Tien jaar is er verstreken sinds Sidney Prescott (Neve Campbell) haar laatste confrontatie had met de gemaskerde moordenaar Ghostface. Ze leeft nu geïsoleerd en heeft een boek geschreven dat veel lovende kritieken heeft ontvangen. Ze wordt echter uit haar dagelijkse routine getrokken als Ghostface weer verschijnt in Michigan, met als gevolg dat Sidney weer herenigd wordt met Dewey (David Arquette) en Gale (Courtney Cox).
Nee, helaas is Scream 4 nog niet beschikbaar op Netflix in Nederland.
| Directing | Wes Craven | Director |
| Writing | Kevin Williamson | Characters |
| Camera | Peter Deming | Director of Photography |
| Production | Wes Craven | Producer |
| Production | Marianne Maddalena | Executive Producer |
| Production | Ron Schmidt | Executive Producer |
| Writing | Kevin Williamson | Screenplay |
| Production | Kevin Williamson | Producer |
| Crew | Banzai Vitale | Stunt Driver |
| Crew | Eric Bergman | Post Production Supervisor |
| Editing | Brendan Walsh | Additional Editor |
| Production | Cathy Konrad | Executive Producer |
| Production | Carly Feingold | Co-Producer |
| Crew | Troy Brown | Stunt Coordinator |
| Production | Richard E. Chapla Jr. | Production Supervisor |
| Camera | Claire Farrand-Stone | Second Assistant "A" Camera |
| Production | Matthew Stein | Executive Producer |
| Directing | Maria Mantia | Second Assistant Director |
| Production | Iya Labunka | Producer |
| Crew | Patrick Esposito | Post Production Supervisor |
| Sound | Liza Richardson | Music Supervisor |
| Production | Ron Schmidt | Unit Production Manager |
| Camera | David Eubank | First Assistant "A" Camera |
| Production | M.K. Gleason | Production Accountant |
| Camera | George Billinger III | "B" Camera Operator |
| Costume & Make-Up | Diane Crooke | Costume Supervisor |
| Production | Logan Cooper | Location Manager |
| Directing | Lori Grabowski | Script Supervisor |
| Costume & Make-Up | Joy Zapata | Hair Department Head |
| Directing | Anastacia C. Nemec | Second Second Assistant Director |
| Art | J.P. Jones | Property Master |
| Production | Georgina Marquis | Production Coordinator |
| Costume & Make-Up | Maggie Fung | Key Makeup Artist |
| Art | Skip Crank | Assistant Property Master |
| Camera | Philip Sloan | Key Grip |
| Sound | Jeffree Bloomer | Production Sound Mixer |
| Directing | Nicholas Mastandrea | First Assistant Director |
| Lighting | Jay Fortune | Gaffer |
| Camera | Phil Bray | Still Photographer |
| Costume & Make-Up | Catherine Hahn | Key Costumer |
| Crew | Riley Harper | Stunt Double |
| Sound | Anthony Cargioli | Boom Operator |
| Costume & Make-Up | Megan Wiser | Costumer |
| Costume & Make-Up | Norma Lee | Key Hair Stylist |
| Art | Thomas Traugott | Leadman |
| Camera | Gemma La Mana | Still Photographer |
| Visual Effects | Ron Bolanowski | Special Effects Supervisor |
| Costume & Make-Up | Gary J. Tunnicliffe | Prosthetic Designer |
| Costume & Make-Up | Dawn Mattocks | Hairstylist |
| Costume & Make-Up | Peter Robb-King | Makeup Department Head |
| Costume & Make-Up | Jennifer Kamrath | Key Costumer |
| Art | Jody Gaber | Art Department Coordinator |
| Art | Emma Stensaas | Art Department Assistant |
| Costume & Make-Up | Kristi Hoffman | Set Costumer |
| Lighting | Brad Irvin | Electrician |
| Camera | Spencer M. Rohan | Grip |
| Lighting | Anthony 'Spike' Simms | Rigging Gaffer |
| Camera | Kevin Fannon | Grip |
| Camera | Tony Boura | Grip |
| Camera | Paul Wilkowsky | Best Boy Grip |
| Camera | Steve Alessi | Grip |
| Camera | Brandon Cundiff | Grip |
| Art | Ronald Napier | Construction Foreman |
| Lighting | Brian McClean | Best Boy Electric |
| Sound | Greg Steele | ADR Mixer |
| Sound | Todd Toon | Supervising Sound Editor |
| Sound | Julio Carmona | ADR Recordist |
| Crew | Marcus Trumpp | Additional Music |
| Sound | Joe Barnett | Additional Sound Re-Recording Mixer |
| Production | Kelly Stultz | Payroll Accountant |
| Sound | Darrin Mann | Foley Mixer |
| Sound | Catherine Harper | Foley Artist |
| Sound | Dean St. John | ADR Mixer |
| Editing | Blair Miller | First Assistant Editor |
| Crew | Brandon Roberts | Additional Music |
| Art | Tina Tottis | Set Decoration Buyer |
| Production | M.K. Shaw | Payroll Accountant |
| Sound | Donald J. Malouf | Supervising Sound Editor |
| Sound | Donald J. Malouf | Sound Designer |
| Sound | Patrick Cyccone Jr. | Sound Re-Recording Mixer |
| Sound | Doc Kane | ADR Mixer |
| Sound | Tami Treadwell | ADR Recordist |
| Sound | Victoria Sampson | Supervising ADR Editor |
| Sound | John Kwiatkowski | Sound Editor |
| Sound | Albert Gasser | Sound Editor |
| Sound | Val Kuklowsky | ADR Editor |
| Sound | Greg Zimmerman | ADR Recordist |
| Sound | G.W. Brown | ADR Editor |
| Sound | Pernell L. Salinas | First Assistant Sound Editor |
| Sound | Christian P. Minkler | Sound Re-Recording Mixer |
| Sound | Christopher Moriana | Foley Artist |
| Sound | Robert Deschaine | ADR Mixer |
| Sound | Ron Bedrosian | ADR Mixer |
| Sound | Odin Benitez | Sound Editor |
| Sound | Charles W. Ritter | Sound Editor |
| Production | Ryan Gomez | First Assistant Accountant |
| Sound | Todd Toon | Sound Designer |
| Sound | Julie Altus | ADR Recordist |
| Crew | Dennis Smith | Additional Music |
| Sound | Ben Schor | Music Editor |
| Art | Bruce Schluter | Title Designer |
| Visual Effects | Keith Devlin | Compositing Supervisor |
| Crew | Trevor Strand | Compositor |
| Production | Leeba Zakharov | Casting Associate |
| Crew | Mathew Giampa | Compositor |
| Production | Andy Henry | Casting Associate |
| Production | Sabrina Hyman | Casting Associate |
| Visual Effects | Jon Cowley | VFX Supervisor |
| Crew | John Paesano | Additional Music |
| Production | Charles L. Gariepy | Casting Associate |
| Editing | Mark Sahagun | Digital Intermediate Editor |
| Editing | Carl S.G. Moore | Digital Intermediate Producer |
| Crew | Dane Farwell | Stunts |
| Visual Effects | Michael D'Sa | Visual Effects Producer |
| Art | Sarah Ivey | Set Dresser |
| Visual Effects | Reupal D Rawal | Visual Effects Supervisor |
| Visual Effects | Jamison Scott Goei | Visual Effects Supervisor |
| Visual Effects | Arushi Govil | VFX Artist |
| Art | Mark Sejnowski | Set Dresser |
| Visual Effects | Shome Dasgupta | Visual Effects Producer |
| Art | Kurt Braun | Set Dresser |
| Crew | Brian Avery | Stunts |
| Crew | Karin Silvestri | Stunts |
| Art | Adam Stockhausen | Production Design |
| Sound | Marco Beltrami | Original Music Composer |
| Production | Harvey Weinstein | Executive Producer |
| Production | Bob Weinstein | Executive Producer |
| Crew | Keith Levine | Thanks |
| Production | Ehren Kruger | Executive Producer |
| Production | Avy Kaufman | Casting |
| Editing | Peter McNulty | Editor |
| Production | Nancy Nayor | Casting |
| Costume & Make-Up | Debra McGuire | Costume Design |
| Art | Helen Britten | Set Decoration |
| Art | Gerald Sullivan | Art Direction |
| Crew | Dana Reed | Stunt Double |
| Crew | Cassidy Vick Hice | Stunt Double |
| Crew | Allison Caetano | Stunt Double |
| Crew | Karin Silvestri | Stunt Double |
| Crew | Stacey Carino | Stunt Double |
| Crew | Ann Scott | Stunt Double |
| Crew | William Bernardin | In Memory Of |
| Crew | Renae Moneymaker | Stunts |
| Crew | Dailyn Matthews | Stunts |
| Crew | Alexander Punch | Production Intern |
| Crew | Edward Smith Taylor | Prop Maker |
| Editing | Michael Hatzer | Digital Intermediate Colorist |
