FBI-agent Malcolm Turner is op jacht naar een ontsnapte bankrover die vermoedelijk naar het huis van Big Momma zal gaan, de grootmoeder van diens knappe ex-vriendin Sherry. Wanneer Big Momma plotseling op reis gaat, dreigt het plan te mislukken en is het aan Malcolm om de rol van de spraakmakende oma over te nemen. Malcolm heeft alles onder controle, behalve wanneer hij verliefd wordt op Sherry.
Nee, helaas is Big Momma's House nog niet beschikbaar op Netflix in Nederland.
| Writing | Don Rhymer | Screenplay |
| Production | Martin Lawrence | Executive Producer |
| Sound | Richard Gibbs | Original Music Composer |
| Production | Jeff Kwatinetz | Executive Producer |
| Production | David T. Friendly | Producer |
| Writing | Darryl Quarles | Screenplay |
| Editing | Bruce Green | Editor |
| Production | Michael Green | Producer |
| Editing | Kent Beyda | Editor |
| Camera | Michael D. O'Shea | Director of Photography |
| Sound | Doug Hemphill | Sound Re-Recording Mixer |
| Art | Mariko Braswell | Set Designer |
| Directing | Richard Graves | First Assistant Director |
| Sound | Thomas Causey | Sound Mixer |
| Sound | Robert Grieve | Supervising Sound Editor |
| Art | Kathleen Walker | Art Department Coordinator |
| Art | Randy Moore | Art Direction |
| Costume & Make-Up | Frank Perry Rose | Costume Supervisor |
| Crew | Ernie F. Orsatti | Stunt Coordinator |
| Art | Ellen Totleben | Set Decoration |
| Art | David T. Cannon | Construction Coordinator |
| Art | Rudy Reachi | Property Master |
| Sound | Yann Delpuech | Supervising Sound Editor |
| Camera | Jeff Case | Key Grip |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Crew | Billy G. Arter | Transportation Coordinator |
| Directing | Susan J. Hellmann | Second Assistant Director |
| Directing | Benita Brazier | Script Supervisor |
| Crew | Larry Fioritto | Special Effects Coordinator |
| Art | Charisse Cardenas | Set Designer |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | David Leitch | Stunts |
| Production | Arnon Milchan | Executive Producer |
| Crew | Tony R. Medina | Propmaker |
| Costume & Make-Up | Todd Tucker | Special Effects Makeup Artist |
| Directing | Raja Gosnell | Director |
| Costume & Make-Up | Francine Jamison-Tanchuck | Costume Design |
| Writing | Darryl Quarles | Story |
| Production | Nancy Klopper | Casting |
| Art | Craig Stearns | Production Design |
