Cheech en Chong ontmoeten elkaar op een verlaten snelweg in de buurt van California. In hun zoektocht naar drugs worden ze per ongeluk vervoerd naar Mexico. Om terug te komen in Amerika gaan ze accoord met een voorstel om een Truck terug de grens over te rijden, niet wetend wat er achterin zit. Onderweg nemen ze ook nog eens een paar lifters mee...
Nee, helaas is Up in Smoke nog niet beschikbaar op Netflix in Nederland.
| Production | John Beug | Associate Producer |
| Editing | Lou Lombardo | Supervising Editor |
| Editing | Scott Conrad | Editor |
| Art | Leon Ericksen | Art Direction |
| Camera | Gene Polito | Director of Photography |
| Writing | Tommy Chong | Writer |
| Writing | Cheech Marin | Writer |
| Production | Lou Adler | Producer |
| Production | Lou Lombardo | Producer |
| Directing | Lou Adler | Director |
| Production | Mike Moder | Unit Production Manager |
| Directing | Mike Moder | Assistant Director |
| Directing | William S. Beasley | Second Assistant Director |
| Camera | Jack Willoughby | Additional Photography |
| Sound | Patrick Mitchell | Sound Mixer |
| Camera | Gaylin P. Schultz | Key Grip |
| Camera | Bernie Schwartz | Dolly Grip |
| Lighting | Lon Massey III | Gaffer |
| Art | Sidney H. Greenwood | Property Master |
| Art | Jerry Kobold | Assistant Property Master |
| Costume & Make-Up | Ernest Misko | Wardrobe Supervisor |
| Costume & Make-Up | Wes Dawn | Makeup Artist |
| Costume & Make-Up | Lola 'Skip' McNalley | Hairstylist |
| Camera | Sidney Ray Baldwin | Still Photographer |
| Editing | Barry B. Leirer | Assistant Editor |
| Editing | Lori Jane Coleman | Assistant Editor |
| Sound | John Wilkinson | Sound Re-Recording Mixer |
| Production | Monica Lauer | Casting |
| Directing | Pamela Alch | Script Supervisor |
