Een schip van het Amerikaans leger zinkt vlakbij een eiland. Het blijkt dat er aan boord van het schip genetisch gemanipuleerde piranha's zijn. Anne Kimbrough komt hier achter omdat ze de dood van haar zoon heeft onderzocht, ze wil alarm slaan maar een hotelmanager is het daarmee niet eens.
Nee, helaas is Piranha II: The Spawning nog niet beschikbaar op Netflix in Nederland.
| Sound | Stelvio Cipriani | Original Music Composer |
| Production | Jeff Schechtman | Producer |
| Art | Vincenzo Medusa | Art Direction |
| Crew | Roberto D'Ettorre Piazzoli | Cinematography |
| Writing | Charles H. Eglee | Screenplay |
| Production | 筑波久子 | Producer |
| Writing | Ovidio G. Assonitis | Screenplay |
| Directing | James Cameron | Director |
| Writing | James Cameron | Screenplay |
| Production | Ovidio G. Assonitis | Executive Producer |
| Directing | Alessandro Vivarelli | Assistant Director |
| Camera | Erich Heindl | Underwater Camera |
| Camera | Ennio Brizzolari | Key Grip |
| Art | Ronnie Lombard | Greensman |
| Camera | Gianni Caramanico | Still Photographer |
| Sound | Roberto Edwin Forrest | Boom Operator |
| Costume & Make-Up | Mirella De Rossi | Hairstylist |
| Editing | Roberto Silvi | Editor |
| Art | Franco Vanorio | Art Direction |
| Directing | Ruggero Salvadori | Assistant Director |
| Camera | Roberto Forges Davanzati | Underwater Camera |
| Editing | Ada Grimaldi | Assistant Editor |
| Art | Stephane Goulet | Property Master |
| Visual Effects | Giannetto De Rossi | Special Effects Supervisor |
| Camera | Roberto D'Ettorre Piazzoli | Underwater Director of Photography |
| Costume & Make-Up | Maurizio Trani | Makeup Artist |
| Camera | Carlo Tafani | Camera Operator |
| Sound | Alessandro Peticca | Sound Editor |
| Art | Stefano Paltrinieri | Art Direction |
| Costume & Make-Up | Nicoletta Ercole | Costume Design |
| Camera | Roberto D'Ettorre Piazzoli | Director of Photography |
| Costume & Make-Up | Giannetto De Rossi | Makeup Designer |
| Lighting | Luigi Pasqualini | Gaffer |
