Een schip van het Amerikaans leger zinkt vlakbij een eiland. Het blijkt dat er aan boord van het schip genetisch gemanipuleerde piranha's zijn. Anne Kimbrough komt hier achter omdat ze de dood van haar zoon heeft onderzocht, ze wil alarm slaan maar een hotelmanager is het daarmee niet eens.
Nee, helaas is Piranha II: The Spawning nog niet beschikbaar op Netflix in Nederland.
| Production | 筑波久子 | Producer |
| Writing | Charles H. Eglee | Screenplay |
| Writing | Ovidio G. Assonitis | Screenplay |
| Crew | Roberto D'Ettorre Piazzoli | Cinematography |
| Directing | James Cameron | Director |
| Sound | Stelvio Cipriani | Original Music Composer |
| Art | Vincenzo Medusa | Art Direction |
| Writing | James Cameron | Screenplay |
| Production | Ovidio G. Assonitis | Executive Producer |
| Production | Jeff Schechtman | Producer |
| Sound | Roberto Edwin Forrest | Boom Operator |
| Camera | Ennio Brizzolari | Key Grip |
| Directing | Ruggero Salvadori | Assistant Director |
| Sound | Alessandro Peticca | Sound Editor |
| Camera | Roberto Forges Davanzati | Underwater Camera |
| Camera | Carlo Tafani | Camera Operator |
| Art | Franco Vanorio | Art Direction |
| Costume & Make-Up | Mirella De Rossi | Hairstylist |
| Visual Effects | Giannetto De Rossi | Special Effects Supervisor |
| Camera | Roberto D'Ettorre Piazzoli | Underwater Director of Photography |
| Camera | Erich Heindl | Underwater Camera |
| Costume & Make-Up | Maurizio Trani | Makeup Artist |
| Art | Stephane Goulet | Property Master |
| Costume & Make-Up | Nicoletta Ercole | Costume Design |
| Editing | Roberto Silvi | Editor |
| Directing | Alessandro Vivarelli | Assistant Director |
| Art | Ronnie Lombard | Greensman |
| Camera | Gianni Caramanico | Still Photographer |
| Editing | Ada Grimaldi | Assistant Editor |
| Art | Stefano Paltrinieri | Art Direction |
| Camera | Roberto D'Ettorre Piazzoli | Director of Photography |
| Costume & Make-Up | Giannetto De Rossi | Makeup Designer |
| Lighting | Luigi Pasqualini | Gaffer |
| Directing | Ovidio G. Assonitis | Co-Director |
| Directing | Miller Drake | Co-Director |
