Graham en Clive zijn twee vrienden die enorm gek zijn op stripboeken en vooral interesse hebben in science-fiction verhalen. Samen gaan ze op reis naar het UFO-centrum van Amerika, namelijk het beruchte "Area 51" in Nevada. Als ze midden in de woestijn zijn komen ze een voortvluchtige Alien tegen, genaamd Paul (Seth Rogen).
| Directing | Greg Mottola | Director |
| Writing | Nick Frost | Writer |
| Writing | Simon Pegg | Writer |
| Production | Nira Park | Producer |
| Production | Tim Bevan | Producer |
| Production | Eric Fellner | Producer |
| Production | Liza Chasin | Executive Producer |
| Production | Debra Hayward | Executive Producer |
| Production | Natascha Wharton | Executive Producer |
| Camera | Lawrence Sher | Director of Photography |
| Art | Jefferson Sage | Production Design |
| Visual Effects | Jody Johnson | Visual Effects Supervisor |
| Visual Effects | Anders J.L Beer | Animation Supervisor |
| Visual Effects | Hal Couzens | Visual Effects Supervisor |
| Sound | Peter F. Kurland | Sound mixer |
| Production | Cheryl Kurk | Production Accountant |
| Production | S. Todd Christensen | Location Manager |
| Art | Carla Curry | Set Decoration |
| Crew | Tania Blunden | Post Production Supervisor |
| Editing | Catriona Richardson | First Assistant Editor |
| Crew | Andy Hague | Visual Effects Editor |
| Sound | Julian Slater | Supervising Sound Editor |
| Sound | Nick Angel | Music Supervisor |
| Editing | Chris Dickens | Editor |
| Production | Robert Graf | Executive Producer |
| Production | Robert Graf | Unit Production Manager |
| Production | Allison Jones | Casting |
| Sound | David Arnold | Original Music Composer |
| Costume & Make-Up | Nancy Steiner | Costume Design |
| Camera | Wilson Webb | Still Photographer |
| Production | Rachael Lin Gallaghan | Production Coordinator |
| Production | Kate Fasulo | Production Coordinator |
| Crew | Darrin Prescott | Stunt Coordinator |
| Art | Richard Fojo | Art Direction |
| Sound | Dina Eaton | Music Editor |
| Sound | Steven Price | Music Editor |
| Costume & Make-Up | Linda Matthews | Costume Supervisor |
| Costume & Make-Up | Jennifer Starzyk | Assistant Costume Designer |
| Camera | John Joyce | Steadicam Operator |
| Camera | Brooks Robinson | Steadicam Operator |
| Lighting | Jarred Waldron | Gaffer |
| Lighting | Glenn E. Moran | Rigging Gaffer |
| Sound | Chris Burdon | Sound Re-Recording Mixer |
| Sound | Doug Cooper | Sound Re-Recording Mixer |
| Sound | Simon Gershon | Sound Effects Editor |
| Sound | Ben Meechan | Sound Effects Editor |
| Costume & Make-Up | Geordie Sheffer | Hair Department Head |
| Costume & Make-Up | Tarra D. Day | Makeup Department Head |
| Costume & Make-Up | Nina Paskowitz | Hairstylist |
| Costume & Make-Up | Mary Burton | Makeup Artist |
| Costume & Make-Up | Berlinda Cantu-Lewis | Hairstylist |
| Costume & Make-Up | Jane Walker | Hairstylist |
| Crew | Sonny Surowiec | Stunts |
| Writing | Edgar Wright | Script Editor |
| Sound | Kirsten Lane | Music Consultant |
| Crew | Debbie Evans | Stunts |
| Crew | Richard Ayoade | Thanks |
| Crew | Tad Griffith | Stunts |
| Crew | Chris Palermo | Stunt Driver |
| Sound | Peter Burgis | Foley Artist |
| Sound | Peter Gleaves | ADR Mixer |
| Sound | Ruth Sullivan | Foley Artist |
| Sound | Barnaby Smyth | Foley Artist |
| Production | Adam Schardein | Producer |
| Costume & Make-Up | Greg Nicotero | Special Effects Makeup Artist |
| Costume & Make-Up | Natasha Ladek | Wigmaker |
| Costume & Make-Up | Georgia Allen | Makeup Artist |
| Crew | Al Goto | Stunts |
| Crew | Ed Duran | Stunts |
| Crew | Tait Fletcher | Stunts |
| Crew | Dean Bailey | Stunts |
| Crew | Donny Bailey | Stunts |
| Crew | Elle Alexander | Stunts |
| Crew | Bruce Benson | Stunts |
| Crew | Mark Brooks | Stunts |
| Crew | Robert Anthony Brass | Stunts |
| Crew | Bobby Burns | Stunts |
| Crew | Eddie Fiola | Stunts |
| Crew | Laurence Chavez | Stunts |
| Crew | Nate Harris | Stunts |
| Crew | Michael R. Long | Stunts |
| Crew | Cory Fleming | Stunts |
| Crew | Rich Minga | Stunts |
| Crew | Suzanne Prescott | Stunts |
| Crew | Angelique Midthunder | Stunts |
| Crew | Derick Pritchard | Stunts |
| Crew | Rich Rutherford | Stunts |
| Crew | Jimmy Romano | Stunts |
| Crew | Trina Siopy | Stunts |
| Crew | Willie Weber | Stunts |
| Crew | Craig Baxley Jr | Stunts |
| Crew | Mam Smith | Stunts |
