1964, een Rooms-Katholieke school in de Bronx. Zuster Aloysius (Meryl Streep) komt in een lastige situatie. Er zijn redenen om priester Flynn (Philip Seymour Hoffman) te verdenken van onzedelijk gedrag. Moet ze de priester, die haar meerdere is, confronteren met deze vermoedens?
| Camera | Roger Deakins | Director of Photography |
| Editing | Dylan Tichenor | Editor |
| Production | Scott Rudin | Producer |
| Directing | John Patrick Shanley | Director |
| Crew | Jennifer Lamb | Stunt Double |
| Writing | John Patrick Shanley | Screenplay |
| Writing | John Patrick Shanley | Theatre Play |
| Crew | Michael Queen | Compositors |
| Production | Celia D. Costas | Unit Production Manager |
| Art | David Gropman | Production Design |
| Art | Zoran Blazevic | Location Scout |
| Art | John Spady | Location Scout |
| Crew | Jennifer Lane | Post Production Supervisor |
| Art | Peter Rogness | Art Direction |
| Art | Ellen Christiansen | Set Decoration |
| Production | Deb Dyer | Production Supervisor |
| Production | Nora Skinner | Associate Producer |
| Production | Amelia Rasche McCarthy | Casting Associate |
| Production | Ellen Chenoweth | Casting |
| Production | Celia D. Costas | Executive Producer |
| Production | Mark Roybal | Producer |
| Production | Joe Guest | Location Manager |
| Art | Matthew H. Wiesner | Location Scout |
| Costume & Make-Up | Ann Roth | Costume Design |
| Directing | Dianne Dreyer | Script Supervisor |
| Production | Patty Willett | Production Coordinator |
| Costume & Make-Up | David Davenport | Costume Supervisor |
| Sound | Howard Shore | Original Music Composer |
| Crew | Peter Bucossi | Stunt Coordinator |
| Editing | Michael Hatzer | Digital Intermediate Colorist |
