De wetenschapper J. Robert Oppenheimer leidt het zeer geheime Manhattanproject. Onder meer de Hongaarse wetenschapper Edward Teller, die de waterstofbom uitvindt, werkt eraan mee. Oppenheimer is getrouwd met Katherine, maar heeft een affaire met Jean Tatlock, een lid van de Communistische Partij. De overheid acht haar gevaarlijk voor de belangen van de Amerikaanse veiligheid. Oppenheimer is uiteindelijk verantwoordelijk voor de uitvinding van de atoombom.
| Art | Andrew W. Bofinger | Set Decoration Buyer |
| Sound | Alex Gibson | Sound Effects Editor |
| Crew | George Cottle | Stunt Coordinator |
| Art | Aaron Hurvitz | Location Scout |
| Production | Dennis Muscari | Location Manager |
| Art | Noelle King | Set Designer |
| Camera | M. Shane Cates | Grip |
| Camera | Jaron Whitfill | Camera Technician |
| Visual Effects | Ernest Nelms | Imaging Science |
| Directing | Christopher Nolan | Director |
| Production | Christopher Nolan | Producer |
| Production | Emma Thomas | Producer |
| Writing | Christopher Nolan | Writer |
| Editing | Jennifer Lame | Editor |
| Production | Charles Roven | Producer |
| Sound | Ludwig Göransson | Original Music Composer |
| Camera | Hoyte van Hoytema | Director of Photography |
| Sound | Richard King | Sound Designer |
| Crew | Gary Thomas Williams | Driver |
| Art | Jonas Kirk | Construction Coordinator |
| Art | Ruth De Jong | Production Design |
| Visual Effects | Scott R. Fisher | Special Effects Supervisor |
| Production | John Papsidera | Casting |
| Costume & Make-Up | Ellen Mirojnick | Costume Design |
| Art | Easton Michael Smith | Set Designer |
| Visual Effects | Andrew Jackson | Visual Effects Supervisor |
| Art | Adam Willis | Set Decoration |
| Art | Tammy S. Lee | Set Designer |
| Costume & Make-Up | Heidi M. Baca | Hairstylist |
| Crew | Patrick Baker | Driver |
| Sound | Willie D. Burton | Sound Mixer |
| Visual Effects | Mike Duffy | Visual Effects Producer |
| Crew | Terry Jackson | Stunts |
| Crew | Mark Norby | Stunts |
| Sound | Adam Mohundro | Boom Operator |
| Crew | Steve DeCastro | Stunts |
| Crew | Danny Downey | Stunts |
| Sound | Dan O'Connell | Foley Artist |
| Crew | Nick LaRocca | Stunts |
| Sound | Doug Shamburger | Boom Operator |
| Production | Rafael Lima | Unit Production Manager |
| Sound | Russell Farmarco | Dialogue Editor |
| Sound | Andrew Bock | First Assistant Sound Editor |
| Visual Effects | Mike Chambers | Visual Effects Producer |
| Visual Effects | Giacomo Mineo | Visual Effects Supervisor |
| Visual Effects | Stephen Parsey | Visual Effects Production Manager |
| Crew | Josh Lakatos | Stunt Driver |
| Crew | Derek Lacasa | Stunt Double |
| Sound | Christopher Flick | Foley Editor |
| Sound | Kevin O'Connell | Sound Re-Recording Mixer |
| Crew | Dean Bailey | Stunt Driver |
| Costume & Make-Up | Marta Trudnowska | Set Costumer |
| Production | Anthony Del Grosso | Location Assistant |
| Production | Scott Riddle | Assistant Location Manager |
| Editing | Ray Boniker | Assistant Editor |
| Art | Rory Higgs | Location Scout |
| Crew | Kevin Caira | Transportation Coordinator |
| Crew | Jeremy Whalon | Driver |
| Editing | James A. Brewer | Assistant Editor |
| Production | Marissa Nodar | Assistant Location Manager |
| Costume & Make-Up | Brittnee Holmquist | Costumer |
| Production | Michael D. Sullivan | Assistant Location Manager |
| Costume & Make-Up | Josh Mar | Set Costumer |
| Costume & Make-Up | Anya Zebroski | Costumer |
| Production | Shannon Blaney | Assistant Location Manager |
| Production | Michael Edward Smith | Location Manager |
| Costume & Make-Up | Dianna Warren | Seamstress |
| Production | Patty Carey | Location Manager |
| Costume & Make-Up | Mary Bowman | Set Costumer |
| Costume & Make-Up | Mallory Bradley | Costumer |
| Costume & Make-Up | Cheryl Cravedi | Set Costumer |
| Costume & Make-Up | Jo Kissack Folsom | Assistant Costume Designer |
| Editing | Tom Foligno | First Assistant Editor |
| Production | Eric Maldonado | Assistant Location Manager |
| Costume & Make-Up | Katie L. Murphy | Key Costumer |
| Editing | Nick Ellsberg | First Assistant Editor |
| Costume & Make-Up | Rebecca Leigh Adams | Set Costumer |
| Production | Douglass Jamison | Assistant Location Manager |
| Art | Hilton Clay Peres | Location Scout |
| Costume & Make-Up | Sabrina Calley | Costumer |
| Costume & Make-Up | Wynema Chavez | Ager/Dyer |
| Editing | Scott Wesley Ross | Assistant Editor |
| Editing | Michael T. Wilson | Assistant Editor |
| Crew | Kaiser Clark | Driver |
| Costume & Make-Up | Lynda Foote | Costume Supervisor |
| Costume & Make-Up | Alice Pico | Costumer |
| Costume & Make-Up | Meg Burke | Costumer |
| Editing | Andrew Blustain | Assistant Editor |
| Directing | Steve Gehrke | Script Supervisor |
| Crew | Patrick D. Baker | Driver |
| Editing | Jay Trautman | Assistant Editor |
| Costume & Make-Up | Christy Falco | Key Makeup Artist |
| Costume & Make-Up | Ahou Mofid | Key Hair Stylist |
| Art | Greg Finnin | Assistant Property Master |
| Art | William M. Lynch | Art Department Assistant |
| Art | Heather Elwell | Art Department Coordinator |
| Art | Frank Piercy | Painter |
| Art | Guillaume DeLouche | Property Master |
| Directing | Dixon McPhillips | Second Assistant Director |
| Art | Jason McDonough | Leadman |
| Costume & Make-Up | Lydia Fantini | Hairstylist |
| Directing | Nilo Otero | First Assistant Director |
| Crew | Taylor Estevez | Propmaker |
| Art | Justin O'Neal Miller | Set Designer |
| Art | Bianca Medina-Montoya | Assistant Set Decoration |
| Art | Joshua Sankar | Graphic Designer |
| Art | Rachel Nowik | Assistant Property Master |
| Art | Robert Aguirre | Assistant Art Director |
| Art | Lauren Kelley | Art Department Assistant |
| Art | Jim Hewitt | Set Designer |
| Art | Bruno F. Panacciulli | Construction Coordinator |
| Art | Liliia Radchenko | Props |
| Costume & Make-Up | Andrea Steele | Makeup Artist |
| Directing | Jesse Carmona | Second Second Assistant Director |
| Crew | Maxwell Graves | Carpenter |
| Art | Mark Gutierrez | Construction Foreman |
| Art | Roxy Hua | Assistant Art Director |
| Directing | Richard Molloy | Additional Second Assistant Director |
| Directing | Andrew Stahl | Second Assistant Director |
| Art | Geoff Dillow | Set Dresser |
| Art | Susanne Mueller | Set Decoration Buyer |
| Camera | Hans Bjerno | Aerial Director of Photography |
| Lighting | Joe Vitellaro | Rigging Grip |
| Lighting | Giovanni Zelko | Lighting Technician |
| Art | Michael Thurman | Set Dresser |
| Camera | Carlo Corbin | Grip |
| Camera | Kelly A. Cook | Still Photographer |
| Art | Amy Wallenberg | Set Decoration Buyer |
| Camera | Melinda Sue Gordon | Still Photographer |
| Art | Susu Schwaber | Art Department Assistant |
| Lighting | Leigh Mierke | Lighting Technician |
| Art | Scott b Schmidt | Set Dresser |
| Camera | Manning Tillman | First Assistant "B" Camera |
| Lighting | Satoshi Yamazaki | Key Rigging Grip |
| Art | Jake Cavallo | Assistant Art Director |
| Art | Richard Lieberman | Props |
| Camera | Keith B. Davis | First Assistant "A" Camera |
| Camera | Reese Price | Grip |
| Lighting | Aaron Schulte | Electrician |
| Lighting | Francisco Sonic Kim | Rigging Grip |
| Art | Anthony Whitman | Set Decoration Buyer |
| Camera | Kyle Carden | Key Grip |
| Camera | Jason Gary | Best Boy Grip |
| Camera | Ryan Monro | Dolly Grip |
| Camera | Eric Dvorsky | Aerial Camera Technician |
| Lighting | Steve Zvorsky | Electrician |
| Lighting | Jacob Bogatin | Lighting Technician |
| Camera | Simon Firsht | Additional Director of Photography |
| Camera | Brian Udoff | Additional First Assistant Camera |
| Art | Michael Timman | Set Dresser |
| Camera | Sara Elia | Grip |
| Lighting | Paul Crow Willis | Key Rigging Grip |
| Crew | David Croley Broyles | Set Production Assistant |
| Writing | Kai Bird | Book |
| Writing | Martin J. Sherwin | Book |
| Art | Claire Kaufman | Set Decoration |
| Costume & Make-Up | Luisa Abel | Makeup Department Head |
| Sound | Gary Rizzo | Sound Re-Recording Mixer |
| Crew | Jolene Van Vugt | Stunt Driver |
| Costume & Make-Up | Eric Luling | On Set Dresser |
| Crew | Daniel Benjamin | Studio Teacher |
| Costume & Make-Up | Kerrin Jackson | Makeup Artist |
| Costume & Make-Up | Jaime Leigh McIntosh | Hair Department Head |
| Crew | Laurie Pellard | Special Effects |
| Visual Effects | Ivelina Dobreva | Compositing Supervisor |
| Crew | Ashley Mohabir | Compositor |
| Production | Thomas Hayslip | Executive Producer |
| Production | James Woods | Executive Producer |
| Production | J. David Wargo | Executive Producer |
| Production | Andy Thompson | Co-Producer |
| Production | Nathan Kelly | Unit Production Manager |
| Production | Thomas Hayslip | Unit Production Manager |
| Editing | Mike Fay | Additional Editor |
| Crew | Duffy Gaver | Stunts |
| Costume & Make-Up | Jennifer Tremont | Hairstylist |
| Costume & Make-Up | Danielle Vigil | Hairstylist |
| Costume & Make-Up | Jason Hamer | Prosthetic Designer |
| Art | Samantha Englender | Supervising Art Director |
| Art | Chris Larsen | Set Dresser |
| Crew | David Eisen | Driver |
