De rechercheurs Martin Riggs, Roger Murtaugh en Lorna Cole zijn terug, samen met de hyperactieve Leo Getz. Het viertal wordt ditmaal bijgestaan door assistent-rechercheur Lee Butters in hun onderzoek naar de mensensmokkel die georganiseerd wordt door een Aziatische misdaadorganisatie. Ze worden al snel geconfronteerd met Wan Sing Ku, de harde man in de organisatie. Dan blijkt al snel dat het oprollen van deze Chinese maffia-bende een zware, dodelijke klus zou kunnen worden voor Riggs en Murtaugh.
Nee, helaas is Lethal Weapon 4 nog niet beschikbaar op Netflix in Nederland.
| Sound | Michael Kamen | Original Music Composer |
| Art | J. Michael Riva | Production Design |
| Production | Joel Silver | Producer |
| Sound | David Sanborn | Original Music Composer |
| Sound | Eric Clapton | Original Music Composer |
| Editing | Dallas Puett | Editor |
| Editing | Frank J. Urioste | Editor |
| Art | David F. Klassen | Art Direction |
| Costume & Make-Up | Ha Nguyen | Costume Design |
| Editing | Kevin Stitt | Editor |
| Writing | Channing Gibson | Screenplay |
| Camera | Andrzej Bartkowiak | Director of Photography |
| Production | Marion Dougherty | Casting |
| Directing | Richard Donner | Director |
| Production | Richard Donner | Producer |
| Art | Richard F. Mays | Art Direction |
| Editing | Eric Strand | Editor |
| Art | Lauri Gaffin | Set Decoration |
| Sound | Lou Kleinman | Sound Effects Editor |
| Crew | Billy D. Lucas | Stunts |
| Crew | Danny Epper | Stunts |
| Crew | Mic Rodgers | Stunt Coordinator |
| Crew | Kenny Endoso | Stunts |
| Crew | Michael Runyard | Stunts |
| Production | Jim Van Wyck | Executive Producer |
| Production | Steve Perry | Executive Producer |
| Crew | Al Goto | Stunts |
| Crew | Tim Trella | Stunts |
| Production | Spencer Franklin | Associate Producer |
| Production | J. Mills Goodloe | Co-Producer |
| Writing | Miles Millar | Story |
| Writing | Shane Black | Characters |
| Production | Ilyse A. Reutlinger | Associate Producer |
| Production | Jennifer Gwartz | Associate Producer |
| Writing | Alfred Gough | Story |
| Writing | Jonathan Lemkin | Story |
| Production | Dan Cracchiolo | Co-Producer |
| Crew | Doc Duhame | Stunts |
| Crew | Michiko Nishiwaki | Stunts |
| Crew | Tommy J. Huff | Stunts |
| Crew | Lisa Hoyle | Stunts |
| Crew | Henry Kingi Jr. | Stunts |
| Crew | Patricia M. Peters | Stunts |
| Camera | Hans Bjerno | Aerial Director of Photography |
| Costume & Make-Up | Kimberly Guenther Durkin | Costume Supervisor |
| Crew | Gil Amaral | Driver |
| Camera | Bill Brummond | Steadicam Operator |
| Camera | Andrew Cooper | Still Photographer |
| Costume & Make-Up | Charlene Johnson | Key Hair Stylist |
| Crew | Ernest H. Lauterio | Craft Service |
| Crew | Huan-Chiu Ku | Martial Arts Choreographer |
| Camera | Michael J. Coo | Key Grip |
| Camera | Robert Ikeda | Grip |
| Camera | Pete Romano | Underwater Camera |
| Costume & Make-Up | Lisa Deveaux | Makeup Artist |
| Crew | Jerome Butler | Dialect Coach |
| Camera | Steven J. Winslow | Camera Technician |
| Crew | Peter Roderick | Carpenter |
| Costume & Make-Up | Jeff Hay | Set Dressing Artist |
| Crew | Ilyse A. Reutlinger | Post Production Supervisor |
| Crew | David Fencl | Armorer |
| Costume & Make-Up | Kareen Boursier | Hairstylist |
| Camera | Bobby Brown | First Assistant Camera |
| Costume & Make-Up | Charlene Amateau | Set Costumer |
| Art | Erik L. Nelson | Property Master |
| Crew | Thomas S. Dickson | Projection |
| Lighting | Richard Hartley | Rigging Gaffer |
| Visual Effects | David Taritero | Visual Effects Producer |
| Production | Thomas A. Davila | Production Accountant |
| Sound | Todd Bassman | Boom Operator |
| Sound | Mark Kenna | Dolby Consultant |
| Directing | J. Tom Archuleta | First Assistant Director |
| Sound | Chris Boardman | Orchestrator |
| Editing | Dale E. Grahn | Color Timer |
| Lighting | Christian J. Killingsworth | Electrician |
| Crew | Frank Roughan | Transportation Captain |
| Sound | Ezra Dweck | Foley Editor |
| Sound | Tim Cooney | Production Sound Mixer |
| Sound | John Pospisil | Sound Designer |
| Sound | Mark Mangini | Supervising Sound Editor |
| Lighting | Robert J. Reilly | Rigging Grip |
| Crew | Andrew Lipschultz | Unit Publicist |
| Sound | Baylis Glascock | Assistant Sound Editor |
| Crew | Jon G. Belyeu | Special Effects Coordinator |
| Crew | Martin Glover | Video Assist Operator |
| Lighting | Tasso Bravos | Best Boy Electric |
| Sound | Zigmund Gron | Music Editor |
| Lighting | Scott Kidner | Lighting Technician |
| Crew | Louis Farah | Set Medic |
| Production | R. Anthony Brown | Unit Production Manager |
| Sound | Richard L. Anderson | Sound Effects Editor |
| Visual Effects | Cristin Pescosolido | Digital Compositors |
| Crew | Conrad E. Palmisano | Stunt Coordinator |
| Crew | John M. Woodward | Transportation Coordinator |
| Crew | Cory Fleming | Utility Stunts |
| Production | Douglas Wright | Casting Associate |
| Production | Michael Haro | Location Manager |
| Visual Effects | Bill Maher | Visual Effects Coordinator |
| Crew | Bruce Paul Barbour | Stunts |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Crew | Laura Gary | Studio Teachers |
| Production | Geoff Johns | Co-Producer |
| Art | Wendy Riva | Assistant Art Director |
| Art | Bill 'Kauhane' Hoyt | Standby Painter |
| Art | James F. Walker | Construction Foreman |
| Art | Marc Baird | Production Illustrator |
| Art | Charisse Cardenas | Set Designer |
| Art | Carlo Basail | Greensman |
| Camera | Steve Adcock | Additional Camera |
| Camera | Ray De La Motte | Camera Operator |
| Art | Walt Hadfield | Construction Coordinator |
| Crew | Norman Howell | Stunts |
| Crew | Cheryl Wheeler Duncan | Stunt Double |
| Crew | Erik Cord | Stunts |
| Crew | Troy Gilbert | Stunts |
| Crew | Tim Gilbert | Stunts |
| Crew | Jeff Imada | Stunts |
| Crew | Thomas Rosales Jr. | Stunts |
| Crew | Annie Ellis | Stunts |
| Crew | Jennifer Caputo | Stunts |
| Crew | Ronnie Rondell Jr. | Stunts |
| Sound | Gregg Rudloff | Sound Re-Recording Mixer |
| Crew | Henry Kingi | Stunts |
| Crew | Tony Brubaker | Stunt Double |
| Crew | Marcus Miller | Additional Music |
| Directing | Conrad E. Palmisano | Second Unit Director |
| Sound | Susan Dudeck | Dialogue Editor |
| Sound | Marshall Winn | ADR Editor |
| Sound | William C. Carruth | ADR Editor |
| Sound | Avram D. Gold | Supervising Dialogue Editor |
| Sound | James Simcik | Supervising ADR Editor |
| Crew | Gary McLarty | Stunts |
| Crew | Lance Gilbert | Stunt Double |
| Directing | Mic Rodgers | Second Unit Director |
| Crew | Gregory J. Barnett | Stunts |
| Crew | John C. Meier | Stunts |
| Sound | Stephen McLaughlin | Music Score Producer |
| Crew | Buddy Joe Hooker | Stunts |
| Crew | Jill Brown | Stunts |
| Crew | Jimmy N. Roberts | Stunts |
| Visual Effects | Dan Levitan | Compositing Supervisor |
| Art | Christopher Amy | Assistant Property Master |
| Editing | Mo Henry | Negative Cutter |
| Directing | David Ascher | Second Second Assistant Director |
| Sound | Eric Gotthelf | Foley Mixer |
| Production | Cynthia Neber | Executive Assistant |
| Production | Geoff Harding | Assistant Location Manager |
| Sound | Josephine Nericcio | Assistant Dialogue Editor |
| Lighting | Stanley L. Gonsales | Assistant Chief Lighting Technician |
| Crew | Tom von Badinski | Special Effects Technician |
| Camera | Chris Bangma | Assistant Camera |
| Editing | Jonathan Malden | Colorist |
| Camera | Christopher Blauvelt | Second Assistant Camera |
| Sound | Michael Kamen | Conductor |
| Crew | Art Fransen | Technical Advisor |
| Production | Jodie Thomas | Production Assistant |
| Sound | Troy Porter | ADR Mixer |
| Crew | Troy Brown | Stunt Double |
| Lighting | James B. Crawford | Chief Lighting Technician |
| Sound | Carolyn Tapp | Foley Recordist |
| Camera | Jacobus Marcus | Camera Loader |
| Camera | Nico Bally | Dolly Grip |
| Production | Lisa Matsukawa | Production Secretary |
| Crew | Richard Castro | Special Effects Assistant |
| Crew | Rick Sawaya | Stunt Driver |
| Production | Jason S. Gondek | Accountant |
| Crew | Dick Hancock | Stunts |
| Crew | George Fisher | Stunts |
| Crew | Danny Rogers | Stunts |
| Crew | Tony Snegoff | Stunts |
