Nikki, een fanatieke dierenrechtenactiviste, bevrijdt illegaal geïmporteerde exotische slangen uit dierenwinkels. Ze laat ze vrij in de Everglades waar ze uitgroeien tot mega-pythons. De overijverige parkwachter Terry maakt zich grote zorgen over de groeiende ecologische schade. Om haar geliefde alligators te redden voert ze gevaarlijke methodes uit waarbij ze zowel een oorlog start tussen de pythons en de alligators als met Nikki.
Nee, helaas is Mega Python vs. Gatoroid nog niet beschikbaar op Netflix in Nederland.
| Directing | Mary Lambert | Director |
| Lighting | Brendon Phillips | Gaffer |
| Crew | Tony Snegoff | Stunts |
| Crew | Laurence Todd Rosenthal | Stunts |
| Crew | Cole S. McKay | Utility Stunts |
| Crew | Mam Smith | Stunt Double |
| Crew | Chris Papajohn | Utility Stunts |
| Visual Effects | Sasha Burrow | VFX Artist |
| Production | Christopher Ray | Line Producer |
| Production | Debbie Gibson | Co-Producer |
| Production | David L. Garber | Associate Producer |
| Production | Paul Bales | Co-Producer |
| Camera | Troy Smith | Director of Photography |
| Costume & Make-Up | Teri Groves | Key Makeup Artist |
| Camera | Alexander Yellen | Camera Operator |
| Production | Michael C. Parisi | Location Manager |
| Visual Effects | Mark Kochinski | Visual Effects Supervisor |
| Art | Aaron Bautista | Art Direction |
| Costume & Make-Up | Reneé Parry | Assistant Makeup Artist |
| Crew | Mark Quod | Post Production Supervisor |
| Crew | Sean Christopher | Stunts |
| Camera | Conner Vandeer | Steadicam Operator |
| Art | Niko Vilaivongs | Production Design |
| Sound | Brett Bach | Supervising Sound Editor |
| Sound | Craig Polding | Sound Re-Recording Mixer |
| Camera | Alexander Yellen | Second Unit Director of Photography |
| Directing | Carlos Reza | Second Assistant Director |
| Costume & Make-Up | Katie Machaiek | Assistant Makeup Artist |
| Directing | Thomas Kuk | First Assistant Director |
| Sound | Brett Bach | Sound Re-Recording Mixer |
| Sound | Matt Schwartz | Sound Effects Editor |
| Crew | Spice Williams-Crosby | Stunt Double |
| Art | Jocelyn Collins | Property Master |
| Visual Effects | Emanuel Rosario | VFX Artist |
| Production | Catherine Ames | Production Assistant |
| Production | Thomas P. Vitale | Executive Producer |
| Visual Effects | Joseph J. Lawson | Visual Effects Supervisor |
| Editing | Mark Quod | Colorist |
| Production | David Michael Latt | Producer |
| Production | Karen O'Hara | Associate Producer |
| Production | Scotty Atkins | Associate Producer |
| Editing | Shawn David Thompson | Editor |
| Costume & Make-Up | Michelle Matteo | Costume Design |
| Directing | Suzanne C. Swindle | Script Supervisor |
| Production | Ray Cannella | Associate Producer |
| Production | David Rimawi | Executive Producer |
| Production | Tiffany | Co-Producer |
| Production | Thomas Kuk | Unit Production Manager |
| Production | Glenn Miller | Casting |
| Crew | Karin Justman | Stunt Double |
| Sound | Fred Paragano | ADR Mixer |
| Crew | Steve Hart | Stunt Coordinator |
| Camera | Calvin Cairns | Still Photographer |
| Production | Mary E. Brown | Production Supervisor |
| Sound | Lisa Ries | Sound Editor |
| Visual Effects | Aaron Witlin | VFX Artist |
| Costume & Make-Up | Laura Peyer | Costumer |
| Costume & Make-Up | Jason Griffin | Assistant Costume Designer |
| Sound | Thomas Corkran | Sound Mixer |
| Sound | Brian Calhoon | ADR Recordist |
| Crew | Ashley Carr | Post Production Assistant |
| Production | Ashley Carr | Casting Assistant |
| Sound | Chris Ridenhour | Original Music Composer |
| Writing | Naomi L. Selfman | Writer |
| Crew | Elliot Gannon | Set Production Assistant |
