In september 1983 verhuizen Michaela en Augusto Odone met hun vijfjarig zoontje Lorenzo van de Comoren naar Washington. Voor Lorenzo verloopt de aanpassing moeizaam en hij raakt op school betrokken bij verschillende relletjes. Omdat de incidenten elkaar in een snel tempo opvolgen en het gedrag van Lorenzo almaar meer gestoord wordt, raadpleegt het echtpaar Odone verschillende artsen. Geen van de geconsulteerde dokters weet wat er aan de hand is met de jongen. Pas in 1984 velt dokter Judalon het verdict: Lorenzo heeft de zeldzame en mysterieuze ziekte ALD, een afwijking van het metabolisme waardoor de hersenen afsterven. Een therapie is er niet en de ontwikkeling is niet te stuiten. Lorenzo heeft nog maar twee jaar te leven...
Nee, helaas is Lorenzo's Oil nog niet beschikbaar op Netflix in Nederland.
| Editing | Richard Francis-Bruce | Editor |
| Art | Kristi Zea | Production Design |
| Art | Karen O'Hara | Set Decoration |
| Production | Doug Mitchell | Producer |
| Editing | Marcus D'Arcy | Editor |
| Directing | George Miller | Director |
| Production | Arnold Burk | Executive Producer |
| Production | George Miller | Producer |
| Camera | John Seale | Director of Photography |
| Costume & Make-Up | Colleen Atwood | Costume Design |
| Editing | Patricia A. Galvin | Assistant Editor |
| Camera | Mikki Ansin | Still Photographer |
| Editing | Jane Moran | Assistant Editor |
| Editing | Leilani Hannah | Assistant Editor |
| Directing | Daphne Paris | Script Supervisor |
| Editing | Rick Lisle | Assistant Editor |
| Editing | Carol A. Ellison Fleming | Assistant Editor |
| Editing | Kimberly Walls | Assistant Editor |
| Editing | Jane Maguire | First Assistant Editor |
| Editing | Paula Lourie | First Assistant Editor |
| Production | Chris Brigham | Unit Production Manager |
| Directing | Steve E. Andrews | First Assistant Director |
| Directing | Philip A. Patterson | Second Assistant Director |
| Production | Johnny Friedkin | Associate Producer |
| Production | Daphne Paris | Associate Producer |
| Production | Lynn O'Hare | Associate Producer |
| Art | Dennis Bradford | Art Direction |
| Sound | Christine Woodruff | Music Supervisor |
| Writing | George Miller | Writer |
| Writing | Nick Enright | Writer |
| Sound | Ben Osmo | Production Sound Mixer |
| Sound | Lee Smith | Sound Designer |
| Sound | Roger Savage | Sound Re-Recording Mixer |
| Sound | Annabelle Sheehan | ADR Editor |
| Sound | Livia Ruzic | Dialogue Editor |
| Sound | Wayne Pashley | Dialogue Editor |
| Sound | Gareth Vanderhope | Sound Editor |
| Sound | Peter Townend | Sound Editor |
| Sound | Tim Jordan | Sound Editor |
| Sound | Steve Burgess | Foley Editor |
| Sound | Jerry Long | Foley Editor |
| Sound | Ian McLoughlin | Additional Sound Re-Recording Mixer |
| Sound | Robert Deschaine | ADR Mixer |
| Sound | David Jobe | ADR Recordist |
| Sound | Paul Zydel | ADR Mixer |
| Production | Catherine Barber | Finance |
| Production | Robin Douet | Production Supervisor |
| Production | Neri Kyle Tannenbaum | Location Manager |
| Production | Ellen M. Hillers | Production Coordinator |
| Art | Ken Turner | Lead Set Dresser |
| Art | Brad Einhorn | Property Master |
| Art | Andrew M. Siegel | Assistant Property Master |
| Art | John Wingrove | Art Direction Intern |
| Art | S. Bruce Wineinger | Construction Coordinator |
| Crew | Eileen Garrigan | Scenic Artist |
| Costume & Make-Up | Fabrizio Sforza | Makeup Artist |
| Costume & Make-Up | David Forrest | Makeup Artist |
| Costume & Make-Up | Linda Matthews | Wardrobe Supervisor |
| Costume & Make-Up | David Davenport | Wardrobe Supervisor |
| Camera | Brian W. Armstrong | Camera Operator |
| Camera | Bobby Mancuso | First Assistant Camera |
| Camera | Brian S. Osmond | Second Assistant Camera |
| Lighting | Reg Garside | Gaffer |
| Lighting | Andrew M. Nelson | Best Boy Electric |
| Lighting | Rick Maddux | Electrician |
| Camera | Robin Alan Knight | Key Grip |
| Camera | Dennis M. Kuneff | Best Boy Grip |
| Camera | Chuck Brown | Dolly Grip |
| Production | Johnny Friedkin | Publicist |
| Production | Katie Clarke | Assistant Accountant |
| Production | Jessica L. Abrams | Assistant Production Coordinator |
| Production | Annie Loeffler | Assistant Location Manager |
| Production | Fred Sandusky | Location Assistant |
| Art | Carol McClenahan | Location Scout |
| Art | Michael Kuhling | Assistant Art Director |
| Art | Francine Byrne | Art Department Coordinator |
| Art | Gary Kosko | Draughtsman |
