Agent Charlie leeft een voorbeeldig leven. Als State Trooper probeert hij de vrede binnen de gemeenschap te bewaren. Wat er ook rondom hem gebeurt, hij verheft nooit zijn stem. Kortom, hij is eigenlijk veel te goed voor deze wereld. Ook wanneer zijn vrouw hem op een dag brutaal verlaat, geeft Charlie geen krimp. Maar op een dag gebeurt er iets vreemds met hem. Plots lijdt hij aan een gespleten persoonlijkheid.
Nee, helaas is Me, Myself & Irene nog niet beschikbaar op Netflix in Nederland.
| Directing | Peter Farrelly | Director |
| Directing | Bobby Farrelly | Director |
| Production | Bobby Farrelly | Producer |
| Production | Peter Farrelly | Producer |
| Production | Bradley Thomas | Producer |
| Writing | Peter Farrelly | Screenplay |
| Writing | Bobby Farrelly | Screenplay |
| Writing | Mike Cerrone | Screenplay |
| Sound | Lee Scott | Original Music Composer |
| Camera | Mark Irwin | Director of Photography |
| Editing | Christopher Greenbury | Editor |
| Production | Rick Montgomery | Casting |
| Costume & Make-Up | Pamela Withers | Costume Design |
| Production | Mark Charpentier | Co-Producer |
| Production | Linda Fields | Associate Producer |
| Production | Marc S. Fischer | Co-Producer |
| Production | Clemens E. Franek | Associate Producer |
| Production | Patrick Healy | Associate Producer |
| Production | J.B. Rogers | Co-Producer |
| Production | Tom Schulman | Executive Producer |
| Production | Charles B. Wessler | Executive Producer |
| Sound | Pete Yorn | Original Music Composer |
| Production | Kris Meyer | Associate Producer |
| Art | Sydney J. Bartholomew Jr. | Production Design |
| Art | Arlan Jay Vetter | Art Direction |
| Art | Scott Jacobson | Set Decoration |
| Art | Manya Cetlin | Art Department Coordinator |
| Art | Michael Budge | Assistant Art Director |
| Art | Michael Metzel | Construction Coordinator |
| Art | Christopher J. Noonan | Construction Foreman |
| Art | Robert Kopp | Greensman |
| Art | Seth Blackman | Location Scout |
| Art | Richard Fojo | Set Designer |
| Camera | Eric J. Goldstein | Additional Photography |
| Camera | Stan McClain | Camera Operator |
| Camera | Jeffrey N. Civa | First Assistant Camera |
| Camera | Bubba Sheffield | Key Grip |
| Camera | John S. Moyer | Steadicam Operator |
| Camera | Glenn Watson | Still Photographer |
| Camera | Michael Ferris | Underwater Camera |
| Costume & Make-Up | Virginia Burton | Costume Supervisor |
| Costume & Make-Up | Janice Alexander | Hairstylist |
| Costume & Make-Up | Ardis Cohen | Key Hair Stylist |
| Costume & Make-Up | Bernadette Mazur | Makeup Artist |
| Costume & Make-Up | Clinton Wayne | Prosthetic Makeup Artist |
| Costume & Make-Up | Ann Powderly | Seamstress |
| Costume & Make-Up | Jennifer Dozier | Set Costumer |
| Costume & Make-Up | William Bonn | Set Dressing Artist |
| Crew | Jim Beinke | Animatronic and Prosthetic Effects |
| Crew | Jonathan Askew | Carpenter |
| Crew | Patrice Courtaut | Chef |
| Crew | Marc H. Katz | Craft Service |
| Crew | Denise Avallon | Driver |
| Crew | William Olofsson | Loader |
| Crew | Steven Butcher | Picture Car Coordinator |
| Crew | P. Todd Coe | Post Production Supervisor |
| Crew | Dan Carter | Projection |
| Crew | Stephen DeBoer | Propmaker |
| Art | Richard K. Wright | Property Master |
| Crew | Rand Angelicola | Scenic Artist |
| Crew | Dotan Bonen | Security |
| Crew | Kenneth D. Fitzgibbon | Set Medic |
| Crew | James 'Sporty' Ahern | Set Production Assistant |
| Sound | Andrea Eliseyan | Sound Recordist |
| Crew | Robert Vazquez | Special Effects Coordinator |
| Crew | Nichole Hiltz | Stand In |
| Crew | Rick Barker | Stunt Coordinator |
| Crew | Robert Martini | Transportation Captain |
| Crew | James P. Whalen | Transportation Coordinator |
| Production | Garrett Grant | Unit Production Manager |
| Crew | Ernie Malik | Unit Publicist |
| Directing | Hal Olofsson | Assistant Director |
| Editing | Dennis McNeill | Color Timer |
| Editing | Sean Madaras | Editorial Production Assistant |
| Editing | Larry Madaras | First Assistant Editor |
| Lighting | Troy White | Best Boy Electric |
| Lighting | Troy White | Best Boy Electric |
| Lighting | Samantha Bahramian | Electrician |
| Lighting | Jay W. Yowler | Gaffer |
| Lighting | Lon Caracappa | Rigging Gaffer |
| Lighting | Jenn Mears | Rigging Grip |
| Production | Michael G. Miller | Casting Associate |
| Production | Thomas A. Imperato | Executive In Charge Of Production |
| Production | Eric Hedayat | Location Manager |
| Production | Harvey Malkin | Production Accountant |
| Production | Melissa Stanley Cohen | Production Coordinator |
| Sound | Jon Udell | Boom Operator |
| Sound | Douglas Hinton | Assistant Sound Editor |
| Sound | Dawn Fintor | Foley |
| Sound | Brian Bulman | Music Editor |
| Sound | Manish Raval | Music Supervisor |
| Sound | Andy Kopetzky | Sound Editor |
| Sound | Ted Caplan | Sound Effects Editor |
| Sound | Jonathon 'Earl' Stein | Sound Mixer |
| Sound | Vanessa Lapato | Supervising Sound Editor |
| Visual Effects | Allison Troxell | Visual Effects Producer |
| Visual Effects | Constance Bracewell | Visual Effects Supervisor |
| Crew | Walt Vincent | Score Engineer |
| Crew | Michael Cassidy | Stunts |
| Costume & Make-Up | Felice Diamond | Assistant Makeup Artist |
| Costume & Make-Up | Denverly Grant | Key Set Costumer |
| Costume & Make-Up | Tony Gardner | Makeup Effects Designer |
| Directing | Greg Guzik | Additional Second Assistant Director |
| Directing | Ingrid K. Behrens | Second Second Assistant Director |
| Directing | Josh Klausner | Second Unit Director |
| Art | Lorne Grant | Assistant Property Master |
| Art | Chelsea Heneise | Title Designer |
| Sound | Derek Casari | ADR Engineer |
| Sound | Charleen Richards-Steeves | ADR Mixer |
| Sound | David Lucarelli | ADR Recordist |
| Sound | Steve F. Price | First Assistant Sound Editor |
| Sound | Dawn Fintor | Foley Artist |
| Sound | David Betancourt | Foley Mixer |
| Sound | Skip Longfellow | Sound Assistant |
| Crew | Brandon Trost | Special Effects Assistant |
| Crew | Andrew Campbell | Special Effects Technician |
| Crew | Pat Banta | Stunt Double |
| Camera | James J. Callahan | Best Boy Grip |
| Camera | Matt Irwin | Camera Trainee |
| Camera | Jerry Bertolami | Dolly Grip |
| Camera | Egor Davidoff | Second Assistant Camera |
| Visual Effects | Jamie Dixon | Lead Animator |
| Editing | Gary Burritt | Negative Cutter |
| Production | Pam Jack | Assistant Location Manager |
| Production | Karen Preus | Location Assistant |
| Production | Kori Shadrick | Location Coordinator |
| Sound | Lee Scott | Supervising Music Editor |
| Crew | Susan Humphrey | Animal Wrangler |
| Production | Samantha Bass | Art Department Production Assistant |
| Production | Nadia Randazzo Bombino | Assistant Accountant |
| Production | Dianne Bellino | Assistant Production Coordinator |
| Production | Kevin Fennessy | Extras Casting |
| Production | Maria Celeste Arruda III | Extras Casting Assistant |
| Production | Denise Rosen | First Assistant Accountant |
| Production | Angela Randazzo | Payroll Accountant |
| Production | Jennifer Battista | Production Assistant |
| Production | Ann Christman | Production Secretary |
| Production | Michael DeSantis | Second Assistant Accountant |
| Production | Liza-Anne Cabral | Travel Coordinator |
| Crew | John-Clay Scott | Stunts |
| Crew | Patricia M. Peters | Stunts |
| Crew | Kurt Beckler | Assistant Craft Service |
| Sound | Alison Fisher | Dialogue Editor |
| Crew | Paul Salamoff | Makeup Effects |
| Crew | Barbara Anne Klein | Stunts |
| Crew | Mark De Alessandro | Stunts |
| Production | Hank Chilton | Production Supervisor |
| Crew | Denney Pierce | Stunts |
| Crew | Gilbert B. Combs | Stunts |
| Crew | Corey Michael Eubanks | Stunts |
| Crew | Joey Box | Stunts |
