Assistant |
| Crew | Todd Masters | Makeup Effects |
| Crew | Michael Zwart | Chef |
| Production | Linda Sims | Post Production Accountant |
| Production | L.A. Hilts | Extras Casting |
| Production | Karen Austin | Production Accountant |
| Production | Bryant Pike | Controller |
| Production | Mai-Britt Kotzman | Payroll Accountant |
| Production | Valentina Carp | Post Production Accountant |
| Production | Dale Bredeson | Location Production Assistant |
| Crew | Chris Labre | Special Effects Assistant |
| Crew | Jim Stewart | Transportation Captain |
| Directing | Tammy Tamkin | Assistant Director Trainee |
| Production | Mike Farias | Key Production Assistant |
| Crew | John McNulty | Special Effects Assistant |
| Crew | Sarah Terry | Legal Services |
| Production | Angela Lamb | Assistant Production Coordinator |
| Crew | Randy Clair | Security Coordinator |
| Crew | Owen Walstrom | Stunt Coordinator |
| Editing | Mark Yuen | First Assistant Editor |
| Visual Effects | Chris Woods | Animation |
| Crew | Charlene Paling | Thanks |
| Sound | Matthew Gionet | Sound Supervisor |
| Editing | Ronald Ramage | Online Editor |
| Visual Effects | Paul Cox | Visual Effects Supervisor |
| Crew | Todd Giroux | Technical Supervisor |
| Visual Effects | Gregg Vallieres | Visual Effects Coordinator |
| Crew | Charlotte Clark | Post Production Supervisor |
| Production | William Higgins | Post Production Coordinator |
| Visual Effects | Jonathan Sibayan | Modeling |
| Crew | Jonathan Dyck | Thanks |
| Sound | Chris Ove | Dialogue Editor |
| Sound | Chester Biolowas | Sound Effects Editor |
| Sound | Mario Loubert | Sound Effects Editor |
| Sound | Peter Allen | Orchestrator |
| Sound | Vince Mai | Orchestrator |
| Visual Effects | David Cheng | Modeling |
| Lighting | Jeremy Sabo | Rigging Supervisor |
| Sound | Derick Cobden | Sound Supervisor |
| Sound | Michael Keeping | Foley Artist |
| Costume & Make-Up | Rebekka Sorensen | Costume Design |
| Production | John Prince | Production Manager |
| Production | Stacey Shaw | Associate Producer |
| Directing | Sara Irvine-Erickson | Second Assistant Director |
| Production | Randy Zalken | Associate Producer |
| Directing | Kevin Speckmaier | First Assistant Director |
| Production | Lindsay MacAdam | Co-Producer |
| Production | Timothy O. Johnson | Executive Producer |
| Production | Barry Perelman | Executive Producer |
| Crew | Allen Benjamin | Special Effects Coordinator |
| Directing | Susan Williams | Script Supervisor |
| Sound | Peter Allen | Original Music Composer |
| Sound | Vincent Mai | Original Music Composer |
