Er zijn twee jaar verstreken sinds de vernietiging van M3GAN, het prototype van kunstmatige intelligentie dat uit de hand liep tijdens een bloedig en onberispelijk gechoreografeerd bloedbad. De maker Gemma, nu een gerenommeerd auteur, voert campagne voor de drastische regulering van AI door de overheid, terwijl Cady, haar 14-jarige nichtje, de adolescentie ingaat en in opstand komt tegen de al te strenge regels van haar tante. Buiten het medeweten van iedereen werd de geavanceerde techniek die voor M3GAN was ontwikkeld, echter gestolen en gekaapt om een militair wapen te maken dat bekend staat als AM3LIA.
Nee, helaas is M3GAN 2.0 nog niet beschikbaar op Netflix in Nederland.
| Production | Judson Scott | Executive Producer |
| Production | Jason Blum | Producer |
| Production | James Wan | Producer |
| Production | Michael Clear | Executive Producer |
| Production | Allison Williams | Producer |
| Production | Mark David Katchur | Executive Producer |
| Production | Adam Hendricks | Executive Producer |
| Production | Greg Gilreath | Executive Producer |
| Writing | Akela Cooper | Characters |
| Writing | James Wan | Characters |
| Writing | Gerard Johnstone | Writer |
| Production | Gerard Johnstone | Executive Producer |
| Directing | Gerard Johnstone | Director |
| Camera | Toby Oliver | Director of Photography |
| Costume & Make-Up | Jeriana San Juan | Costume Design |
| Production | Brittany Fottrell | Post Production Coordinator |
| Production | Sarah Domeier Lindo | Casting |
| Production | Miranda Rivers | Casting |
| Production | Terri Taylor | Casting |
| Art | Brendan Heffernan | Production Design |
| Art | Adam Wheatley | Production Design |
| Art | Tracey Collins | Set Decoration |
| Costume & Make-Up | Sarah Rubano | Makeup Department Head |
| Production | Caz Hearn | Production Coordinator |
| Production | Rebecca Plaistow | Production Coordinator |
| Production | Monique Tourelle | Production Supervisor |
| Crew | Esther Lau Young | Stunts |
| Crew | Alex McColl | Stunts |
| Crew | Karlton Laing | Stunts |
| Writing | Akela Cooper | Story |
| Writing | Gerard Johnstone | Story |
| Sound | Chris Bacon | Original Music Composer |
| Art | Tim Clissold | Set Designer |
| Art | Dylan Coburn | Storyboard Artist |
| Crew | Hamish Drummond | Carpenter |
| Production | Mark David Katchur | Production Coordinator |
| Directing | Rafly Ambadar | Third Assistant Director |
| Directing | Jessica Blennerhassett | Third Assistant Director |
| Directing | Guy Campbell | First Assistant Director |
| Directing | Laura Hutton | Second Second Assistant Director |
| Crew | Tom Kelly | Set Production Assistant |
| Directing | Pikky Lim | Second Assistant Director |
| Crew | Oscar Smit | Set Production Assistant |
| Art | Nick Komornicki | Property Master |
| Art | Dan Milligan | Storyboard Artist |
| Art | Kate Muir | Graphic Designer |
| Art | Electra Sinclair | Graphic Designer |
| Art | Deen Wimbrow | Set Dresser |
| Sound | Kyle Arzt | Sound Re-Recording Mixer |
| Sound | Smokey Cloud | Sound Editor |
| Sound | Joel Dougherty | Sound Re-Recording Mixer |
| Sound | P.K. Hooker | Sound Designer |
| Sound | P.K. Hooker | Supervising Sound Editor |
| Sound | Andrea Horta | Dialogue Editor |
| Sound | Trino Madriz | ADR Mixer |
| Sound | Mehrnaz Mohabati | ADR Mixer |
| Sound | Michael Miller | ADR Mixer |
| Crew | Ashlee Fidow | Stunt Double |
| Editing | Jeff McEvoy | Editor |
| Production | Jennifer Scudder Trent | Co-Producer |
| Production | Luke Sharpe | Executive Producer |
| Production | Jon Romano | Co-Producer |
| Production | Sarah Paek | Executive Producer's Assistant |
| Production | Annie Smith | Executive Producer's Assistant |
| Production | Jack Donaldson | Producer's Assistant |
| Crew | Jeff Sanca | Stunt Driver |
| Costume & Make-Up | Sarah Rubano | Hair Department Head |
| Crew | Daniel Andrews | Stunts |
| Crew | Matt Bowden | Stunts |
| Crew | Tolga Degirmen | Fight Choreographer |
| Crew | Michelle Goh | Stunts |
| Crew | Scott Marsh | Stunts |
| Crew | Tori Marsh | Stunts |
| Crew | Chris Webb | Stunts |
| Crew | Karen Thompson | Stunts |
| Crew | Kiara Pascale | Stunts |
| Crew | Tim McLachlan | Stunts |
| Crew | Alec McColl | Stunts |
