Agent Charlie leeft een voorbeeldig leven. Als State Trooper probeert hij de vrede binnen de gemeenschap te bewaren. Wat er ook rondom hem gebeurt, hij verheft nooit zijn stem. Kortom, hij is eigenlijk veel te goed voor deze wereld. Ook wanneer zijn vrouw hem op een dag brutaal verlaat, geeft Charlie geen krimp. Maar op een dag gebeurt er iets vreemds met hem. Plots lijdt hij aan een gespleten persoonlijkheid.
Nee, helaas is Me, Myself & Irene nog niet beschikbaar op Netflix in Nederland.
| Directing | Peter Farrelly | Director |
| Production | Bobby Farrelly | Producer |
| Writing | Mike Cerrone | Screenplay |
| Writing | Peter Farrelly | Screenplay |
| Production | Rick Montgomery | Casting |
| Costume & Make-Up | Pamela Withers | Costume Design |
| Directing | Bobby Farrelly | Director |
| Camera | Mark Irwin | Director of Photography |
| Production | Peter Farrelly | Producer |
| Writing | Bobby Farrelly | Screenplay |
| Editing | Christopher Greenbury | Editor |
| Production | Bradley Thomas | Producer |
| Sound | Lee Scott | Original Music Composer |
| Crew | Paul Salamoff | Makeup Effects |
| Sound | Pete Yorn | Original Music Composer |
| Production | J.B. Rogers | Co-Producer |
| Production | Tom Schulman | Executive Producer |
| Production | Charles B. Wessler | Executive Producer |
| Production | Marc S. Fischer | Co-Producer |
| Production | Linda Fields Hill | Associate Producer |
| Production | Mark Charpentier | Co-Producer |
| Production | Patrick Healy | Associate Producer |
| Crew | Corey Michael Eubanks | Stunts |
| Production | Kris Meyer | Associate Producer |
| Costume & Make-Up | Janice Alexander | Hairstylist |
| Crew | Kenneth D. Fitzgibbon | Set Medic |
| Crew | Rand Angelicola | Scenic Artist |
| Crew | Robert Vazquez | Special Effects Coordinator |
| Crew | Denise Avallon | Driver |
| Art | Seth Blackman | Location Scout |
| Costume & Make-Up | Clinton Wayne | Prosthetic Makeup Artist |
| Crew | Jonathan Askew | Carpenter |
| Crew | Robert Martini | Transportation Captain |
| Art | Sydney J. Bartholomew Jr. | Production Design |
| Camera | Glenn Watson | Still Photographer |
| Costume & Make-Up | Ann Powderly | Seamstress |
| Crew | Stephen DeBoer | Propmaker |
| Production | Garrett Grant | Unit Production Manager |
| Costume & Make-Up | Virginia Burton | Costume Supervisor |
| Art | Christopher J. Noonan | Construction Foreman |
| Crew | Dotan Bonen | Security |
| Editing | Larry Madaras | First Assistant Editor |
| Sound | Andy Kopetzky | Sound Editor |
| Art | Robert Kopp | Greensman |
| Art | Richard Fojo | Set Designer |
| Crew | Patrice Courtaut | Chef |
| Crew | William Olofsson | Loader |
| Crew | Rick Barker | Stunt Coordinator |
| Crew | James P. Whalen Jr. | Transportation Coordinator |
| Art | Richard K. Wright | Property Master |
| Crew | James 'Sporty' Ahern | Set Production Assistant |
| Sound | Andrea Eliseyan | Sound Recordist |
| Camera | Stan McClain | Camera Operator |
| Camera | Jeffrey N. Civa | First Assistant Camera |
| Art | Manya Cetlin | Art Department Coordinator |
| Art | Michael Budge | Assistant Art Director |
| Art | Michael Metzel | Construction Coordinator |
| Crew | Jim Beinke | Animatronic and Prosthetic Effects |
| Crew | Steven Butcher | Picture Car Coordinator |
| Crew | Nichole Hiltz | Stand In |
| Camera | Bubba Sheffield | Key Grip |
| Art | Arlan Jay Vetter | Art Direction |
| Art | Scott Jacobson | Set Decoration |
| Costume & Make-Up | Ardis Cohen | Key Hair Stylist |
| Costume & Make-Up | William Bonn | Set Dressing Artist |
| Crew | Marc H. Katz | Craft Service |
| Production | Thomas A. Imperato | Executive In Charge Of Production |
| Lighting | Jenn Mears | Rigging Grip |
| Production | Michael G. Miller | Casting Associate |
| Sound | Jonathon 'Earl' Stein | Sound Mixer |
| Production | Eric Hedayat | Location Manager |
| Sound | Dawn Fintor | Foley |
| Editing | Sean Madaras | Editorial Production Assistant |
| Sound | Jon Udell | Boom Operator |
| Sound | Vanessa Lapato | Supervising Sound Editor |
| Camera | Eric J. Goldstein | Additional Photography |
| Camera | John S. Moyer | Steadicam Operator |
| Costume & Make-Up | Bernadette Mazur | Makeup Artist |
| Costume & Make-Up | Jennifer Dozier | Set Costumer |
| Crew | Walt Vincent | Score Engineer |
| Lighting | Lon Caracappa | Rigging Gaffer |
| Crew | Ernie Malik | Unit Publicist |
| Sound | Douglas Hinton | Assistant Sound Editor |
| Sound | Brian Bulman | Music Editor |
| Lighting | Troy White | Best Boy Electric |
| Visual Effects | Allison Troxell | Visual Effects Producer |
| Directing | Hal Olofsson | Assistant Director |
| Camera | Michael Ferris | Underwater Camera |
| Crew | P. Todd Coe | Post Production Supervisor |
| Crew | Dan Carter | Projection |
| Editing | Dennis McNeill | Color Timer |
| Lighting | Samantha Bahramian | Electrician |
| Lighting | Jay W. Yowler | Gaffer |
| Lighting | Troy White | Best Boy Electric |
| Sound | Manish Raval | Music Supervisor |
| Production | Harvey Malkin | Production Accountant |
| Production | Melissa 'Stanley' Cohen | Production Coordinator |
| Sound | Ted Caplan | Sound Effects Editor |
| Visual Effects | Constance Bracewell | Visual Effects Supervisor |
| Crew | Joey Box | Stunts |
| Crew | Barbara Anne Klein | Stunts |
| Crew | Mark De Alessandro | Stunts |
| Production | Hank Chilton | Production Supervisor |
| Crew | Denney Pierce | Stunts |
| Crew | Gilbert B. Combs | Stunts |
| Crew | Michael Cassidy | Stunts |
| Editing | Gary Burritt | Negative Cutter |
| Production | Karen Preus | Location Assistant |
| Sound | Lee Scott | Supervising Music Editor |
| Directing | Greg Guzik | Additional Second Assistant Director |
| Sound | Skip Longfellow | Sound Assistant |
| Production | Dianne Bellino | Assistant Production Coordinator |
| Production | Liza-Anne Cabral | Travel Coordinator |
| Sound | David Lucarelli | ADR Recordist |
| Production | Kevin Fennessy | Extras Casting |
| Production | Angela Randazzo | Payroll Accountant |
| Camera | Jerry Bertolami | Dolly Grip |
| Production | Maria Celeste Arruda III | Extras Casting Assistant |
| Crew | Brandon Trost | Special Effects Assistant |
| Production | Michael DeSantis | Second Assistant Accountant |
| Sound | Dawn Fintor | Foley Artist |
| Production | Pam Jack | Assistant Location Manager |
| Production | Kori Shadrick | Location Coordinator |
| Crew | Susan Humphrey | Animal Wrangler |
| Production | Denise Rosen | First Assistant Accountant |
| Costume & Make-Up | Denverly Grant | Key Set Costumer |
| Sound | Steve F. Price | First Assistant Sound Editor |
| Crew | Andrew Campbell | Special Effects Technician |
| Camera | James J. Callahan | Best Boy Grip |
| Production | Jennifer Battista | Production Assistant |
| Art | Lorne Grant | Assistant Property Master |
| Sound | Charleen Richards-Steeves | ADR Mixer |
| Production | Samantha Bass | Art Department Production Assistant |
| Production | Ann Christman | Production Secretary |
| Crew | Pat Banta | Stunt Double |
| Visual Effects | Jamie Dixon | Lead Animator |
| Costume & Make-Up | Tony Gardner | Makeup Effects Designer |
| Directing | Ingrid K. Behrens | Second Second Assistant Director |
| Art | Chelsea Heneise | Title Designer |
| Sound | David Betancourt | Foley Mixer |
| Costume & Make-Up | Felice Diamond | Assistant Makeup Artist |
| Sound | Derek Casari | ADR Engineer |
| Camera | Matt Irwin | Camera Trainee |
| Camera | Egor Davidoff | Second Assistant Camera |
| Production | Nadia Randazzo Bombino | Assistant Accountant |
| Directing | Josh Klausner | Second Unit Director |
| Crew | John-Clay Scott | Stunts |
| Crew | Patricia M. Peters | Stunts |
| Crew | Kurt Beckler | Assistant Craft Service |
| Sound | Alison Fisher | Dialogue Editor |
| Crew | Phil Culotta | Stunts |
| Crew | Clint Lilley | Stunts |
| Production | Clem Franek | Associate Producer |
