Wanneer een onbekende, vermoedelijk een mutant met buitengewone krachten, de president aanvalt krijgen de mutanten met nog meer argwaan en discriminatie te maken dan al het geval was. Er komt bredere steun in de samenleving voor een registratieplicht voor mutanten. Militair leider William Stryker is één van de grootste voorstanders van dit plan, en leidt een aanval op de X-Men opleiding. De ontsnapte Magneto begint een opmerkelijke samenwerking met Professor Xavier om Stryker te stoppen. Ondertussen begint Wolverine een onderzoek naar zijn verleden.
Nee, helaas is X-Men 2 nog niet beschikbaar op Netflix in Nederland.
| Writing | Michael Dougherty | Screenplay |
| Writing | Dan Harris | Screenplay |
| Writing | David Hayter | Story |
| Crew | Terry Notary | Choreographer |
| Writing | Zak Penn | Story |
| Writing | Bryan Singer | Story |
| Directing | Bryan Singer | Director |
| Writing | David Hayter | Screenplay |
| Editing | Elliot Graham | Co-Editor |
| Production | Jason McGatlin | Production Supervisor |
| Directing | Lee Cleary | First Assistant Director |
| Art | Franziska Keller | Art Department Coordinator |
| Costume & Make-Up | Gordon J. Smith | Special Effects Makeup Artist |
| Art | Barbara Wilson | Assistant Art Director |
| Sound | Rob Young | Sound Mixer |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Art | Jason B. Landels | Assistant Property Master |
| Camera | Tim Merkel | Steadicam Operator |
| Camera | Sean M. Harding | First Assistant "B" Camera |
| Sound | Susan Dawes | Dialogue Editor |
| Production | Ross T. Fanger | Unit Production Manager |
| Editing | Dov Samuel | First Assistant Editor |
| Directing | David Arnold | Second Assistant Director |
| Sound | Michael Herbick | Sound Re-Recording Mixer |
| Sound | John A. Larsen | Supervising Sound Editor |
| Art | Brentan Harron | Assistant Art Director |
| Art | Ignacio McBurney | Assistant Set Decoration |
| Camera | Jimmy E. Jensen | First Assistant "A" Camera |
| Crew | Andy Bishop | Cableman |
| Sound | Jim Brookshire | Dialogue Editor |
| Sound | Donald Sylvester | ADR Supervisor |
| Sound | Amanda Goodpaster | Music Editor |
| Art | Ron Sowden | Assistant Set Decoration |
| Camera | Kerry Hayes | Still Photographer |
| Editing | Gary Burritt | Negative Cutter |
| Editing | Jim Passon | Color Timer |
| Art | Aimee Rousey | Art Department Coordinator |
| Costume & Make-Up | Janice Swayze | Costume Coordinator |
| Production | Stewart Bethune | Unit Production Manager |
| Camera | Tim Merkel | "B" Camera Operator |
| Sound | Laura Graham | ADR Editor |
| Art | Catherine Leighton | Assistant Property Master |
| Costume & Make-Up | Cathy Crandall | Assistant Costume Designer |
| Directing | Gerrod Shully | Second Second Assistant Director |
| Camera | Doane Gregory | Still Photographer |
| Sound | Jon Lavender | Boom Operator |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Crew | Rob Fournier | Armorer |
| Camera | Steve Smith | Key Grip |
| Sound | Doug Hemphill | Sound Re-Recording Mixer |
| Directing | Silver Butler | Third Assistant Director |
| Art | Jimmy Chow | Property Master |
| Sound | John Morris | Foley Supervisor |
| Editing | Chris Regan | Color Timer |
| Editing | Elliot Graham | Editor |
| Art | Elizabeth Wilcox | Set Decoration |
| Art | Guy Hendrix Dyas | Production Design |
| Production | Lauren Shuler Donner | Producer |
| Costume & Make-Up | Louise Mingenbach | Costume Design |
| Camera | Newton Thomas Sigel | Director of Photography |
| Art | Helen Jarvis | Art Direction |
| Production | Ralph Winter | Producer |
| Editing | John Ottman | Editor |
| Crew | Dane Farwell | Stunts |
| Production | Roger Mussenden | Casting |
| Visual Effects | Angie Jones | Animation |
| Visual Effects | Andy Asperin | Animation |
| Crew | Lauro David Chartrand-DelValle | Stunts |
| Crew | James Bamford | Stunts |
| Crew | J.J. Makaro | Stunts |
| Crew | Doug Chapman | Stunts |
| Sound | Michael Herbick | Sound Mixer |
| Art | Geoff Hubbard | Supervising Art Director |
| Crew | Jeffrey Cassidy | Video Assist Operator |
| Production | Kevin Feige | Co-Producer |
| Directing | Christine Wilson | Script Supervisor |
| Visual Effects | Andrew Tamandl | VFX Artist |
| Sound | John Ottman | Original Music Composer |
| Art | Rick Newsome | Storyboard Designer |
| Crew | Melissa R. Stubbs | Stunt Coordinator |
| Crew | Rick Pearce | Stunts |
| Crew | Marny Eng | Stunt Double |
| Production | David Gorder | Associate Producer |
| Production | John H. Radulovic | Line Producer |
| Production | Avi Arad | Executive Producer |
| Production | Tom DeSanto | Executive Producer |
| Production | Stan Lee | Executive Producer |
| Production | Selwyn Roberts | Line Producer |
| Production | Ross T. Fanger | Co-Producer |
| Production | Bryan Singer | Executive Producer |
| Directing | Brian Smrz | Second Unit Director |
| Visual Effects | Ray McIntyre Jr. | Visual Effects Supervisor |
| Art | Melanie Cassidy | Art Department Assistant |
| Visual Effects | Stephen Rosenbaum | Visual Effects Supervisor |
| Sound | Natalie Leggett | Musician |
| Crew | Angela Uyeda | Stunts |
| Art | Angelina Padron | Art Department Coordinator |
| Visual Effects | Gregory Galliani | Visual Effects Supervisor |
| Visual Effects | Paul Taglianetti | Visual Effects Supervisor |
| Costume & Make-Up | Cathy Darby | Costumer |
| Visual Effects | Scott Dougherty | Visual Effects Supervisor |
| Sound | William Stein | Recording Supervision |
| Crew | Gillian Richards | Scenic Artist |
| Camera | Charles Crivier | Dolly Grip |
| Directing | Sallie Hard | Second Assistant Director |
