Charlie Fineman en Alan Johnson zijn oud-studiegenoten die het contact met elkaar verloren hebben. Ze lopen elkaar toevallig tegen het lijf in Manhattan en de vriendschap is snel weer opgepakt.
Nee, helaas is Reign Over Me nog niet beschikbaar op Netflix in Nederland.
| Editing | Steve Edwards | Editor |
| Costume & Make-Up | Deborah Lynn Scott | Costume Design |
| Production | Lynwood Spinks | Executive Producer |
| Directing | Mike Binder | Director |
| Production | Jack Giarraputo | Executive Producer |
| Editing | Jeremy Roush | Editor |
| Camera | Russ T. Alsobrook | Director of Photography |
| Writing | Mike Binder | Screenplay |
| Sound | Dave Jordan | Music Supervisor |
| Production | Jack Binder | Producer |
| Art | Christian Wintter | Production Design |
| Production | Michael Rotenberg | Producer |
| Production | Sharon Bialy | Casting |
| Sound | Rolfe Kent | Original Music Composer |
| Directing | Nancy Karlin | Script Supervisor |
| Art | Greg Berry | Art Direction |
| Art | Jon Danniells | Set Decoration |
| Costume & Make-Up | Ann Pala | Makeup Department Head |
| Sound | Marc Glassman | Sound Effects Editor |
| Sound | David Bach | Supervising Sound Editor |
| Sound | Elmo Weber | Supervising Sound Editor |
| Sound | Elmo Weber | Sound Re-Recording Mixer |
| Sound | Cameron Steenhagen | Dialogue Editor |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Joanne Lamstein | Stunts |
| Crew | John Cenatiempo | Stunt Driver |
| Crew | Jennifer Lamb | Stunts |
| Art | David Swayze | Art Direction |
