Een 'spin-off' van de film 'Knocked Up', die een kijkje geeft in het leven van Pete en Debbie. Ze zijn inmiddels ouder geworden en er is een hoop gebeurd. Voor hun inkomsten zijn ze afhankelijk van Debbie's kledingwinkel. Ze lopen daarnaast rond met de grote vragen des levens. "Hebben ze wel de juiste keuzes gemaakt?" "Is dit hun plaats in de wereld?" En: "Is dit nu echt alles?" Alle dromen die zij hadden als kind, alle mogelijkheden, is dat nu verpest door een simpel huwelijk en het nemen van wat kinderen?
Nee, helaas is This Is 40 nog niet beschikbaar op Netflix in Nederland.
| Production | Lisa Goldberg | Co-Producer |
| Production | Judd Apatow | Producer |
| Directing | Judd Apatow | Director |
| Production | Clayton Townsend | Producer |
| Production | Barry Mendel | Producer |
| Writing | Judd Apatow | Screenplay |
| Sound | Jon Brion | Original Music Composer |
| Art | Andrew Max Cahn | Art Direction |
| Sound | Ken McLaughlin | Production Sound Mixer |
| Sound | Marc Fishman | Sound Re-Recording Mixer |
| Art | Leslie A. Pope | Set Decoration |
| Sound | Jonathan Karp | Music Supervisor |
| Camera | Suzanne Hanover | Still Photographer |
| Costume & Make-Up | Leesa Evans | Costume Design |
| Crew | Joel Kramer | Stunt Coordinator |
| Sound | Cindy Marty | Sound Effects Editor |
| Production | Barrett J. Leigh | Production Supervisor |
| Camera | David Luckenbach | Steadicam Operator |
| Sound | George H. Anderson | Supervising Sound Editor |
| Editing | David L. Bertman | Editor |
| Art | Jefferson Sage | Production Design |
| Production | Paula Pell | Executive Producer |
| Production | Allison Jones | Casting |
| Camera | Phedon Papamichael | Director of Photography |
| Editing | Brent White | Editor |
| Sound | Adam Jenkins | Sound Re-Recording Mixer |
| Editing | Jay Deuby | Editor |
| Directing | Valeria Migliassi Collins | Script Supervisor |
| Camera | David Luckenbach | Camera Operator |
| Costume & Make-Up | Dan Bronson | Costume Supervisor |
| Crew | Riley Harper | Stunts |
| Sound | Larry Kemp | Dialogue Editor |
| Costume & Make-Up | Linda Arnold | Hair Department Head |
| Directing | Matt Rebenkoff | First Assistant Director |
| Sound | Tammy Fearing | ADR Supervisor |
| Sound | James Matheny | Dialogue Editor |
| Directing | Joel Kramer | Second Unit Director |
| Art | Sean Mannion | Property Master |
| Crew | Dick Ziker | Stunt Driver |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Debbie Evans | Stunt Driver |
| Crew | Joe Bucaro III | Stunt Double |
| Crew | Tom Elliott | Stunt Driver |
| Art | Erin E. Riegel | Art Department Assistant |
