Dr. Misty Calhoun wordt gevraagd mee te werken aan een topgeheim experiment. Tijdens het experiment zullen haaien genetisch gemanipuleerd worden in een laboratorium onder water. Aan het hoofd staat Carl Durant, een miljardair die zijn vermogen verdiend heeft met medicijnen.
Nee, helaas is Deep Blue Sea 2 nog niet beschikbaar op Netflix in Nederland.
| Directing | Darin Scott | Director |
| Production | Tom Siegrist | Producer |
| Camera | Thomas L. Callaway | Director of Photography |
| Writing | Hans Rodionoff | Story |
| Production | Harriet Greenspan | Casting |
| Art | Franz Lewis | Production Design |
| Editing | Michael Trent | Editor |
| Production | David Wicht | Co-Producer |
| Production | Tom Keniston | Executive Producer |
| Sound | Sean Murray | Original Music Composer |
| Directing | Andre Weavind | First Assistant Director |
| Sound | Claire Hesom | Boom Operator |
| Visual Effects | Byron Tofas | Compositing Lead |
| Visual Effects | Marco Raposo de Barbosa | Visual Effects Supervisor |
| Camera | Guy Hodgen | "B" Camera Operator |
| Camera | Riyaad Majiet | Best Boy Grip |
| Camera | Mark Forster | Key Grip |
| Editing | Matt McFarland | Digital Intermediate Colorist |
| Sound | Barry Donnelly | ADR Recordist |
| Sound | Travis Crotts | Foley Editor |
| Crew | Darrin Hofmeyr | CG Supervisor |
| Crew | Dylan Palmboom | Compositor |
| Camera | Sven Vosloo | Second Unit Director of Photography |
| Crew | Fraser James | Marine Coordinator |
| Crew | Norman Jardim | Carpenter |
| Visual Effects | Tyla Koen | Digital Compositor |
| Visual Effects | Douw van Niekerk | Digital Compositor |
| Writing | Hans Rodionoff | Teleplay |
| Writing | Erik Patterson | Teleplay |
| Crew | Angelo Beceiro Collinicos | Compositor |
| Crew | Helene Turvey | Unit Publicist |
| Costume & Make-Up | Dihantus Engelbrecht | Costume Design |
| Costume & Make-Up | Juanette Van Der Merwe | Key Makeup Artist |
| Art | Hugo Queiroga | Construction Manager |
| Crew | Maria Friesen | Visual Effects Editor |
| Crew | Stephanie Traut | Visual Effects Editor |
| Directing | Ashley Aldworth | Script Supervisor |
| Art | Shakeela Kingzley | Art Department Coordinator |
| Visual Effects | Max Poolman | Special Effects Supervisor |
| Visual Effects | Marc Bloch | Visual Effects Supervisor |
| Camera | Jonathan Kyle | Focus Puller |
| Lighting | Moses Makateng | Electrician |
| Writing | Jessica Scott | Teleplay |
| Crew | Lise-Marie Bothma | Special Effects Coordinator |
| Sound | Travis Crotts | Dialogue Editor |
| Lighting | Guy Stallard | Gaffer |
| Production | Johan van Huyssteen | Location Manager |
| Camera | Roderick Dean Smith | Key Grip |
| Sound | Jason Oliver | ADR Mixer |
| Crew | Sven Hohmeier | Compositor |
| Visual Effects | Annel Rautenbach | Digital Compositor |
| Camera | Damien Walsh | Focus Puller |
| Camera | Brendon Bennett | Underwater Camera |
| Sound | Christopher M. Foster | Music Editor |
| Sound | Clayton Weber | Supervising Sound Editor |
| Camera | Lwazi Jokazi | Assistant Grip |
| Camera | Anele Thobi | Assistant Grip |
| Camera | Ezra Van Schalkwyk | Camera Loader |
| Lighting | Julius Ndakwa | Electrician |
| Editing | Bruce Lomet | Digital Intermediate Producer |
| Camera | Jan Du Toit | Epk Camera Operator |
| Art | Mark Risk | Storyboard Artist |
| Visual Effects | David Jose Ferreira | Digital Compositor |
| Visual Effects | Mathapo Tlou | Digital Compositor |
| Visual Effects | Carelize Jacobs | Digital Compositor |
| Camera | Jason Venter | Best Boy Grip |
| Camera | Nigel Tompkins | Digital Imaging Technician |
| Camera | Wayne Richards | Grip |
| Production | Craig Swanepoel | Extras Casting |
| Costume & Make-Up | Niqui da Silva | Makeup Designer |
| Camera | Casey van der Touw | Camera Loader |
| Camera | Adrian Boerlage | First Assistant Camera |
| Costume & Make-Up | Misha du Toit | Costume Supervisor |
| Sound | Fred Paragano | Sound Re-Recording Mixer |
| Sound | Clayton Weber | Sound Re-Recording Mixer |
| Lighting | Justice Amadi | Electrician |
| Visual Effects | Christopher Bekker | Digital Compositor |
| Camera | Sven Vosloo | "A" Camera Operator |
| Camera | Zaheer Ismail | Grip |
| Sound | Kurt Godwin | Sound Mix Technician |
| Writing | Wayne Powers | Characters |
| Writing | Donna Powers | Characters |
| Writing | Duncan Kennedy | Characters |
| Editing | Kyle Landman | Dailies Operator |
| Editing | Christopher Obal | Digital Intermediate Editor |
| Costume & Make-Up | Carren Marchant | Costume Standby |
| Lighting | Gilles Boisacq | Gaffer |
| Production | Riaan Cordier | Production Accountant |
| Production | Shannyn Zorab | Production Assistant |
| Production | Mayra Garcia | Production Coordinator |
| Visual Effects | Hein Oosthuizen | 3D Artist |
