De in Pakistaan geboren Kumail heeft een relatie met een Amerikaanse vrouw, Emily. Samen moet ze de verwachtingen zien te overwinnen van zijn familie en hun 1400 jaar oude tradities. Zijn ouders blijven hem onophoudelijk bestoken met potentiële bruiden voor een gearrangeerd huwelijk.
Nee, helaas is The Big Sick nog niet beschikbaar op Netflix in Nederland.
| Directing | Michael Showalter | Director |
| Production | Judd Apatow | Producer |
| Production | Barry Mendel | Producer |
| Camera | Cliff Alphonse | Grip |
| Production | Jeremy Kipp Walker | Executive Producer |
| Sound | Michael Andrews | Original Music Composer |
| Camera | Brian Burgoyne | Director of Photography |
| Art | Brandon Tonner-Connolly | Production Design |
| Editing | Robert Nassau | Editor |
| Sound | Joe Rudge | Music Supervisor |
| Production | Jeremy Kipp Walker | Unit Production Manager |
| Camera | Andrew Juhl | First Assistant Camera |
| Camera | Sally Foster | Grip |
| Sound | Junior Cyrus Baron | Utility Sound |
| Crew | Robert Maasin | Set Production Assistant |
| Sound | Tom Paul | Sound Re-Recording Mixer |
| Visual Effects | Constance Conrad | Digital Compositors |
| Production | Glen Basner | Executive Producer |
| Camera | Frank Larson | Camera Operator |
| Camera | Pierrot Colonna | Camera Operator |
| Costume & Make-Up | Maeve Kelly | Assistant Costume Designer |
| Crew | Michael Jackman | Post Production Supervisor |
| Sound | Azniv Korkejian | Music Editor |
| Visual Effects | Melissa Kivell | VFX Production Coordinator |
| Camera | Htat Htut | First Assistant Camera |
| Costume & Make-Up | Raquel Vivve | Makeup Artist |
| Crew | Jon Santo | Set Production Assistant |
| Sound | Mark Linden | Sound Re-Recording Mixer |
| Production | Cynthia Chou | Production Coordinator |
| Sound | Jerry 'Niru' Cox | Boom Operator |
| Costume & Make-Up | Tonia Ciccone | Hair Department Head |
| Crew | Matthew McCoubry | Set Production Assistant |
| Crew | Matt Merksamer | Set Production Assistant |
| Crew | Ed Elliot | Driver |
| Sound | Dan Edelstein | ADR Editor |
| Sound | Pam DeMetruis-Thomas | Foley Editor |
| Camera | Anthony F. Gamiello | Grip |
| Lighting | Francesco Pinna | Best Boy Electric |
| Art | Shane Aitchison | Art Department Coordinator |
| Crew | Brad Gage | Actor's Assistant |
| Sound | Tom Paul | Supervising Sound Editor |
| Production | Adam Kersh | Publicist |
| Production | Amanda Glaze | Co-Producer |
| Production | Annie Tan | Production Supervisor |
| Camera | Ari Issler | Camera Operator |
| Crew | Mike Mcelroy | Driver |
| Editing | Luis Cuevas | Assistant Editor |
| Camera | Alec Jarnagin | Steadicam Operator |
| Camera | Nicole Rivelli | Still Photographer |
| Camera | Fillip Penson | First Assistant Camera |
| Art | Andy Eklund | Art Direction |
| Costume & Make-Up | Leo Won | Makeup Department Head |
| Crew | Alex Spear | Set Production Assistant |
| Crew | George Holtzer | Transportation Captain |
| Production | Aaron Schoonover | Casting Associate |
| Crew | Peter Link | Driver |
| Crew | PJ Ford | Driver |
| Crew | Mike Devereaux | Driver |
| Art | Aaron Becker | Title Designer |
| Directing | Nicholas Bell | First Assistant Director |
| Costume & Make-Up | Megan Sanders | Wardrobe Supervisor |
| Art | Anthony S. Calypso | Assistant Property Master |
| Sound | Paul Reed | Utility Sound |
| Crew | Adrienne Enderle | Set Production Assistant |
| Crew | Yadeed Mellman | Set Production Assistant |
| Crew | Lauren Meckleberg | Set Production Intern |
| Production | Dann Fink | ADR Voice Casting |
| Sound | Bill Orrico | Dialogue Editor |
| Production | Gayle Keller | Casting |
| Camera | Parissh McClean | Grip |
| Art | Jack Mortellaro Jr. | Leadman |
| Art | Anthony Taratunio | Set Dresser |
| Lighting | Jason Velez | Gaffer |
| Crew | Jeff Brink | Special Effects Coordinator |
| Costume & Make-Up | Kirsten Sylvester | Key Makeup Artist |
| Production | Johnny Holland | Production Accountant |
| Crew | Isaac Gotterer | Set Production Intern |
| Editing | Leah Tuscano | Assistant Editor |
| Visual Effects | Neal Jones | Visual Effects |
| Directing | Adam J. Bernard | Second Assistant Director |
| Camera | Larhn Laurens Davitt | Dolly Grip |
| Crew | Roberto González Arévalo | Production Office Assistant |
| Crew | Damon Tragni | Driver |
| Production | Bruce Winant | ADR Voice Casting |
| Art | Richard Hebrank | Construction Coordinator |
| Crew | Anthony Pennachio | Set Production Assistant |
| Crew | Alex Lilja | Set Production Assistant |
| Production | Allison Kirschner | Casting Associate |
| Crew | Ryan Murphy | Driver |
| Crew | Mike Murphy | Driver |
| Sound | Bobby Mackston | Sound Editor |
| Production | Ben Browning | Executive Producer |
| Production | Kumail Nanjiani | Executive Producer |
| Crew | Jeremy Sample | Stunt Coordinator |
| Directing | Mariana Hellmund | Script Supervisor |
| Camera | Yousheng Tang | Steadicam Operator |
| Camera | Nuno Oliveira | Grip |
| Art | Bill C. Bishop | Leadman |
| Production | Nicki Slack | Assistant Production Coordinator |
| Production | Jillian Stricker | Location Manager |
| Production | Nicole P. Hearon | Casting Associate |
| Sound | Sean Garnhart | Sound Effects Editor |
| Visual Effects | Fangge Chen | Digital Compositors |
| Production | Emily V. Gordon | Executive Producer |
| Costume & Make-Up | Toni Roman-Grimm | Key Hair Stylist |
| Costume & Make-Up | Bert Reo Anderson | Hairstylist |
| Crew | Ava Myint | Set Production Intern |
| Crew | Bob Papini JR | Driver |
| Visual Effects | Saffia Rahimtoola | Digital Compositors |
| Camera | Brent Poleski | Key Grip |
| Art | Elizabeth Rodrick | Set Decoration |
| Costume & Make-Up | Lauren Colbert | Costume Coordinator |
| Crew | Jasmine Brotzman | Set Production Assistant |
| Crew | Ella Gibney | Set Production Intern |
| Costume & Make-Up | Christina Nickas | Wardrobe Supervisor |
| Crew | Jocelyn Magsumbol | Production Office Assistant |
| Costume & Make-Up | Josh Gericke | Hairstylist |
| Crew | Liz Wagner | Set Production Assistant |
| Visual Effects | Lucien Harriot | VFX Supervisor |
| Art | William Smith | Set Dresser |
| Art | Lauren J. Brown | Property Master |
| Sound | Charles R. Hunt | Production Sound Mixer |
| Editing | Zach Wolf | Assistant Editor |
| Crew | Michael Elliott | Transportation Co-Captain |
| Crew | Joe Schultz | Driver |
| Writing | Kumail Nanjiani | Screenplay |
| Writing | Emily V. Gordon | Screenplay |
| Costume & Make-Up | Sarah Mae Burton | Costume Designer |
| Sound | Tara A. Paul | Sound Re-Recording Mixer |
