Lucy (Scarlett Johansson) is een jonge vrouw die op vreselijke wijze gedwongen wordt om drugs te smokkelen. Per ongeluk komt zij in aanraking met de drugs, die haar op een mysterieuze manier bovenmenselijke krachten geven. Ze kan kennis direct absorberen, is in staat om objecten met haar geest te verplaatsen en ze kan geen pijn of leed voelen. Ze trekt vervolgens ten strijde tegen de onverlaten die haar te grazen namen.
| Directing | Luc Besson | Director |
| Writing | Luc Besson | Writer |
| Production | Virginie Besson-Silla | Producer |
| Production | Marc Shmuger | Executive Producer |
| Production | Nathalie Chéron | Casting |
| Art | Hugues Tissandier | Production Design |
| Art | Gilles Boillot | Art Direction |
| Art | Dominique Moisan | Art Direction |
| Art | Stéphane Robuchon | Art Direction |
| Art | Thierry Zemmour | Art Direction |
| Art | Evelyne Tissandier | Set Decoration |
| Costume & Make-Up | Olivier Bériot | Costume Design |
| Art | Christophe Chabenet | Sculptor |
| Art | Charlie Clerc | Assistant Art Director |
| Art | Anne-Sophie Delaunay | Assistant Art Director |
| Art | Paulo Gonçalves | Assistant Art Director |
| Art | Virginie Irdel | Assistant Art Director |
| Art | Ben Mauro | Conceptual Design |
| Art | Eduardo Pena | Conceptual Design |
| Sound | Guillaume Bouchateau | Supervising Sound Editor |
| Sound | Régis Boussin | Boom Operator |
| Editing | Matthieu Dallaporta | Dialogue Editor |
| Sound | Aymeric Devoldère | Sound Designer |
| Sound | Lionel Dousset | Boom Operator |
| Sound | Shannon Mills | Sound Designer |
| Crew | Jean-Christophe Magnaud | Special Effects Coordinator |
| Visual Effects | Kevin Berger | Visual Effects Supervisor |
| Visual Effects | Richard Bluff | Visual Effects Supervisor |
| Visual Effects | Marie-Cecile Dahan | Visual Effects Producer |
| Visual Effects | Valerie Delahaye | Visual Effects Producer |
| Visual Effects | Simon Descamps | Visual Effects Producer |
| Visual Effects | François Dumoulin | Visual Effects Supervisor |
| Visual Effects | Brice Liesveld | Visual Effects Producer |
| Visual Effects | James Pastorius | Visual Effects Supervisor |
| Lighting | Gregory Fromentin | Gaffer |
| Sound | Samuel Potin | Music Editor |
| Production | Adrien Adriaco | Location Manager |
| Directing | Isabelle Querrioux | Script Supervisor |
| Crew | Raimundo Querido | Stunts |
| Camera | Thierry Arbogast | Director of Photography |
| Sound | Éric Serra | Original Music Composer |
| Costume & Make-Up | Stéphane Robert | Makeup Artist |
| Costume & Make-Up | Florence Batteault | Makeup Artist |
| Costume & Make-Up | Marie Gombeaud-Antoine | Makeup Artist |
| Costume & Make-Up | Nathalie Regior | Makeup Artist |
| Costume & Make-Up | Marthe Faucouit | Makeup Artist |
| Costume & Make-Up | Anne Moralis | Wigmaker |
| Production | Thierry Guilmard | Production Manager |
| Sound | Shannon Mills | Supervising Sound Editor |
| Sound | Guillaume Bouchateau | Sound Designer |
| Sound | Jeremy Bowker | Sound Effects Editor |
| Sound | Sébastien Jeannot | Sound Effects Editor |
| Sound | Matthieu Dallaporta | Sound Re-Recording Mixer |
| Sound | Didier Lozahic | Sound Re-Recording Mixer |
| Editing | Didier Lozahic | Editor |
| Visual Effects | Sophie Leclerc | Visual Effects Producer |
| Visual Effects | Ryan Wiederkehr | Visual Effects Producer |
| Crew | Daniel Perez Ferreira | CG Supervisor |
| Crew | Laurent Demianoff | Stunt Coordinator |
| Camera | Jean-Baptiste Jay | Camera Operator |
| Camera | Larry McConkey | Steadicam Operator |
| Camera | Lorenzo Donati | Steadicam Operator |
| Camera | Mark Gerasimenko | Helicopter Camera |
| Camera | Marion Gaillard | Additional Camera |
| Camera | Jessica Forde | Still Photographer |
| Production | Marc Guidetti | Location Manager |
| Production | Jérémy Petetin | Location Manager |
| Production | Nour Rakotobe | Production Accountant |
| Production | Todd Spears | Production Accountant |
| Sound | Aiden Ramos | Sound Recordist |
| Costume & Make-Up | Frédérique Foglia | Special Effects Makeup Artist |
| Costume & Make-Up | Sylvie Ferry | Special Effects Makeup Artist |
| Crew | Alain Villain | Stunt Driver |
| Crew | Virginie Arnaud | Stunt Driver |
| Crew | Eric Barone | Stunt Driver |
| Crew | Sybille Blouin | Stunt Driver |
| Crew | Alain Figlarz | Stunt Coordinator |
| Crew | Michelle Figlarz | Stunts |
| Crew | Pascaline Girardot | Stunt Driver |
| Crew | Yvonne Ho | Stunt Driver |
| Crew | Catherine Lebegue | Stunt Driver |
| Crew | Stéphane Lefebvre | Stunt Driver |
| Crew | Alice Naigeon | Stunt Driver |
| Crew | Alicia Vela-Bailey | Stunt Double |
| Crew | Stéphane Orsolani | Stunts |
| Crew | Marc Bizet | Stunts |
| Crew | Francis Bataille | Stunt Driver |
| Art | Olivier Nguyen | Property Master |
| Art | Guy Monbillard | Property Master |
| Camera | Julien Bachelier | Digital Imaging Technician |
| Crew | Amedéo Cazzella | Stunts |
