Nikki, een fanatieke dierenrechtenactiviste, bevrijdt illegaal geïmporteerde exotische slangen uit dierenwinkels. Ze laat ze vrij in de Everglades waar ze uitgroeien tot mega-pythons. De overijverige parkwachter Terry maakt zich grote zorgen over de groeiende ecologische schade. Om haar geliefde alligators te redden voert ze gevaarlijke methodes uit waarbij ze zowel een oorlog start tussen de pythons en de alligators als met Nikki.
Nee, helaas is Mega Python vs. Gatoroid nog niet beschikbaar op Netflix in Nederland.
| Directing | Mary Lambert | Director |
| Crew | Mam Smith | Stunt Double |
| Crew | Tony Snegoff | Stunts |
| Crew | Chris Papajohn | Utility Stunts |
| Crew | Cole S. McKay | Utility Stunts |
| Crew | Laurence Todd Rosenthal | Stunts |
| Lighting | Brendon Phillips | Gaffer |
| Visual Effects | Sasha Burrow | VFX Artist |
| Production | Scotty Atkins | Associate Producer |
| Production | David Michael Latt | Producer |
| Production | Christopher Ray | Line Producer |
| Production | David Rimawi | Executive Producer |
| Camera | Troy Smith | Director of Photography |
| Production | Paul Bales | Co-Producer |
| Production | Ray Cannella | Associate Producer |
| Production | Karen O'Hara | Associate Producer |
| Production | Debbie Gibson | Co-Producer |
| Production | David L. Garber | Associate Producer |
| Sound | Brett Bach | Sound Re-Recording Mixer |
| Production | Catherine Ames | Production Assistant |
| Art | Jocelyn Collins | Property Master |
| Crew | Spice Williams-Crosby | Stunt Double |
| Costume & Make-Up | Laura Peyer | Costumer |
| Editing | Shawn David Thompson | Editor |
| Sound | Lisa Ries | Sound Editor |
| Visual Effects | Emanuel Rosario | VFX Artist |
| Costume & Make-Up | Jason Griffin | Assistant Costume Designer |
| Sound | Fred Paragano | ADR Mixer |
| Camera | Conner Vandeer | Steadicam Operator |
| Crew | Karin Justman | Stunt Double |
| Production | Glenn Miller | Casting |
| Directing | Carlos Reza | Second Assistant Director |
| Crew | Steve Hart | Stunt Coordinator |
| Costume & Make-Up | Michelle Matteo | Costume Design |
| Crew | Sean Christopher | Stunts |
| Production | Thomas P. Vitale | Executive Producer |
| Costume & Make-Up | Reneé Parry | Assistant Makeup Artist |
| Crew | Mark Quod | Post Production Supervisor |
| Visual Effects | Joseph J. Lawson | Visual Effects Supervisor |
| Visual Effects | Aaron Witlin | VFX Artist |
| Production | Thomas Kuk | Unit Production Manager |
| Sound | Brett Bach | Supervising Sound Editor |
| Sound | Thomas Corkran | Sound Mixer |
| Sound | Brian Calhoon | ADR Recordist |
| Camera | Alexander Yellen | Second Unit Director of Photography |
| Sound | Craig Polding | Sound Re-Recording Mixer |
| Visual Effects | Mark Kochinski | Visual Effects Supervisor |
| Art | Aaron Bautista | Art Direction |
| Costume & Make-Up | Teri Groves | Key Makeup Artist |
| Production | Mary E. Brown | Production Supervisor |
| Editing | Mark Quod | Colorist |
| Production | Tiffany | Co-Producer |
| Art | Niko Vilaivongs | Production Design |
| Directing | Thomas Kuk | First Assistant Director |
| Camera | Calvin Cairns | Still Photographer |
| Directing | Suzanne C. Swindle | Script Supervisor |
| Costume & Make-Up | Katie Machaiek | Assistant Makeup Artist |
| Sound | Matt Schwartz | Sound Effects Editor |
| Camera | Alexander Yellen | Camera Operator |
| Production | Michael C. Parisi | Location Manager |
| Crew | Ashley Carr | Post Production Assistant |
| Production | Ashley Carr | Casting Assistant |
| Sound | Chris Ridenhour | Original Music Composer |
| Writing | Naomi L. Selfman | Writer |
| Crew | Elliot Gannon | Set Production Assistant |
