Carl en Molly Peterson zijn een pas getrouwd stelletje met een nieuw leven, nieuw huisje en pril geluk. Wanneer echter Carl's beste vriend Randy Dupree ontslagen wordt en in de goot belandt, nodigt Carl hem uit een tijdje bij hen te komen wonen. Dupree heeft het echter iets te goed naar zijn zin en Carl heeft het al moeilijk genoeg om de verantwoordelijke echtgenoot uit te hangen. Dan blijkt Dupree ook nog eens veel te goede maatjes te worden met Molly en haar vader..
Nee, helaas is You, Me and Dupree nog niet beschikbaar op Netflix in Nederland.
| Production | Owen Wilson | Producer |
| Editing | Debra Neil-Fisher | Editor |
| Writing | Michael LeSieur | Screenplay |
| Directing | Anthony Russo | Director |
| Directing | Joe Russo | Director |
| Camera | Charles Minsky | Director of Photography |
| Editing | Peter B. Ellis | Editor |
| Production | Aaron Kaplan | Executive Producer |
| Production | Scott Stuber | Producer |
| Production | Michael Fottrell | Executive Producer |
| Art | Barry Robison | Production Design |
| Costume & Make-Up | Karen Patch | Costume Design |
| Art | Barbara Munch | Set Decoration |
| Production | Sean Perrone | Executive Producer |
| Sound | Theodore Shapiro | Original Music Composer |
| Production | Deborah Aquila | Casting |
| Costume & Make-Up | Hasmig Karaciosian | Seamstress |
| Art | Libby Morris | Set Decoration Buyer |
| Costume & Make-Up | Medusah | Hair Department Head |
| Costume & Make-Up | Denise Dellavalle | Key Makeup Artist |
| Art | Bob Skemp | Greensman |
| Costume & Make-Up | Vickie Mynes | Key Hair Stylist |
| Art | Paul Detlefson | Set Dresser |
| Costume & Make-Up | Elaine Perlmann | Assistant Costume Designer |
| Costume & Make-Up | Kimberly Greene | Makeup Department Head |
| Art | Josh Lusby | Set Designer |
| Art | Patricio M. Farrell | Assistant Art Director |
| Art | Chris Samp | Standby Painter |
| Costume & Make-Up | Paula Hong | Hairstylist |
| Directing | Jennifer Carno | Script Coordinator |
| Art | Joey Genitempo | Set Painter |
| Lighting | Ronald R. Koch Jr. | Lighting Technician |
| Art | Fermin Davalos | Location Scout |
| Sound | George Doering | Musician |
| Crew | Lesley Aletter | Utility Stunts |
| Camera | Brian T. Pitts | Additional Camera |
| Art | Rodolfo Damaggio | Production Illustrator |
| Sound | Shawn Murphy | Scoring Mixer |
| Crew | Cliff Fleming | Aerial Coordinator |
| Sound | Bob Beher | Foley Supervisor |
| Production | Catherine S. McComb | Production Supervisor |
| Production | Michael Fottrell | Unit Production Manager |
| Directing | Liliana M. Molina | Script Supervisor |
| Editing | Ryan Helsley | Digital Intermediate |
| Sound | Randall Poster | Music Supervisor |
| Camera | Louie DeMarco | First Assistant "B" Camera |
| Art | Jason Sweers | Graphic Designer |
| Sound | Philip Rogers | ADR Recordist |
| Production | Curtis Collins | Location Manager |
| Camera | Tommy Klines | First Assistant "A" Camera |
| Camera | Marcos O. Lopez | Second Assistant Camera |
| Crew | Anthony Woods | Set Medic |
| Sound | Jack Snyder | Sound Recordist |
| Crew | Maxine Abarbara | Studio Teacher |
| Costume & Make-Up | Amy Jo Hoppenfeld | Key Costumer |
| Costume & Make-Up | Dominic Gherardi | Tailor |
| Crew | Fred Teague | Transportation Captain |
| Production | Carlo Pratto | Post Production Accountant |
| Editing | Sam Seig | First Assistant Editor |
| Costume & Make-Up | Josh Ian Elliott | On Set Dresser |
| Camera | Landon Ruddel | Best Boy Grip |
| Lighting | Steve Reinhardt | Assistant Chief Lighting Technician |
| Production | Kirby Adams | First Assistant Accountant |
| Visual Effects | Chris Ryan | CG Artist |
| Lighting | Jose F. Barrios | Rigging Grip |
| Sound | Benjamin Beardwood | Dialogue Editor |
| Crew | Marco Baccicalupi | Driver |
| Art | Greg Sanger | Leadman |
| Production | Donna Glasser-Hancock | Production Accountant |
| Art | Lance Ashton Slaton | Storyboard Artist |
| Camera | Michael C. Price | Key Grip |
| Art | Carolyn Lassek | Assistant Property Master |
| Art | Douglas J. Stewart | Textile Artist |
| Sound | David Betancourt | Foley Recordist |
| Sound | Andrew Silver | Music Editor |
| Camera | David E. Diano | "B" Camera Operator |
| Crew | Steve Burnes | Propmaker |
| Crew | Victor Lozano | Marine Coordinator |
| Visual Effects | Andrew Tucker | 3D Artist |
| Directing | Bob Roe | First Assistant Director |
| Lighting | James Keys | Rigging Gaffer |
| Visual Effects | Fumi Mashimo | Animation Supervisor |
| Art | Bruce DiValerio | Construction Coordinator |
| Editing | Michael Eaves | Digital Color Timer |
| Crew | Ron Bolanowski | Special Effects Coordinator |
| Production | Jennifer L. Smith | Casting Associate |
| Sound | Andrew Spencer Dawson | Sound Editor |
| Crew | Jason Leib | Post Production Supervisor |
| Art | Palma Bellardoni | Art Department Coordinator |
| Sound | Thom Brennan | Foley Editor |
| Production | Patti Hawn | Publicist |
| Visual Effects | Collin Fowler | Visual Effects Coordinator |
| Sound | Roy Seeger | First Assistant Sound Editor |
| Sound | Carl Fischer | Boom Operator |
| Camera | Mario Cisneros | Grip |
| Crew | Jimmy N. Roberts | Stunt Coordinator |
| Crew | Ken Sale | Transportation Co-Captain |
| Crew | Valerie Johnson | Set Production Assistant |
| Costume & Make-Up | Hilary Niederer | Costumer |
| Visual Effects | Melissa Brockman | Visual Effects Producer |
| Costume & Make-Up | Lisa D. Quercioli | Set Costumer |
| Visual Effects | Thad Beier | Visual Effects Supervisor |
| Editing | Sean Thompson | Additional Editor |
| Costume & Make-Up | Charlene Amateau | Costume Supervisor |
| Sound | Tony Blondal | Orchestrator |
| Lighting | Danny Ault | Electrician |
| Sound | Andrea Horta | ADR Editor |
| Camera | Scott Whitbread | Second Assistant "B" Camera |
| Crew | Michael Rayle | Cableman |
| Crew | Jim Dunbar | Thanks |
| Camera | Melissa Moseley | Still Photographer |
| Crew | Robert Castro | Stand In |
| Camera | P. Scott Sakamoto | Camera Operator |
| Sound | Jeff Gomillion | ADR Mixer |
| Crew | Dayne Ahuna | Craft Service |
| Sound | Bruce Tanis | Sound Effects Editor |
| Lighting | Michelle LeDoux | Best Boy Electric |
| Camera | Sal Alvarez | Camera Loader |
| Camera | Dale White | Second Assistant "A" Camera |
| Art | Tommy Tomlinson | Property Master |
| Crew | Jesse Olivares | Video Assist Operator |
| Directing | Adam Davidson | Second Unit Director |
| Sound | Dawn Fintor | Foley Artist |
| Crew | John A. Brubaker | Transportation Coordinator |
| Sound | Petur Hliddal | Sound Mixer |
| Art | Catherine Leyba | Set Decorating Coordinator |
| Camera | Eric Budlong | Dolly Grip |
| Production | Erin Toner | Casting Assistant |
| Sound | Bruce Babcock | Conductor |
| Lighting | Jeff Murrell | Chief Lighting Technician |
| Production | Amy Denning Winfrey | Payroll Accountant |
| Production | Mark Kurzweil | Second Assistant Accountant |
| Editing | Mark Sachen | Colorist |
| Crew | James A. Lundin | Base Camp Operator |
| Production | Tammy L. Smith | Extras Casting |
| Production | Alexandra Ward | Art Department Production Assistant |
| Editing | Mary Beth Smith | Negative Cutter |
| Production | Michele LaBrucherie | Key Set Production Assistant |
| Production | Caitlin McKenna | ADR Voice Casting |
| Sound | Stephen Coleman | Music Programmer |
| Production | Carrie Oyer | Assistant Production Coordinator |
| Production | Adam Courier | Production Assistant |
| Production | Alyssa Evans | Production Coordinator |
| Sound | Steven D. Williams | Supervising Sound Editor |
| Directing | Bernie Bonner Axelrod | Second Second Assistant Director |
| Art | Paul Sonski | Art Direction |
| Art | Kevin Constant | Supervising Art Director |
| Production | Mary Parent | Producer |
| Art | David Christopher Campbell | Construction Foreman |
| Crew | Erik Rondell | Stunts |
| Crew | Tanoai Reed | Stunts |
| Crew | Dick Ziker | Stunts |
| Production | Tricia Wood | Casting |
| Art | Dean Wolcott | Set Designer |
| Crew | Helena Barrett | Stunts |
| Costume & Make-Up | Valli O'Reilly | Makeup Artist |
| Costume & Make-Up | Kathryn Blondell | Hairstylist |
| Costume & Make-Up | Leslie Fuller | Makeup Artist |
