Kal Ho Naa Ho vertelt het verhaal van de drie, in New York wonende, vrienden Aman, Rohit en Naina. De essentie van ware vriendschap en het omgaan met geluk en verdriet staan centraal in het verhaal.
| Directing | Nikkhil Advani | Director |
| Writing | Karan Johar | Screenplay |
| Production | Karan Johar | Producer |
| Production | Yash Johar | Producer |
| Camera | Anil Mehta | Director of Photography |
| Editing | Sanjay Sankla | Editor |
| Art | Sharmishta Roy | Production Design |
| Writing | Karan Johar | Story |
| Directing | Ana Cuadra | First Assistant Director |
| Directing | David Coombs | First Assistant Director |
| Directing | Tarun Mansukhani | First Assistant Director |
| Directing | Arjun Kapoor | Assistant Director |
| Directing | Kapil Chopra | Assistant Director |
| Directing | Punit Malhotra | Assistant Director |
| Directing | Shiraz Siddique | Assistant Director |
| Production | Anadil Hossain | Line Producer |
| Production | Ganesh Nankoosingh | Line Producer |
| Production | Hiroo Johar | Associate Producer |
| Production | Alex Schimel | Production Executive |
| Production | Manoj Mittra | Production Executive |
| Production | Driss Benyaklef | Production Manager |
| Production | Gopal Babel | Production Manager |
| Production | Prashant Kunder | Production Manager |
| Crew | Imtiaz Ansari | Production Controller |
| Crew | Rashid Abbasi | Production Controller |
| Writing | Niranjan Iyengar | Dialogue |
| Sound | Ehsaan Noorani | Original Music Composer |
| Sound | Loy Mendonsa | Original Music Composer |
| Sound | Shankar Mahadevan | Original Music Composer |
| Sound | Anuj Mathur | Sound Designer |
| Sound | Ajay Kumar P. B. | Location Sound Recordist |
| Sound | Kuldip Sood | Location Sound Recordist |
| Sound | Ali Merchant | Sound Editor |
| Sound | Kunal Uday Mehta | Sound Editor |
| Sound | Parikshit Lalwani | Sound Editor |
| Sound | Shankar Singh Raghuvanshi | Sound Editor |
| Sound | Vikram Biswas | Foley Artist |
| Sound | Anuj Mathur | Sound Assistant |
| Sound | Prashant Nayar | Sound Re-Recording Mixer |
| Art | Mohammed Kasam Sayyad | Assistant Art Director |
| Production | Rita Powers | Casting Director |
| Production | Sean Powers | Casting Director |
| Crew | Farah Khan | Choreographer |
| Costume & Make-Up | Manish Malhotra | Costume Design |
| Production | Fabio Martinez | Location Manager |
| Production | Joseph White | Location Manager |
| Production | Malaika Johnson | Location Manager |
| Costume & Make-Up | Mickey Contractor | Makeup Artist |
| Visual Effects | Pankaj Khandpur | Visual Effects |
| Directing | Mamta Anand | Assistant Director |
