Mollie en James proberen samen (de inmiddels oudere) Mickey en zijn baby-zusje Julie groot te brengen. Broer en zus hebben onderling echter wat spanningen, evenals met Stuart: Mollie's broer die bij hen komt wonen.
Nee, helaas is Look Who's Talking Too nog niet beschikbaar op Netflix in Nederland.
| Editing | Debra Chiate | Editor |
| Camera | Thomas Del Ruth | Director of Photography |
| Directing | Amy Heckerling | Director |
| Production | Jonathan D. Krane | Producer |
| Writing | Amy Heckerling | Writer |
| Writing | Neal Israel | Writer |
| Sound | David Kitay | Original Music Composer |
| Writing | Amy Heckerling | Characters |
| Crew | Allen Benjamin | Special Effects Coordinator |
| Art | Richard Wilcox | Art Direction |
| Costume & Make-Up | Molly Maginnis | Costume Design |
| Art | Reuben Freed | Production Design |
| Art | Barry W. Brolly | Set Decoration |
| Crew | Rick Avery | Stunt Coordinator |
| Directing | Judy Slattery | Third Assistant Director |