Henry Roth werkt bij een groot aquarium-complex in Hawaii. Hij wordt verliefd op Lucy, een meisje dat aan korte termijn-geheugenverlies lijdt. Om een relatie met haar aan te knopen moet Henry dus elke keer opnieuw zijn best doen zodat Lucy weer verliefd op hem wordt.
Nee, helaas is 50 First Dates nog niet beschikbaar op Netflix in Nederland.
| Writing | George Wing | Screenplay |
| Directing | Peter Segal | Director |
| Camera | Jack N. Green | Director of Photography |
| Editing | Jeff Gourson | Editor |
| Production | Kevin Grady | Associate Producer |
| Production | Michael Ewing | Executive Producer |
| Production | Jack Giarraputo | Producer |
| Production | Steve Golin | Producer |
| Production | Daniel Lupi | Executive Producer |
| Production | Jay Roach | Executive Producer |
| Production | Scott Bankston | Co-Producer |
| Production | Larry Kennar | Co-Producer |
| Production | Nancy Juvonen | Producer |
| Costume & Make-Up | Rose Librizzi | Makeup Department Head |
| Costume & Make-Up | Lona Vigi | Hairstylist |
| Costume & Make-Up | Pauletta O. Lewis | Key Hair Stylist |
| Costume & Make-Up | Ellen Lutter | Costume Design |
| Camera | Bill Coe | First Assistant Camera |
| Sound | Derek Vanderhorst | Supervising Sound Effects Editor |
| Sound | Cameron Steenhagen | Sound Effects Editor |
| Directing | Nancy Karlin | Script Supervisor |
| Art | Domenic Silvestri | Art Direction |
| Camera | Stephen S. Campanelli | Camera Operator |
| Sound | Michael Dilbeck | Music Supervisor |
| Art | Robert Greenfield | Set Decoration |
| Costume & Make-Up | Jeannie H. Kelly | Assistant Costume Designer |
| Costume & Make-Up | Robin Fredriksz | Makeup Artist |
| Production | Will Weiske | Production Supervisor |
| Production | Susan Ehrhart | Production Coordinator |
| Sound | Stuart Grusin | Music Editor |
| Sound | David Kelson | Production Sound Mixer |
| Costume & Make-Up | Ann Pala | Makeup Artist |
| Visual Effects | Victoria Alonso | Visual Effects Producer |
| Sound | Teddy Castellucci | Original Music Composer |
| Costume & Make-Up | Robert Q. Mathews | Costume Supervisor |
| Crew | Webster Whinery | Stunt Coordinator |
| Sound | Elmo Weber | Supervising Sound Editor |
| Sound | Orada Jusatayanond | Sound Effects Editor |
| Visual Effects | Sheena Duggal | Visual Effects Supervisor |
| Camera | Darren Michaels | Still Photographer |
| Costume & Make-Up | Nancy Tong | Hair Department Head |
| Production | Elizabeth Boykewich | Casting Associate |
| Art | Donald B. Woodruff | Assistant Art Director |
| Sound | J.J. George | Music Editor |
| Art | Alan Au | Production Design |
| Production | Roger Mussenden | Casting |
| Art | David Carberry | Painter |
| Art | Gregory S. Hooper | Set Designer |
| Art | Bill 'Kauhane' Hoyt | Standby Painter |
| Crew | Spooky Stevens | Unit Publicist |
| Art | Bob Skemp | Greensman |
| Costume & Make-Up | Laurel Frushour | Set Costumer |
| Crew | Geno Hart | Transportation Coordinator |
| Visual Effects | Eddie Soria | Visual Effects Coordinator |
| Crew | James D. Bissell | Second Unit |
| Camera | David Gasperik | Additional Camera |
| Crew | John Charles | Software Engineer |
| Lighting | Justin Duval | Electrician |
| Production | Rodney Brown Alamo | Location Manager |
| Crew | Dave Moorer | Set Medic |
| Sound | Pete Anthony | Orchestrator |
| Art | Dru Homer | Art Department Coordinator |
| Art | Karen Higgins | Construction Coordinator |
| Crew | Kirk Huston | Transportation Captain |
| Crew | Alfred Ainsworth | Video Assist Operator |
| Lighting | T. Daniel Scaringi | Rigging Grip |
| Art | Mark Weissenfluh | Leadman |
| Crew | Sandy Reed | Craft Service |
| Crew | Bruce Comtois | Driver |
| Crew | Reid Paul | Digital Effects Supervisor |
| Directing | Laura Weiss | Assistant Director |
| Art | Scott Trimble | Location Scout |
| Camera | Rick Crum | Grip |
| Lighting | Mike Macias | Lighting Technician |
| Production | Megan Mathews | Production Accountant |
| Crew | Skip Kimball | Telecine Colorist |
| Crew | Steve Rhee | Visual Effects Editor |
| Costume & Make-Up | Clare Hallworth | Assistant Costume Designer |
| Crew | Richard Robinson | Propmaker |
| Sound | Robert Jackson | Boom Operator |
| Art | Nicole Nakamoto | Art Department Assistant |
| Crew | Bruce Richter | Carpenter |
| Editing | Dan Muscarella | Color Timer |
| Production | Daniel Lupi | Unit Production Manager |
| Crew | Crystal Michelle | Stunts |
| Sound | Marc Glassman | Foley Editor |
| Sound | Russell Farmarco | ADR Editor |
| Art | Thomas Cobb | Title Designer |
| Camera | Charles Saldaña | Key Grip |
| Sound | Drake Jenevein | Assistant Sound Editor |
| Camera | Shayna Ritenour | Camera Loader |
| Production | Kendra Carter | Casting Assistant |
| Camera | Hans Bjerno | Aerial Director of Photography |
| Editing | Mo Henry | Negative Cutter |
| Directing | Joseph J. Kontra | Second Assistant Director |
| Production | Demelza Cronin | Assistant Production Coordinator |
| Sound | Mike Deasy | Musician |
| Directing | Adam Druxman | First Assistant Director |
| Sound | Daniel Brock | Utility Sound |
| Art | John Puglisi | Conceptual Illustrator |
| Art | Oscar Delgadillo | Set Dresser |
| Costume & Make-Up | Carme Tenuta | Key Makeup Artist |
| Sound | David Bach | ADR Supervisor |
| Camera | James D. Wickman | Dolly Grip |
| Sound | Robert Jackson | Dialogue Editor |
| Sound | Sean Landeros | Sound Recordist |
| Art | Timothy S. Wiles | Property Master |
| Directing | Timothy Grant Engle | Second Second Assistant Director |
| Production | Claudia Bestor | Assistant Location Manager |
| Visual Effects | Lea Lambert | Rotoscoping Artist |
| Art | Chris Samp | Set Painter |
| Visual Effects | Todd Mesher | Visual Effects Compositor |
| Directing | Jim Bissell | Second Unit Director |
| Art | P.K. MacCarthy | Storyboard Artist |
| Sound | Vincent Guisetti | Foley Artist |
| Crew | Roger Kelton | Special Effects Technician |
| Sound | Howard Carle | ADR Mixer |
| Sound | Kyle Rochlin | Foley Mixer |
| Costume & Make-Up | Anthony Franco | Costumer |
| Art | Ricky Johnson | Construction Grip |
| Production | Steven Butensky | Assistant Accountant |
| Lighting | T. Daniel Scaringi | Key Rigging Grip |
| Production | Scott Berrie | Production Assistant |
| Production | Mele K.T. Locey | Extras Casting Assistant |
| Production | Michael Roccuzzo | Payroll Accountant |
| Production | Kenny Gallagher | Second Assistant Accountant |
| Sound | Howard London | ADR Recordist |
| Crew | Brycen Counts | Stunt Double |
| Directing | Matthew D. Smith | Additional Second Assistant Director |
| Editing | Greg Curry | Colorist |
| Visual Effects | Christian Boudman | Digital Compositor |
| Production | Georgina Marquis | Travel Coordinator |
| Art | Martin Charles | Graphic Designer |
| Crew | Adam Pinkstaff | Stunt Driver |
| Lighting | Michael K. O'Melia | Assistant Chief Lighting Technician |
| Production | Brad Kenny | Extras Casting |
| Camera | Matthew Berner | Assistant Camera |
| Editing | Paul McGhee | Digital Color Timer |
| Production | Kerri Smeltzer | Production Secretary |
| Art | Alex Hillkurtz | Storyboard Artist |
| Crew | Michael Adams | Stunts |
| Crew | Katie Wright Pere | Stunts |
| Crew | Paul Eliopoulos | Stunts |
| Crew | Michael T. Brady | Stunts |
| Crew | Gary Guercio | Stunts |
