Brennan Huff (Will Ferrell) en Dale Doback (John C. Reilly), twee verwende volwassen mannen, wonen ieder nog bij hun alleenstaande ouders. Brennan bij zijn moeder en Dale bij zijn vader. Dit makkelijke leventje bevalt hen goed en beide maken geen aanstalten om uit huis te gaan. Er komt echter een kink in de kabel als de moeder van de ene man verliefd wordt op de vader van de andere en ze besluiten te trouwen. De twee mannen worden op deze manier stiefbroers.
Nee, helaas is Step Brothers nog niet beschikbaar op Netflix in Nederland.
| Directing | Adam McKay | Director |
| Editing | Brent White | Editor |
| Production | Will Ferrell | Executive Producer |
| Writing | Will Ferrell | Screenplay |
| Production | David B. Householter | Executive Producer |
| Production | Judd Apatow | Producer |
| Production | Adam McKay | Executive Producer |
| Camera | Oliver Wood | Director of Photography |
| Production | Jimmy Miller | Producer |
| Writing | Adam McKay | Screenplay |
| Art | Clayton Hartley | Production Design |
| Costume & Make-Up | Susan Matheson | Costume Design |
| Sound | Hal Willner | Music Supervisor |
| Production | Allison Jones | Casting |
| Production | Basil Grillo | Unit Production Manager |
| Crew | Paul Murphey | Video Assist Operator |
| Sound | Vincent Guisetti | Foley Artist |
| Production | Josh Church | Co-Producer |
| Production | Jessica Elbaum | Associate Producer |
| Lighting | James B. Crawford | Chief Lighting Technician |
| Sound | Joe Schiff | Sound Effects Editor |
| Sound | Howard London | ADR Mixer |
| Sound | Pamela Kahn | Foley Artist |
| Directing | Courtenay Miles | Second Assistant Director |
| Camera | Michael D. Alvarez | Second Assistant "B" Camera |
| Sound | Kyle Rochlin | Foley Mixer |
| Art | Scott Maginnis | Property Master |
| Camera | Terry Wolcott | Second Assistant "A" Camera |
| Costume & Make-Up | Yvonne Bastidos | Costumer |
| Production | Kathryn Mindala | Production Accountant |
| Crew | Michael D. Menapace | Transportation Captain |
| Editing | Mo Henry | Negative Cutter |
| Camera | Joe Chess | "A" Camera Operator |
| Camera | Michael St. Hilaire | "B" Camera Operator |
| Production | Gerard Averill | Location Manager |
| Editing | John Persichetti | Digital Colorist |
| Sound | James Matheny | Dialogue Editor |
| Production | Andrew Epstein | Associate Producer |
| Costume & Make-Up | Steve Artmont | Makeup Department Head |
| Camera | Michael T. Travers | Best Boy Grip |
| Crew | James D. D'Amico | Transportation Co-Captain |
| Camera | Annika Iltis | Camera Loader |
| Costume & Make-Up | Simone Almekias-Siegl | Key Makeup Artist |
| Costume & Make-Up | Nanci Cascio | Key Hair Stylist |
| Art | Glenn Forbes | Assistant Property Master |
| Editing | Melissa Bretherton | Additional Editor |
| Crew | Bruce Minkus | Special Effects Coordinator |
| Editing | Michael Hofacre | Assistant Editor |
| Directing | Matt Rebenkoff | First Assistant Director |
| Costume & Make-Up | Bridget Cook | Hair Department Head |
| Costume & Make-Up | Michael A. Russell | Key Costumer |
| Art | Mark Sakamoto | Leadman |
| Sound | Larry Kemp | Dialogue Editor |
| Camera | Maricella Ramirez | First Assistant "A" Camera |
| Camera | Timothy James Kane | First Assistant "B" Camera |
| Art | Brook Mansbridge | Construction Foreman |
| Sound | Tammy Fearing | Supervising ADR Editor |
| Sound | Randall L. Johnson | Boom Operator |
| Art | Butch West | Construction Coordinator |
| Art | James E. Tocci | Set Designer |
| Crew | Will Casey | Unit Publicist |
| Sound | George H. Anderson | Supervising Sound Editor |
| Costume & Make-Up | Susan Strubel | Costumer |
| Camera | Les T. Tomita | Key Grip |
| Sound | Cindy Marty | Sound Effects Editor |
| Crew | Eddie Braun | Stunts |
| Crew | Karine Mauffrey | Utility Stunts |
| Crew | Marguerite Pomerhn Derricks | Choreographer |
| Art | Virginia Randolph-Weaver | Art Direction |
| Writing | Will Ferrell | Story |
| Sound | Art Rochester | Production Sound Mixer |
| Sound | Jon Brion | Original Music Composer |
| Camera | Gemma La Mana | Still Photographer |
| Writing | John C. Reilly | Story |
| Directing | Cate Hardman | Script Supervisor |
| Art | Casey Hallenbeck | Set Decoration |
| Costume & Make-Up | Charlene Amateau | Costume Supervisor |
| Writing | Adam McKay | Story |
| Sound | Kevin Kaska | Orchestrator |
| Crew | Rosine 'Ace' Hatem | Stunts |
| Crew | Joni Avery | Stunts |
| Crew | Sonia Izzolena | Stunts |
| Costume & Make-Up | Clinton Wayne | Special Effects Makeup Artist |
| Crew | John Robotham | Stunt Coordinator |
