In de herfst van 1953 trekt de ambitieuze lerares Katherine Watson naar het Wellesley College, één van de meest prestigieuze meisjesscholen van de Verenigde Staten. Ze zal er kunstgeschiedenis gaan doceren. De aanpassing aan haar nieuwe omgeving verloopt echter moeizaam. Haar liefde voor moderne kunst en haar uitgesproken mening over de rol van de vrouw in de samenleving worden allesbehalve gewaardeerd door haar conservatieve collega's.
Ja! de film Mona Lisa Smile is nu beschikbaar om te kijken op Netflix in Nederland.
| Production | Deborah Schindler | Producer |
| Writing | Mark Rosenthal | Screenplay |
| Directing | Mike Newell | Director |
| Production | Paul Schiff | Producer |
| Writing | Lawrence Konner | Screenplay |
| Production | Elaine Goldsmith-Thomas | Producer |
| Production | Joe Roth | Executive Producer |
| Editing | Mick Audsley | Editor |
| Camera | Anastas N. Michos | Director of Photography |
| Sound | Rachel Portman | Original Music Composer |
| Art | Patricia Woodbridge | Art Direction |
| Production | Susie Farris | Casting |
| Production | Ellen Chenoweth | Casting |
| Visual Effects | Randall Balsmeyer | Visual Effects Supervisor |
| Art | Jane Musky | Production Design |
| Costume & Make-Up | Michael Dennison | Costume Design |
| Directing | Lisa Katcher | Script Supervisor |
| Production | Richard Baratta | Co-Producer |
| Art | Chris Nickerson | Set Decoration |
| Costume & Make-Up | Margot Boccia | Makeup Department Head |
| Art | Susan Bode Tyson | Set Decoration |
| Art | Ray Fisher | Leadman |
| Art | Joseph S. Alfieri | Construction Coordinator |
| Costume & Make-Up | Frances Kolar | Key Makeup Artist |
| Directing | Joseph P. Reidy | First Assistant Director |
| Sound | Peter Burgis | Foley Artist |
| Sound | Andie Derrick | Foley Artist |
| Sound | Tim Cavagin | Sound Re-Recording Mixer |
| Sound | Colette D. Dahanne | ADR Mixer |
| Sound | Colin Cooper | ADR Mixer |
| Sound | Peter Gleaves | ADR Mixer |
| Sound | Daniel Laurie | ADR Editor |
| Sound | Derek Trigg | Foley Editor |
| Sound | Steve Single | Sound Re-Recording Mixer |
| Costume & Make-Up | Carla Antonino | Makeup Artist |
| Costume & Make-Up | Kristen Barry | Hairstylist |
| Costume & Make-Up | Robert Chiu | Hairstylist |
| Costume & Make-Up | Bonnie Clevering | Hairstylist |
| Costume & Make-Up | Richard Dean | Makeup Artist |
| Costume & Make-Up | Paula Dion | Hairstylist |
| Costume & Make-Up | Joseph Farulla | Makeup Artist |
| Costume & Make-Up | Donna Marie Fischetto | Hairstylist |
| Costume & Make-Up | Michelle Johnson | Hairstylist |
| Costume & Make-Up | Heidi Kulow | Makeup Artist |
| Costume & Make-Up | Christine Leiter | Makeup Artist |
| Costume & Make-Up | Brenda McNally | Hairstylist |
| Costume & Make-Up | John Quaglia | Hairstylist |
| Costume & Make-Up | Joe Rossi | Makeup Artist |
| Costume & Make-Up | Kerrie R. Plant | Makeup Artist |
| Directing | Paul Schiff | Second Unit Director |
| Directing | Eddie Micallef | Second Assistant Director |
| Sound | Mark Auguste | Supervising Sound Editor |
