Een bijzondere ontmoeting met een mysterieuze vreemdeling, levert Pee-Wee een uitnodiging voor een verjaardagsfeestje op. Hiervoor moet hij echter wel zijn veilige thuishaven Fairville verlaten en naar New York reizen.
Ja! de film Pee-wee's Big Holiday is nu beschikbaar om te kijken op Netflix in Nederland.
| Directing | John Lee | Director |
| Writing | Paul Reubens | Writer |
| Writing | Paul Rust | Writer |
| Sound | Mark Mothersbaugh | Original Music Composer |
| Production | Victoria Thomas | Casting |
| Editing | Jeff Buchanan | Editor |
| Camera | Tim Orr | Director of Photography |
| Art | Dan Butts | Production Design |
| Costume & Make-Up | Karen Patch | Costume Design |
| Art | Jennifer Lukehart | Set Decoration |
| Art | Lindsey Moran | Art Direction |
| Production | Paul Reubens | Producer |
| Production | Judd Apatow | Producer |
| Production | Ted Sarandos | Executive Producer |
| Production | Josh Church | Executive Producer |
| Production | Richard Vane | Executive Producer |
| Sound | Michael Turner | Music Supervisor |
| Directing | Diane Weiss | Script Supervisor |
| Sound | George H. Anderson | Supervising Sound Editor |
| Sound | Greg Orloff | Sound Re-Recording Mixer |
| Sound | Tateum Kohut | Sound Re-Recording Mixer |
| Sound | Luis Galdames | Sound Effects Editor |
| Sound | Joe Schiff | Dialogue Editor |
| Sound | Larry Kemp | Dialogue Editor |
| Sound | Agamemnon Andrianos | Sound Mixer |
| Sound | Andy Malcolm | Foley Artist |
| Sound | Sandra Fox | Foley Artist |
| Sound | Goro Koyama | Foley Artist |
| Sound | Jack Heeren | Foley Mixer |
| Sound | Judah Getz | ADR Mixer |
| Production | Ranjani Brow | ADR Voice Casting |
| Production | Ashley Lambert | ADR Voice Casting |
| Production | Andrew Hadzopoulos | Casting Associate |
| Costume & Make-Up | Charlene Amateau | Costume Supervisor |
| Art | Greg Finnin | Property Master |
| Costume & Make-Up | Ve Neill | Makeup Department Head |
| Costume & Make-Up | Kim Santantonio | Hair Department Head |
| Production | Rick Osako | Unit Production Manager |
| Production | Paul Rust | Co-Producer |
| Crew | Mark Rayner | Stunt Coordinator |
| Camera | Matthew A. Petrosky | Steadicam Operator |
| Camera | Matthew A. Petrosky | "A" Camera Operator |
| Camera | Glen Wilson | Still Photographer |
| Production | Chris Bustard | Extras Casting |
| Costume & Make-Up | Kristen Kopp | Assistant Costume Designer |
| Editing | Peggy Eghbalian | First Assistant Editor |
| Sound | Andrew Dorfman | Supervising Music Editor |
| Crew | Mike Miliotti | Transportation Captain |
| Crew | Russ Tolliver | Transportation Coordinator |
| Production | Laura Altmann | Production Coordinator |
| Editing | Siggy Ferstl | Digital Intermediate Colorist |
| Camera | Kenneth Neil Moore | "B" Camera Operator |
| Sound | Brandon Loulias | Boom Operator |
