Cleopatra wil aan Julius Caesar bewijzen dat het volk van Egypte nog altijd het grootste volk ter wereld is. Ze gaat een weddenschap met hem aan om een paleis in Alexandrië te bouwen in drie maanden. De bijna onmogelijke taak dit te verwezenlijken valt te beurt aan Tekenis. Bang om in de maag van een krokodil te verdwijnen roept hij de hulp in van de druïde Panoramix. Samen met Asterix en Obelix gaan ze de strijd aan om het paleis op tijd af te krijgen. Ze worden echter dwars gezeten door Astmagoedis (de rivaal van Tekenis) en door Julius Caesar zelf.
Nee, helaas is Asterix & Obelix: Missie Cleopatra nog niet beschikbaar op Netflix in Nederland.
| Writing | Alain Chabat | Screenplay |
| Directing | Alain Chabat | Director |
| Writing | René Goscinny | Author |
| Production | Claude Berri | Producer |
| Production | Luce Nordmann | Casting |
| Production | Laurent Soulet | Casting |
| Costume & Make-Up | Tanino Liberatore | Costume Design |
| Production | Mustapha Fathi | Casting |
| Art | Laurent Ott | Art Direction |
| Art | Françoise Doré | Set Decoration |
| Production | Noureddine Aberdine | Casting |
| Production | Jeanne Biras | Casting |
| Costume & Make-Up | Florence Sadaune | Costume Design |
| Art | Hoang Thanh At | Production Design |
| Art | Hoang Thanh At | Set Decoration |
| Costume & Make-Up | Sylvie Ferry | Special Effects Makeup Artist |
| Sound | Thierry Lebon | Sound Re-Recording Mixer |
| Costume & Make-Up | Khalid Alami | Key Makeup Artist |
| Costume & Make-Up | Christophe Danchaud | Key Makeup Artist |
| Costume & Make-Up | Turid Follvik | Key Makeup Artist |
| Costume & Make-Up | Muriel Baurens | Key Makeup Artist |
| Costume & Make-Up | Frédéric Lainé | Special Effects Makeup Artist |
| Visual Effects | Thomas Duval | VFX Supervisor |
| Sound | Pierre Excoffier | Sound |
| Production | Dieter Meyer | Associate Producer |
| Sound | Jérôme Lévy | Foley |
| Sound | Olivier Marlangeon | Foley |
| Sound | Jérôme Wiciak | Sound |
| Sound | Mourad Louanchi | Foley Editor |
| Crew | Philippe Guégan | Stunt Coordinator |
| Production | Roland Pellegrino | Associate Producer |
| Production | Thomas Langmann | Associate Producer |
| Sound | Vincent Guillon | Sound |
| Production | Pierre Grunstein | Executive Producer |
| Sound | Gildas Mercier | Sound Editor |
| Visual Effects | Pierre-Alain Bloch | Animation |
| Writing | Albert Uderzo | Author |
| Sound | Philippe Chany | Original Music Composer |
| Production | Alain Chabat | Co-Producer |
| Editing | Stéphane Pereira | Editor |
| Camera | Laurent Dailland | Director of Photography |
| Costume & Make-Up | Philippe Guillotel | Costume Design |
| Directing | Noureddine Aberdine | Assistant Director |
| Directing | Noureddine Douguena | Assistant Director |
| Directing | Stéphane Gluck | First Assistant Director |
| Directing | Larbi Idrissi | Assistant Director |
| Directing | Robert Kechichian | Second Unit Director |
| Directing | Louis Leterrier | Second Assistant Director |
| Directing | Mohamed Nesrate | First Assistant Director |
| Directing | Nicolas Pillard | Assistant Director |
| Directing | Sade Zeriffi | Assistant Director |
| Crew | Jean-Christophe Spadaccini | Special Effects Coordinator |
| Visual Effects | Mélodie Boileau | Visual Effects Coordinator |
| Visual Effects | Thomas Duval | Visual Effects Supervisor |
| Lighting | Mathieu Ullmann | Lighting Artist |
| Visual Effects | Marie Celaya | Animation |
| Visual Effects | Laurent de la Chapelle | Animation |
| Visual Effects | Fabrice Delapierre | Animation |
| Visual Effects | Nicolas Galvani | Animation |
| Visual Effects | Yannick Giaume | Animation |
| Visual Effects | David Klett | Animation |
| Visual Effects | Mathieu Le Meur | Animation |
| Visual Effects | Elisabeth Patte | Animation |
