Brennan Huff (Will Ferrell) en Dale Doback (John C. Reilly), twee verwende volwassen mannen, wonen ieder nog bij hun alleenstaande ouders. Brennan bij zijn moeder en Dale bij zijn vader. Dit makkelijke leventje bevalt hen goed en beide maken geen aanstalten om uit huis te gaan. Er komt echter een kink in de kabel als de moeder van de ene man verliefd wordt op de vader van de andere en ze besluiten te trouwen. De twee mannen worden op deze manier stiefbroers.
Nee, helaas is Step Brothers nog niet beschikbaar op Netflix in Nederland.
| Production | Jimmy Miller | Producer |
| Production | Will Ferrell | Executive Producer |
| Costume & Make-Up | Susan Matheson | Costume Design |
| Art | Clayton Hartley | Production Design |
| Production | Judd Apatow | Producer |
| Writing | Will Ferrell | Screenplay |
| Camera | Oliver Wood | Director of Photography |
| Editing | Brent White | Editor |
| Directing | Adam McKay | Director |
| Production | Adam McKay | Executive Producer |
| Writing | Adam McKay | Screenplay |
| Production | David B. Householter | Executive Producer |
| Sound | Art Rochester | Production Sound Mixer |
| Camera | Gemma La Mana | Still Photographer |
| Directing | Cate Hardman | Script Supervisor |
| Art | Virginia Randolph-Weaver | Art Direction |
| Writing | John C. Reilly | Story |
| Writing | Will Ferrell | Story |
| Writing | Adam McKay | Story |
| Costume & Make-Up | Charlene Amateau | Costume Supervisor |
| Sound | Jon Brion | Original Music Composer |
| Art | Casey Hallenbeck | Set Decoration |
| Sound | Kevin Kaska | Orchestrator |
| Crew | Sonia Izzolena | Stunts |
| Crew | Joni Avery | Stunts |
| Sound | Hal Willner | Music Supervisor |
| Production | Allison Jones | Casting |
| Production | Basil Grillo | Unit Production Manager |
| Directing | Matt Rebenkoff | First Assistant Director |
| Directing | Courtenay Miles | Second Assistant Director |
| Production | Josh Church | Co-Producer |
| Production | Andrew Epstein | Associate Producer |
| Production | Jessica Elbaum | Associate Producer |
| Art | Scott Maginnis | Property Master |
| Camera | Joe Chess | "A" Camera Operator |
| Camera | Michael St. Hilaire | "B" Camera Operator |
| Camera | Maricella Ramirez | First Assistant "A" Camera |
| Camera | Timothy James Kane | First Assistant "B" Camera |
| Camera | Terry Wolcott | Second Assistant "A" Camera |
| Camera | Michael D. Alvarez | Second Assistant "B" Camera |
| Camera | Annika Iltis | Camera Loader |
| Costume & Make-Up | Steve Artmont | Makeup Department Head |
| Costume & Make-Up | Bridget Cook | Hair Department Head |
| Costume & Make-Up | Simone Almekias-Siegl | Key Makeup Artist |
| Costume & Make-Up | Nanci Cascio | Key Hair Stylist |
| Lighting | James B. Crawford | Chief Lighting Technician |
| Costume & Make-Up | Michael A. Russell | Key Costumer |
| Costume & Make-Up | Yvonne Bastidos | Costumer |
| Costume & Make-Up | Susan Strubel | Costumer |
| Camera | Les T. Tomita | Key Grip |
| Camera | Michael T. Travers | Best Boy Grip |
| Sound | Randall L. Johnson | Boom Operator |
| Crew | Paul Murphey | Video Assist Operator |
| Crew | Bruce Minkus | Special Effects Coordinator |
| Production | Gerard Averill | Location Manager |
| Production | Kathryn Mindala | Production Accountant |
| Art | Butch West | Construction Coordinator |
| Art | Brook Mansbridge | Construction Foreman |
| Art | James E. Tocci | Set Designer |
| Art | Mark Sakamoto | Leadman |
| Art | Glenn Forbes | Assistant Property Master |
| Crew | Will Casey | Unit Publicist |
| Crew | Michael Menapace | Transportation Captain |
| Crew | James D. D'Amico | Transportation Co-Captain |
| Editing | Melissa Bretherton | Additional Editor |
| Editing | Michael Hofacre | Assistant Editor |
| Sound | George H. Anderson | Supervising Sound Editor |
| Editing | Mo Henry | Negative Cutter |
| Editing | John Persichetti | Digital Colorist |
| Sound | James Matheny | Dialogue Editor |
| Sound | Larry Kemp | Dialogue Editor |
| Sound | Cindy Marty | Sound Effects Editor |
| Sound | Joe Schiff | Sound Effects Editor |
| Sound | Tammy Fearing | Supervising ADR Editor |
| Sound | Kyle Rochlin | Foley Mixer |
| Sound | Howard London | ADR Mixer |
| Sound | Pamela Kahn | Foley Artist |
| Sound | Vincent Guisetti | Foley Artist |
| Crew | Eddie Braun | Stunts |
| Crew | Rosine 'Ace' Hatem | Stunts |
| Crew | Karine Mauffrey | Utility Stunts |
| Crew | Marguerite Pomerhn Derricks | Choreographer |
