De rechercheurs Martin Riggs, Roger Murtaugh en Lorna Cole zijn terug, samen met de hyperactieve Leo Getz. Het viertal wordt ditmaal bijgestaan door assistent-rechercheur Lee Butters in hun onderzoek naar de mensensmokkel die georganiseerd wordt door een Aziatische misdaadorganisatie. Ze worden al snel geconfronteerd met Wan Sing Ku, de harde man in de organisatie. Dan blijkt al snel dat het oprollen van deze Chinese maffia-bende een zware, dodelijke klus zou kunnen worden voor Riggs en Murtaugh.
Nee, helaas is Lethal Weapon 4 nog niet beschikbaar op Netflix in Nederland.
| Art | J. Michael Riva | Production Design |
| Costume & Make-Up | Ha Nguyen | Costume Design |
| Art | Lauri Gaffin | Set Decoration |
| Art | Richard F. Mays | Art Direction |
| Sound | Michael Kamen | Original Music Composer |
| Camera | Andrzej Bartkowiak | Director of Photography |
| Editing | Frank J. Urioste | Editor |
| Writing | Channing Gibson | Screenplay |
| Sound | Eric Clapton | Original Music Composer |
| Production | Richard Donner | Producer |
| Directing | Richard Donner | Director |
| Editing | Kevin Stitt | Editor |
| Editing | Eric Strand | Editor |
| Art | David F. Klassen | Art Direction |
| Production | Joel Silver | Producer |
| Production | Marion Dougherty | Casting |
| Sound | David Sanborn | Original Music Composer |
| Editing | Dallas Puett | Editor |
| Writing | Shane Black | Characters |
| Crew | Andrew Lipschultz | Unit Publicist |
| Production | R. Anthony Brown | Unit Production Manager |
| Production | Steve Perry | Executive Producer |
| Production | Jim Van Wyck | Executive Producer |
| Writing | Jonathan Lemkin | Story |
| Production | J. Mills Goodloe | Co-Producer |
| Production | Dan Cracchiolo | Co-Producer |
| Writing | Miles Millar | Story |
| Production | Spencer Franklin | Associate Producer |
| Writing | Alfred Gough | Story |
| Production | Ilyse A. Reutlinger | Associate Producer |
| Production | Jennifer Gwartz | Associate Producer |
| Art | Bill 'Kauhane' Hoyt | Standby Painter |
| Art | Walt Hadfield | Construction Coordinator |
| Art | Charisse Cardenas | Set Designer |
| Art | Marc Baird | Production Illustrator |
| Art | Carlo Basail | Greensman |
| Camera | Ray De La Motte | Camera Operator |
| Art | James F. Walker | Construction Foreman |
| Production | Geoff Johns | Co-Producer |
| Art | Wendy Riva | Assistant Art Director |
| Camera | Steve Adcock | Additional Camera |
| Camera | Steven J. Winslow | Camera Technician |
| Costume & Make-Up | Kimberly Guenther Durkin | Costume Supervisor |
| Camera | Andrew Cooper | Still Photographer |
| Costume & Make-Up | Charlene Johnson | Key Hair Stylist |
| Crew | Peter Roderick | Carpenter |
| Crew | Louis Farah | Set Medic |
| Crew | John M. Woodward | Transportation Coordinator |
| Visual Effects | David Taritero | Visual Effects Producer |
| Sound | Mark Kenna | Dolby Consultant |
| Crew | David Fencl | Armorer |
| Crew | Jon G. Belyeu | Special Effects Coordinator |
| Lighting | Tasso Bravos | Best Boy Electric |
| Lighting | Christian J. Killingsworth | Electrician |
| Sound | John Pospisil | Sound Designer |
| Sound | Richard L. Anderson | Sound Effects Editor |
| Camera | Michael J. Coo | Key Grip |
| Crew | Ernest H. Lauterio | Craft Service |
| Crew | Ilyse A. Reutlinger | Post Production Supervisor |
| Lighting | Richard Hartley | Rigging Gaffer |
| Crew | Cory Fleming | Utility Stunts |
| Directing | J. Tom Archuleta | First Assistant Director |
| Sound | Ezra Dweck | Foley Editor |
| Crew | Gil Amaral | Driver |
| Costume & Make-Up | Jeff Hay | Set Dressing Artist |
| Crew | Martin Glover | Video Assist Operator |
| Lighting | Scott Kidner | Lighting Technician |
| Lighting | Robert J. Reilly | Rigging Grip |
| Camera | Hans Bjerno | Aerial Director of Photography |
| Visual Effects | Bill Maher | Visual Effects Coordinator |
| Costume & Make-Up | Kareen Boursier | Hairstylist |
| Crew | Thomas S. Dickson | Projection |
| Editing | Dale E. Grahn | Color Timer |
| Visual Effects | Cristin Pescosolido | Digital Compositors |
| Camera | Bobby Brown | First Assistant Camera |
| Crew | Huan-Chiu Ku | Martial Arts Choreographer |
| Crew | Conrad E. Palmisano | Stunt Coordinator |
| Crew | Bruce Paul Barbour | Stunts |
| Camera | Robert Ikeda | Grip |
| Crew | Laura Gary | Studio Teachers |
| Costume & Make-Up | Charlene Amateau | Set Costumer |
| Production | Thomas A. Davila | Production Accountant |
| Costume & Make-Up | Lisa Deveaux | Makeup Artist |
| Crew | Frank Roughan | Transportation Captain |
| Sound | Baylis Glascock | Assistant Sound Editor |
| Crew | Jerome Butler | Dialect Coach |
| Sound | Todd Bassman | Boom Operator |
| Art | Erik L. Nelson | Property Master |
| Sound | Tim Cooney | Production Sound Mixer |
| Sound | Mark A. Mangini | Supervising Sound Editor |
| Production | Michael Haro | Location Manager |
| Production | Douglas Wright | Casting Associate |
| Sound | Chris Boardman | Orchestrator |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Camera | Bill Brummond | Steadicam Operator |
| Camera | Pete Romano | Underwater Camera |
| Sound | Zigmund Gron | Music Editor |
| Sound | Gregg Rudloff | Sound Re-Recording Mixer |
| Crew | Marcus Miller | Additional Music |
| Sound | Marshall Winn | ADR Editor |
| Sound | James Simcik | Supervising ADR Editor |
| Sound | Susan Dudeck | Dialogue Editor |
| Sound | Avram D. Gold | Supervising Dialogue Editor |
| Sound | William C. Carruth | ADR Editor |
| Directing | Conrad E. Palmisano | Second Unit Director |
| Sound | Stephen McLaughlin | Music Score Producer |
| Production | Geoff Harding | Assistant Location Manager |
| Crew | Richard Castro | Special Effects Assistant |
| Camera | Jacobus Marcus | Camera Loader |
| Lighting | James B. Crawford | Chief Lighting Technician |
| Sound | Troy Porter | ADR Mixer |
| Visual Effects | Dan Levitan | Compositing Supervisor |
| Production | Jason S. Gondek | Accountant |
| Sound | Eric Gotthelf | Foley Mixer |
| Editing | Jonathan Malden | Colorist |
| Lighting | Stanley L. Gonsales | Assistant Chief Lighting Technician |
| Production | Lisa Matsukawa | Production Secretary |
| Crew | Art Fransen | Technical Advisor |
| Editing | Mo Henry | Negative Cutter |
| Camera | Christopher Blauvelt | Second Assistant Camera |
| Crew | Rick Sawaya | Stunt Driver |
| Sound | Michael Kamen | Conductor |
| Camera | Chris Bangma | Assistant Camera |
| Directing | David Ascher | Second Second Assistant Director |
| Art | Christopher Amy | Assistant Property Master |
| Production | Jodie Thomas | Production Assistant |
| Sound | Josephine Nericcio | Assistant Dialogue Editor |
| Sound | Carolyn Tapp | Foley Recordist |
| Crew | Troy Brown | Stunt Double |
| Production | Cynthia Neber | Executive Assistant |
| Crew | Tom von Badinski | Special Effects Technician |
| Camera | Nico Bally | Dolly Grip |
| Sound | Lou Kleinman | Sound Effects Editor |
| Crew | Patricia M. Peters | Stunts |
| Crew | Cheryl Wheeler Duncan | Stunt Double |
| Crew | Erik Cord | Stunts |
| Crew | Troy Gilbert | Stunts |
| Crew | Tim Gilbert | Stunts |
| Crew | Jeff Imada | Stunts |
| Crew | Thomas Rosales Jr. | Stunts |
| Crew | Ronnie Rondell Jr. | Stunts |
| Crew | Jennifer Caputo | Stunts |
| Crew | Annie Ellis | Stunts |
| Crew | Henry Kingi | Stunts |
| Crew | Tony Brubaker | Stunt Double |
| Crew | Lance Gilbert | Stunt Double |
| Crew | Gary McLarty | Stunts |
| Directing | Mic Rodgers | Second Unit Director |
| Crew | Gregory J. Barnett | Stunts |
| Crew | John C. Meier | Stunts |
| Crew | Buddy Joe Hooker | Stunts |
| Crew | Jill Brown | Stunts |
| Crew | Jimmy N. Roberts | Stunts |
| Crew | Billy D. Lucas | Stunts |
| Crew | Danny Epper | Stunts |
| Crew | Mic Rodgers | Stunt Coordinator |
| Crew | Michael Runyard | Stunts |
| Crew | Kenny Endoso | Stunts |
| Crew | Al Goto | Stunts |
| Crew | Tim Trella | Stunts |
| Crew | Michiko Nishiwaki | Stunts |
| Crew | Doc Duhame | Stunts |
| Crew | Tommy J. Huff | Stunts |
| Crew | Lisa Hoyle | Stunts |
| Crew | Henry Kingi Jr. | Stunts |
| Crew | Norman Howell | Stunts |
