Het verhaal draait om de nieuwe middelbare school leerling Jo, die er mee instemt om bevriend te worden met de buitenstaander Abby. Dit op aandringen van Abby's rijke vader in ruil voor het betalen van alle kosten voor de studie van haar dromen. Jo en Abby gaan samen de strijd aan tegen de "gemene meiden" van de school die bekend staan onder naam "Plastics". Uiteindelijk komt het tot een confrontatie wanneer Abby er achter komt dat de vriendschap is gekocht.
Nee, helaas is Mean Girls 2 nog niet beschikbaar op Netflix in Nederland.
| Directing | Melanie Mayron | Director |
| Writing | Cliff Ruby | Writer |
| Writing | Elana Lesser | Writer |
| Writing | Allison Schroeder | Writer |
| Production | George Engel | Line Producer |
| Sound | Billy Gottlieb | Music Supervisor |
| Production | Harriet Greenspan | Casting |
| Production | Lisa Mae Fincannon | Local Casting |
| Production | Craig Fincannon | Local Casting |
| Production | Mark Fincannon | Local Casting |
| Production | George Engel | Unit Production Manager |
| Directing | Linda Brachman | First Assistant Director |
| Directing | Alison C. Rosa | Second Assistant Director |
| Costume & Make-Up | Kitty Boots | Costume Designer |
| Crew | Lonnie R. Smith Jr. | Stunt Coordinator |
| Crew | Kirsten Banka | Stunts |
| Crew | Lena Fennema | Stunts |
| Crew | Aby Martin | Stunts |
| Crew | Michele Waitman | Stunts |
| Crew | Elizabeth Davidovich | Stunts |
| Art | Kristen McGary | Set Decoration |
| Camera | Michael St. Hilaire | Camera Operator |
| Camera | Joseph Thomas | First Assistant Camera |
| Camera | Mike Torino | Second Assistant Camera |
| Camera | Mark J. Coyne | Steadicam Operator |
| Camera | Nano Segler | First Assistant "B" Camera |
| Camera | Scott Ippolito | Second Assistant "B" Camera |
| Camera | Matthew Horn | Camera Loader |
| Directing | Lesley King | Script Supervisor |
| Sound | Eric M. Moorman | Sound Mixer |
| Sound | Christopher Cimaglia | Boom Operator |
| Lighting | Daniel Murphy | Chief Lighting Technician |
| Lighting | Jon Ladd | Assistant Chief Lighting Technician |
| Art | Kristina Kilpe | Property Master |
| Art | Angie Woodard | Assistant Property Master |
| Crew | Lisa Reynolds | Special Effects Coordinator |
| Crew | Tyler C. Martin | Special Effects Technician |
| Production | Mark Cottrell | Location Manager |
| Production | Kai Thorup | Assistant Location Manager |
| Art | Beth Wheeler | Leadman |
| Art | Andy Rusk | Set Dresser |
| Art | Erin Santini | Set Dresser |
| Art | Laurence Laufer | Set Dresser |
| Art | Jose Libao | Set Dresser |
| Costume & Make-Up | Joulles Wright | Costume Supervisor |
| Costume & Make-Up | K. Drew Fuller | Key Costumer |
| Costume & Make-Up | E. Dee Biddlecome | Costumer |
| Costume & Make-Up | Kate Duke | Costumer |
| Costume & Make-Up | Sarah Downer | Costumer |
| Costume & Make-Up | Carol Rasheed | Makeup Department Head |
| Costume & Make-Up | Mi Young | Key Makeup Artist |
| Costume & Make-Up | Patrice Coleman | Makeup Artist |
| Costume & Make-Up | Veronica Cox | Makeup Artist |
| Costume & Make-Up | Denise Tunnell | Makeup Artist |
| Costume & Make-Up | Vanessa Davis-Kaib | Hair Department Head |
| Costume & Make-Up | Heather Morris | Key Hair Stylist |
| Costume & Make-Up | Cynthia L. Chapman | Hairstylist |
| Costume & Make-Up | Dawn Turner | Hairstylist |
| Production | Susan Putnam | Casting Associate |
| Production | Tara Bennett | Casting Associate |
| Production | Bill Marinella | Background Casting Director |
| Art | Lisa Yeiser | Graphic Designer |
| Art | Rhyan A. Minter | Art Department Coordinator |
| Production | John Burton West | Production Supervisor |
| Production | Mary Jane Nolan Kelly | Production Coordinator |
| Directing | Tim Fitzgerald | Second Second Assistant Director |
| Camera | Annette Brown | Still Photographer |
| Camera | Russell Kaye | Still Photographer |
| Camera | Bob Mahoney | Still Photographer |
| Editing | Vaune Kirby Frechette | Assistant Editor |
| Crew | Neysa Frechette | Post Production Assistant |
| Crew | Bobbie Shay | Post Production Assistant |
| Sound | Jay Nierenberg | Sound Designer |
| Sound | Jay Nierenberg | Sound Supervisor |
| Sound | Todd Niesen | Sound Editor |
| Sound | Stuart Provine | Sound Editor |
| Sound | Angelo Palazzo | Sound Editor |
| Sound | Elizabeth Kenton | Sound Editor |
| Sound | Katrina Frederick | Assistant Sound Editor |
| Sound | Jonathan Wales | Sound Mixer |
| Sound | Richard Kitting | Sound Mixer |
| Sound | Jason Gaya | ADR Mixer |
| Production | Leigh French | ADR Voice Casting |
| Sound | Zach Michaelis | Foley Mixer |
| Sound | Vicki O'Reilly Vandegrift | Foley Artist |
| Sound | Kevin McKeever | Music Editor |
| Art | Rich Koll | Construction Coordinator |
| Art | Mark Nave | Construction Foreman |
| Crew | Shannon Black | Scenic Artist |
| Art | Christopher 'Woody' Wdowin | Greensman |
| Visual Effects | Sean Wilson | Visual Effects Compositor |
| Camera | Levie Isaacks | Director of Photography |
| Editing | Michael Jablow | Editor |
