Carl en Molly Peterson zijn een pas getrouwd stelletje met een nieuw leven, nieuw huisje en pril geluk. Wanneer echter Carl's beste vriend Randy Dupree ontslagen wordt en in de goot belandt, nodigt Carl hem uit een tijdje bij hen te komen wonen. Dupree heeft het echter iets te goed naar zijn zin en Carl heeft het al moeilijk genoeg om de verantwoordelijke echtgenoot uit te hangen. Dan blijkt Dupree ook nog eens veel te goede maatjes te worden met Molly en haar vader..
Nee, helaas is You, Me and Dupree nog niet beschikbaar op Netflix in Nederland.
| Costume & Make-Up | Karen Patch | Costume Design |
| Production | Sean Perrone | Executive Producer |
| Production | Scott Stuber | Producer |
| Art | Barbara Munch | Set Decoration |
| Directing | Anthony Russo | Director |
| Art | Barry Robison | Production Design |
| Sound | Theodore Shapiro | Original Music Composer |
| Editing | Debra Neil-Fisher | Editor |
| Directing | Joe Russo | Director |
| Production | Deborah Aquila | Casting |
| Production | Aaron Kaplan | Executive Producer |
| Production | Michael Fottrell | Executive Producer |
| Production | Owen Wilson | Producer |
| Editing | Peter B. Ellis | Editor |
| Writing | Michael LeSieur | Screenplay |
| Camera | Charles Minsky | Director of Photography |
| Production | Tricia Wood | Casting |
| Production | Mary Parent | Producer |
| Art | Kevin Constant | Supervising Art Director |
| Art | Paul Sonski | Art Direction |
| Costume & Make-Up | Elaine Perlmann | Assistant Costume Designer |
| Costume & Make-Up | Medusah | Hair Department Head |
| Costume & Make-Up | Paula Hong | Hairstylist |
| Costume & Make-Up | Denise Dellavalle | Key Makeup Artist |
| Costume & Make-Up | Kimberly Greene | Makeup Department Head |
| Costume & Make-Up | Hasmig Karaciosian | Seamstress |
| Directing | Jennifer Carno | Script Coordinator |
| Art | Patricio M. Farrell | Assistant Art Director |
| Art | Bob Skemp | Greensman |
| Costume & Make-Up | Vickie Mynes | Key Hair Stylist |
| Art | Joey Genitempo | Set Painter |
| Art | Libby Morris | Set Decoration Buyer |
| Art | Josh Lusby | Set Designer |
| Art | Paul Detlefson | Set Dresser |
| Art | Chris Samp | Standby Painter |
| Sound | Roy Seeger | First Assistant Sound Editor |
| Sound | Carl Fischer | Boom Operator |
| Sound | Benjamin Beardwood | Dialogue Editor |
| Sound | Bob Beher | Foley Supervisor |
| Sound | Thom Brennan | Foley Editor |
| Sound | Shawn Murphy | Scoring Mixer |
| Sound | Andrew Spencer Dawson | Sound Editor |
| Crew | Jason Leib | Post Production Supervisor |
| Production | Catherine S. McComb | Production Supervisor |
| Production | Michael Fottrell | Unit Production Manager |
| Crew | Ron Bolanowski | Special Effects Coordinator |
| Visual Effects | Andrew Tucker | 3D Artist |
| Directing | Bob Roe | First Assistant Director |
| Directing | Liliana M. Molina | Script Supervisor |
| Crew | Jimmy N. Roberts | Stunt Coordinator |
| Crew | Lesley Aletter | Utility Stunts |
| Camera | Brian T. Pitts | Additional Camera |
| Crew | Cliff Fleming | Aerial Coordinator |
| Art | Palma Bellardoni | Art Department Coordinator |
| Camera | Mario Cisneros | Grip |
| Lighting | Ronald R. Koch Jr. | Lighting Technician |
| Lighting | James Keys | Rigging Gaffer |
| Lighting | Jose F. Barrios | Rigging Grip |
| Visual Effects | Fumi Mashimo | Animation Supervisor |
| Production | Jennifer L. Smith | Casting Associate |
| Art | Bruce DiValerio | Construction Coordinator |
| Editing | Michael Eaves | Digital Color Timer |
| Editing | Ryan Helsley | Digital Intermediate |
| Art | Fermin Davalos | Location Scout |
| Art | Rodolfo Damaggio | Production Illustrator |
| Sound | George Doering | Musician |
| Crew | Marco Baccicalupi | Driver |
| Crew | Fred Teague | Transportation Captain |
| Crew | Ken Sale | Transportation Co-Captain |
| Art | Greg Sanger | Leadman |
| Production | Alyssa Evans | Production Coordinator |
| Crew | Michael Rayle | Cableman |
| Art | Tommy Tomlinson | Property Master |
| Crew | Steve Burnes | Propmaker |
| Crew | Dayne Ahuna | Craft Service |
| Crew | Victor Lozano | Marine Coordinator |
| Crew | Anthony Woods | Set Medic |
| Production | Carlo Pratto | Post Production Accountant |
| Production | Donna Glasser-Hancock | Production Accountant |
| Production | Patti Hawn | Publicist |
| Crew | Valerie Johnson | Set Production Assistant |
| Sound | Bruce Tanis | Sound Effects Editor |
| Sound | Petur Hliddal | Sound Mixer |
| Sound | Jack Snyder | Sound Recordist |
| Crew | Robert Castro | Stand In |
| Art | Lance Ashton Slaton | Storyboard Artist |
| Crew | Maxine Abarbara | Studio Teacher |
| Sound | Steven D. Williams | Supervising Sound Editor |
| Crew | Jim Dunbar | Thanks |
| Lighting | Michelle LeDoux | Best Boy Electric |
| Camera | Michael C. Price | Key Grip |
| Editing | Sam Seig | First Assistant Editor |
| Sound | Randall Poster | Music Supervisor |
| Camera | Sal Alvarez | Camera Loader |
| Visual Effects | Thad Beier | Visual Effects Supervisor |
| Editing | Sean Thompson | Additional Editor |
| Visual Effects | Collin Fowler | Visual Effects Coordinator |
| Crew | Jesse Olivares | Video Assist Operator |
| Sound | Tony Blondal | Orchestrator |
| Costume & Make-Up | Hilary Niederer | Costumer |
| Costume & Make-Up | Amy Jo Hoppenfeld | Key Costumer |
| Visual Effects | Melissa Brockman | Visual Effects Producer |
| Costume & Make-Up | Josh Ian Elliott | On Set Dresser |
| Costume & Make-Up | Dominic Gherardi | Tailor |
| Directing | Bernie Bonner Axelrod | Second Second Assistant Director |
| Camera | P. Scott Sakamoto | Camera Operator |
| Directing | Adam Davidson | Second Unit Director |
| Lighting | Danny Ault | Electrician |
| Art | Carolyn Lassek | Assistant Property Master |
| Camera | Louie DeMarco | First Assistant "B" Camera |
| Art | Jason Sweers | Graphic Designer |
| Camera | Melissa Moseley | Still Photographer |
| Art | Catherine Leyba | Set Decorating Coordinator |
| Art | Douglas J. Stewart | Textile Artist |
| Sound | Andrea Horta | ADR Editor |
| Sound | Jeff Gomillion | ADR Mixer |
| Sound | Philip Rogers | ADR Recordist |
| Costume & Make-Up | Charlene Amateau | Costume Supervisor |
| Costume & Make-Up | Lisa D. Quercioli | Set Costumer |
| Sound | Dawn Fintor | Foley Artist |
| Sound | David Betancourt | Foley Recordist |
| Production | Curtis Collins | Location Manager |
| Sound | Andrew Silver | Music Editor |
| Camera | David E. Diano | "B" Camera Operator |
| Camera | Landon Ruddel | Best Boy Grip |
| Crew | John A. Brubaker | Transportation Coordinator |
| Camera | Eric Budlong | Dolly Grip |
| Camera | Tommy Klines | First Assistant "A" Camera |
| Camera | Dale White | Second Assistant "A" Camera |
| Camera | Scott Whitbread | Second Assistant "B" Camera |
| Camera | Marcos O. Lopez | Second Assistant Camera |
| Production | Caitlin McKenna | ADR Voice Casting |
| Production | Erin Toner | Casting Assistant |
| Editing | Mark Sachen | Colorist |
| Editing | Mary Beth Smith | Negative Cutter |
| Sound | Bruce Babcock | Conductor |
| Sound | Stephen Coleman | Music Programmer |
| Production | Alexandra Ward | Art Department Production Assistant |
| Production | Kirby Adams | First Assistant Accountant |
| Lighting | Steve Reinhardt | Assistant Chief Lighting Technician |
| Production | Carrie Oyer | Assistant Production Coordinator |
| Crew | James A. Lundin | Base Camp Operator |
| Visual Effects | Chris Ryan | CG Artist |
| Lighting | Jeff Murrell | Chief Lighting Technician |
| Production | Tammy L. Smith | Extras Casting |
| Production | Michele LaBrucherie | Key Set Production Assistant |
| Production | Amy Denning Winfrey | Payroll Accountant |
| Production | Adam Courier | Production Assistant |
| Production | Mark Kurzweil | Second Assistant Accountant |
| Art | David Christopher Campbell | Construction Foreman |
| Crew | Dick Ziker | Stunts |
| Art | Dean Wolcott | Set Designer |
| Crew | Helena Barrett | Stunts |
| Crew | Erik Rondell | Stunts |
| Crew | Tanoai Reed | Stunts |
