Het avontuur begint met het verschijnen van Mewtwo, een genetisch gemanipuleerde Pokémon, gecreëerd uit het DNA van Mew, de zeldzaamste van alle Pokémon. Mewtwo is vastbesloten om zijn superioriteit te bewijzen en verleidt Ash, Pikachu en de anderen in een strijd, zoals er nog nooit is geweest: Mewtwo tegen Mew, superkloon tegen Pokémon. Het gaat hier om de ultieme confrontatie met de toekomst van de wereld als inzet.
Nee, helaas is Pokémon: de film - Mewtwo tegen Mew nog niet beschikbaar op Netflix in Nederland.
| Directing | Kunihiko Yuyama | Director |
| Writing | Takeshi Shudo | Screenplay |
| Production | Choji Yoshikawa | Producer |
| Camera | Hisao Shirai | Director of Photography |
| Writing | Satoshi Tajiri | Original Story |
| Sound | Shinji Miyazaki | Music |
| Sound | Hirokazu Tanaka | Music |
| Visual Effects | Izumi Shimura | Animation Director |
| Visual Effects | Sayuri Ichiishi | Character Designer |
| Art | Kunihiko Yuyama | Storyboard Artist |
| Visual Effects | Fumiyo Kimura | Key Animation |
| Visual Effects | Yuzo Sato | Key Animation |
| Visual Effects | Satoshi Kubo | Key Animation |
| Visual Effects | Yasuhide Maruyama | Key Animation |
| Visual Effects | Katsuichi Nakayama | Key Animation |
| Visual Effects | Akiko Nakamura | Key Animation |
| Visual Effects | Kaori Kunii | Key Animation |
| Visual Effects | Masao Nakata | Key Animation |
| Visual Effects | Yuriko Chiba | Key Animation |
| Visual Effects | Junko Isaka | Key Animation |
| Visual Effects | Masami Takebuchi | Key Animation |
| Visual Effects | Tomoko Takei | Key Animation |
| Visual Effects | Midori Nagaoka | Key Animation |
| Visual Effects | Masahiro Sekiguchi | Key Animation |
| Visual Effects | Masao Suwa | Key Animation |
| Visual Effects | Tsunenaka Nozaki | Key Animation |
| Visual Effects | Yoshihiro Nagamori | Key Animation |
| Visual Effects | Midori Yamakubo | Key Animation |
| Visual Effects | Tetsuro Kaku | Key Animation |
| Visual Effects | Yumi Chiba | Key Animation |
| Visual Effects | Yoshihiro Osugi | Key Animation |
| Visual Effects | Nori Nakamura | Key Animation |
| Visual Effects | Hiroshi Kawaguchi | Key Animation |
| Visual Effects | Masaya Fujimori | Key Animation |
| Visual Effects | Koji Fukasawa | Key Animation |
| Visual Effects | Katsuyuki Tamura | Key Animation |
| Visual Effects | Kazuaki Mori | Key Animation |
| Visual Effects | Takuya Matsumoto | Key Animation |
| Visual Effects | Masatsugu Takeda | Key Animation |
| Visual Effects | Yuji Mukoyama | Key Animation |
| Visual Effects | Shoichi Masuo | Key Animation |
| Visual Effects | Eiko Saito | Key Animation |
| Visual Effects | Hiroko Kazui | Key Animation |
| Visual Effects | Kazumi Sato | Key Animation |
| Visual Effects | Hiromi Niioka | Key Animation |
| Visual Effects | Satoru Iriyoshi | Key Animation |
| Visual Effects | Satomi Kitahara | Key Animation |
| Visual Effects | Mamiko Nakanishi | Key Animation |
| Visual Effects | Hideaki Maniwa | Key Animation |
| Visual Effects | Toshiharu Kumaoka | Key Animation |
| Visual Effects | Tadaaki Miyata | Key Animation |
| Visual Effects | Etsuhito Mori | Key Animation |
| Visual Effects | Masaaki Iwane | Key Animation |
| Visual Effects | Izumi Shimura | Key Animation |
| Visual Effects | Masaru Fukumoto | Animation Director |
| Visual Effects | Eikichi Takahashi | Animation Director |
| Visual Effects | Masaya Fujimori | Animation Director |
| Visual Effects | Yoshiaki Yanagida | Animation Director |
| Visual Effects | Shunya Yamada | Animation Director |
| Visual Effects | Norihiro Matsubara | Animation Director |
