De tieners Fred, Velma, Daphne en Shaggy worden beschuldigd van een grap en geschorst van Coolsville High. En hoewel ze elkaar niet kennen en hun karakters ver uiteenlopen, besluiten de vier tieners hun naam te zuiveren en samen te werken om het mysterie op te lossen. En hierbij werkt het viertal samen met de pratende detective-hond Scooby Doo.
Nee, helaas is Scooby-Doo! The Mystery Begins nog niet beschikbaar op Netflix in Nederland.
| Directing | Brian Levant | Director |
| Writing | Steven Altiere | Writer |
| Writing | Daniel Altiere | Writer |
| Production | Brian J. Gilbert | Producer |
| Editing | Eric Osmond | Editor |
| Camera | Jan Kiesser | Director of Photography |
| Sound | David Newman | Original Music Composer |
| Production | Brian Levant | Producer |
| Art | Brentan Harron | Production Design |
| Costume & Make-Up | Kate Main | Costume Design |
| Production | Harriet Greenspan | Casting |
| Production | Sean Cossey | Casting |
| Production | Stuart Aikins | Casting |
| Visual Effects | Peter V. Ware | Visual Effects Producer |
| Production | Chris Foss | Line Producer |
| Production | Chris Foss | Unit Production Manager |
| Directing | Carl Mason | First Assistant Director |
| Directing | Josy Capkun | Second Assistant Director |
| Art | Tyler Bishop Harron | Art Direction |
| Art | Victoria Söderholm | Set Decoration |
| Camera | Junichi Hosoi | "A" Camera Operator |
| Camera | Kieran Humphries | First Assistant "A" Camera |
| Camera | Carrie Wilson | Second Assistant "A" Camera |
| Camera | Karl Herrmann | "B" Camera Operator |
| Camera | Stephen J. McKnight | First Assistant "B" Camera |
| Camera | Adriene Wyse | Second Assistant "B" Camera |
| Camera | Ed Araquel | Still Photographer |
| Sound | Lars Ekstrom | Sound Mixer |
| Sound | Roderick Matte | Boom Operator |
| Sound | Ian Tarasoff | Utility Sound |
| Production | Michele MacInnes | Production Office Coordinator |
| Production | Karen Pelrine | Assistant Production Coordinator |
| Production | Melyssa Rose | Assistant Production Coordinator |
| Directing | Karin Behrenz | Third Assistant Director |
| Production | Jane Mason | Production Accountant |
| Production | Ken Brooker | Location Manager |
| Production | Paul Russell | Assistant Location Manager |
| Directing | Jules Stewart | Script Supervisor |
| Costume & Make-Up | Paulette Nelson | Assistant Costume Designer |
| Costume & Make-Up | Allison Chretien | Costumer |
| Costume & Make-Up | Moira Fentum | Costumer |
| Costume & Make-Up | April Boyes | Key Makeup Artist |
| Costume & Make-Up | Joel Echallier | Makeup Effects Designer |
| Costume & Make-Up | Danna Rutherford | Key Hair Stylist |
| Lighting | Darren McLean | Chief Lighting Technician |
| Lighting | Rory Soderman | Assistant Chief Lighting Technician |
| Lighting | Timothy Hedgecock | Rigging Gaffer |
| Camera | John Kuchera | Key Grip |
| Camera | Paul Arnel | Best Boy Grip |
| Camera | David Kershaw | Dolly Grip |
| Camera | Sylvia Pranaitis | Dolly Grip |
| Lighting | Derrick Garland | Rigging Grip |
| Art | Valentine Pavuls | Property Master |
| Art | Laura Schneider | Assistant Property Master |
| Art | D. Martin Myatt | Props |
| Art | Dean McQuillen | Construction Coordinator |
| Art | Mark McQuillen | Construction Foreman |
| Art | Roger Busque | Construction Foreman |
| Art | Dylan Dowd | Greensman |
| Art | David Manske | Set Dresser |
| Crew | Darren Marcoux | Special Effects Coordinator |
| Crew | Eric Lemay | Special Effects Coordinator |
| Crew | James Kozier | Special Effects |
| Crew | Ron Kozier | Special Effects |
| Crew | Darcy Woodley | Animal Wrangler |
| Crew | Steve Woodley | Animal Wrangler |
| Production | Natasha Tony | Extras Casting |
| Crew | Bob Dennett | Transportation Coordinator |
| Crew | Dave Byerley | Transportation Captain |
| Crew | Sean P. Aislabie | Craft Service |
| Crew | Jan Kikumoto | Post Production Supervisor |
| Crew | Wilt Henderson | Visual Effects Editor |
| Editing | Travis Dultz | First Assistant Editor |
| Visual Effects | Mark A.Z. Dippé | Visual Effects Supervisor |
| Visual Effects | Park Min-su | Visual Effects Supervisor |
| Sound | Mark A. Rozett | Sound Re-Recording Mixer |
| Sound | Kelly Vandever | Sound Re-Recording Mixer |
| Sound | Trip Brock | Supervising Sound Editor |
| Sound | Steven Avila | Sound Designer |
| Sound | Steven Avila | Sound Effects Editor |
| Sound | Peter D. Lago | Sound Designer |
| Sound | Peter D. Lago | Sound Effects Editor |
| Sound | Jason Shaffer | Sound Effects Editor |
| Sound | Alexander Pugh | Sound Effects Editor |
| Sound | Bryon Speller | Dialogue Editor |
| Sound | Brian S.M. Wroth | Dialogue Editor |
| Sound | Doug Latislaw | ADR Mixer |
| Sound | Ben Whitver | ADR Mixer |
| Sound | Steven Utt | Assistant Sound Editor |
| Sound | Kyle Tilbury | Assistant Sound Editor |
| Sound | Sean Madsen | Assistant Sound Editor |
| Sound | Caleb Easter | Foley Editor |
| Sound | Zac Anderson | Foley Editor |
| Sound | Greg Mauer | Foley Mixer |
| Sound | Rick Owens | Foley Artist |
| Editing | Sue Gates | Colorist |
| Crew | Owen Walstrom | Stunts |
